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Pharmacokinetics of 100 mg/day spironolactone and its metabolites
| Compound |
CmaxTooltip Peak concentrations (day 1) |
CmaxTooltip Peak concentrations (day 15) |
AUCTooltip Area-under-the-curve concentrations (day 15) |
t1/2Tooltip Elimination half-life
|
| Spironolactone |
72 ng/mL (173 nmol/L) |
80 ng/mL (192 nmol/L) |
231 ng•hour/mL (555 nmol•hour/L) |
1.4 hours
|
| Canrenone |
155 ng/mL (455 nmol/L) |
181 ng/mL (532 nmol/L) |
2,173 ng•hour/mL (6,382 nmol•hour/L) |
16.5 hours
|
| 7α-TMSTooltip 7α-Thiomethylspironolactone |
359 ng/mL (924 nmol/L) |
391 ng/mL (1,006 nmol/L) |
2,804 ng•hour/mL (7,216 nmol•hour/L) |
13.8 hours
|
| 6β-OH-7α-TMSTooltip 6β-Hydroxy-7α-thiomethylspironolactone |
101 ng/mL (250 nmol/L) |
125 ng/mL (309 nmol/L) |
1,727 ng•hour/mL (4,269 nmol•hour/L) |
15.0 hours
|
| Sources: [1]
|
- ^ Gardiner P, Schrode K, Quinlan D, Martin BK, Boreham DR, Rogers MS, Stubbs K, Smith M, Karim A (1989). "Spironolactone metabolism: steady-state serum levels of the sulfur-containing metabolites". J Clin Pharmacol. 29 (4): 342–7. doi:10.1002/j.1552-4604.1989.tb03339.x. PMID 2723123.
