Template:Infobox gene/testcases

Old versus new

{{GNF Protein box}}	{{GNF Protein box/sandbox}}
DRD1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OZ5 Identifiers Aliases DRD1, dopamine receptor D1, DADR, DRD1A External IDs OMIM: 126449; MGI: 99578; HomoloGene: 30992; GeneCards: DRD1; OMA:DRD1 - orthologs Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.2 Start 175,440,036 bp End 175,444,182 bp Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B1|13 28.4 cM Start 54,205,202 bp End 54,209,724 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen gonad prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 46 Top expressed in nucleus accumbens dorsal striatum olfactory tubercle globus pallidus superior frontal gyrus temporal lobe amygdala neural layer of retina urethra lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data Gene ontology Molecular function dopamine neurotransmitter receptor activity dopamine binding protein binding dopamine neurotransmitter receptor activity, coupled via Gs G protein-coupled receptor activity signal transducer activity G-protein alpha-subunit binding Cellular component membrane nucleus endoplasmic reticulum integral component of membrane plasma membrane endoplasmic reticulum membrane integral component of plasma membrane ciliary membrane endomembrane system non-motile cilium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane dendritic spine dendrite cell projection cilium Biological process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway muscle contraction protein import into nucleus positive regulation of potassium ion transport response to amphetamine learning feeding behavior long-term depression temperature homeostasis striatum development prepulse inhibition response to cocaine grooming behavior behavioral response to cocaine locomotory behavior dentate gyrus development transmission of nerve impulse memory positive regulation of synaptic transmission, glutamatergic synapse assembly habituation adult walking behavior peristalsis cellular response to catecholamine stimulus adenylate cyclase-activating dopamine receptor signaling pathway regulation of dopamine uptake involved in synaptic transmission associative learning astrocyte development G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of release of sequestered calcium ion into cytosol mating behavior behavioral fear response activation of adenylate cyclase activity dopamine receptor signaling pathway conditioned taste aversion cerebral cortex GABAergic interneuron migration glucose import visual learning sensitization positive regulation of cell migration operant conditioning vasodilation regulation of dopamine metabolic process dopamine metabolic process phospholipase C-activating dopamine receptor signaling pathway maternal behavior dopamine transport hippocampus development neuronal action potential long-term potentiation signal transduction synaptic transmission, dopaminergic positive regulation of gene expression cellular response to dopamine regulation of protein phosphorylation G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 1812 13488 Ensembl ENSG00000184845 ENSMUSG00000021478 UniProt P21728 Q61616 RefSeq (mRNA) NM_000794 NM_001291801 NM_010076 RefSeq (protein) NP_000785 NP_001278730 NP_034206 Location (UCSC) Chr 5: 175.44 – 175.44 Mb Chr 13: 54.21 – 54.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse	DRD1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OZ5 Identifiers Aliases DRD1 (HUGO), dopamine receptor D1, DADR, DRD1A External IDs OMIM: 126449   MGI: 99578   HomoloGene: 30992   GeneCards: DRD1   OMA: DRD1 - orthologs Gene location (Human) Chromosome: 5 (human) Band 5q35.2 Start 175,440,036 bp End 175,444,182 bp Gene location (Mouse) Chromosome: 13 (mouse) Band 13 B1|13 28.4 cM Start 54,205,202 bp End 54,209,724 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen gonad prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 46 Top expressed in nucleus accumbens dorsal striatum olfactory tubercle globus pallidus superior frontal gyrus temporal lobe amygdala neural layer of retina urethra lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data Gene ontology Molecular function dopamine neurotransmitter receptor activity dopamine binding protein binding  dopamine neurotransmitter receptor activity, coupled via Gs G protein-coupled receptor activity signal transducer activity G-protein alpha-subunit binding Cell component membrane nucleus  endoplasmic reticulum  integral component of membrane plasma membrane  endoplasmic reticulum membrane integral component of plasma membrane ciliary membrane endomembrane system  non-motile cilium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane dendritic spine  dendrite  cell projection cilium  Biological process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway muscle contraction  protein import into nucleus positive regulation of potassium ion transport response to amphetamine learning  feeding behavior long-term depression  temperature homeostasis striatum development prepulse inhibition  response to cocaine grooming behavior  behavioral response to cocaine locomotory behavior dentate gyrus development transmission of nerve impulse memory  positive regulation of synaptic transmission, glutamatergic synapse assembly  habituation  adult walking behavior peristalsis  cellular response to catecholamine stimulus adenylate cyclase-activating dopamine receptor signaling pathway regulation of dopamine uptake involved in synaptic transmission associative learning  astrocyte development G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of release of sequestered calcium ion into cytosol mating behavior behavioral fear response activation of adenylate cyclase activity dopamine receptor signaling pathway conditioned taste aversion  cerebral cortex GABAergic interneuron migration glucose import visual learning  sensitization positive regulation of cell migration operant conditioning  vasodilation  regulation of dopamine metabolic process dopamine metabolic process phospholipase C-activating dopamine receptor signaling pathway maternal behavior dopamine transport hippocampus development neuronal action potential long-term potentiation  signal transduction  synaptic transmission, dopaminergic positive regulation of gene expression cellular response to dopamine regulation of protein phosphorylation G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of synaptic vesicle exocytosis Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 1812 13488 Ensembl ENSG00000184845 ENSMUSG00000021478 UniProt P21728 Q61616 RefSeq (RNAm) NM_000794 NM_001291801 NM_010076 RefSeq (protein) NP_000785 NP_001278730 NP_034206 Location (UCSC) Chr 5: 175.44 – 175.44 Mb Chr 13: 54.21 – 54.21 Mb PubMed search Wikidata View/Edit Human gene View/Edit Mouse gene
INS Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SF1, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZNJ, 2AIY, 2C8Q, 2C8R, 2CEU, 2H67, 2HH4, 2HHO, 2HIU, 2JMN, 2JUM, 2JUU, 2JUV, 2JV1, 2JZQ, 2K91, 2K9R, 2KJJ, 2KJU, 2KQQ, 2KXK, 2L1Y, 2L1Z, 2LGB, 2M1D, 2M1E, 2M2M, 2M2N, 2M2O, 2M2P, 2OLY, 2OLZ, 2OM0, 2OM1, 2OMG, 2OMH, 2OMI, 2QIU, 2R34, 2R35, 2R36, 2RN5, 2VJZ, 2VK0, 2W44, 2WBY, 2WC0, 2WRU, 2WRV, 2WRW, 2WRX, 2WS0, 2WS1, 2WS4, 2WS6, 2WS7, 3AIY, 3BXQ, 3E7Y, 3E7Z, 3EXX, 3FQ9, 3I3Z, 3I40, 3ILG, 3INC, 3IR0, 3Q6E, 3ROV, 3TT8, 3U4N, 3UTQ, 3UTS, 3UTT, 3V19, 3V1G, 3W11, 3W12, 3W13, 3W7Y, 3W7Z, 3W80, 3ZI3, 3ZQR, 3ZS2, 3ZU1, 4AIY, 4AJX, 4AJZ, 4AK0, 4AKJ, 4EFX, 4EWW, 4EWX, 4EWZ, 4EX0, 4EX1, 4EXX, 4EY1, 4EY9, 4EYD, 4EYN, 4EYP, 4F0N, 4F0O, 4F1A, 4F1B, 4F1C, 4F1D, 4F1F, 4F1G, 4F4T, 4F4V, 4F51, 4F8F, 4FG3, 4FKA, 4GBC, 4GBI, 4GBK, 4GBL, 4GBN, 4IUZ, 5AIY, 2LWZ, 3JSD, 3KQ6, 3P2X, 3P33, 1JK8, 2MLI, 2MPG, 2MPI, 2MVC, 2MVD, 4CXL, 4CXN, 4CY7, 4NIB, 4OGA, 4P65, 4Q5Z, 4RXW, 4UNE, 4UNG, 4UNH, 4XC4, 4WDI, 4Z76, 4Z77, 4Z78, 2N2W, 5CO6, 5ENA, 4Y19, 5BQQ, 5BOQ, 2N2V, 5CNY, 5CO9, 5EN9, 4Y1A, 2N2X, 5BPO, 5CO2, 5BTS, 5HYJ, 5C0D,%%s1EFE, 1SJT, 1SJU, 2KQP,%%s1T0C,%%s2G54, 2G56, 3HYD, 2OMQ Identifiers Aliases INS, IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, insulin, PNDM4 External IDs OMIM: 176730; MGI: 96573; HomoloGene: 173; GeneCards: INS; OMA:INS - orthologs Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 2,159,779 bp End 2,161,221 bp Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F5|7 88.0 cM Start 142,232,393 bp End 142,297,118 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell body of pancreas right lobe of liver right adrenal gland left adrenal gland left adrenal cortex right adrenal cortex ectocervix Descending thoracic aorta left uterine tube Top expressed in islet of Langerhans pyloric antrum choroid plexus of fourth ventricle Epithelium of choroid plexus human fetus yolk sac retinal pigment epithelium embryo secondary oocyte primordial pancreas More reference expression data BioGPS More reference expression data Gene ontology Molecular function insulin receptor binding identical protein binding protease binding insulin-like growth factor receptor binding protein binding hormone activity Cellular component endoplasmic reticulum lumen transport vesicle Golgi membrane secretory granule lumen Golgi lumen endoplasmic reticulum-Golgi intermediate compartment membrane endosome lumen extracellular region extracellular space Biological process negative regulation of NAD(P)H oxidase activity positive regulation of DNA replication positive regulation of MAPK cascade positive regulation of brown fat cell differentiation positive regulation of cell differentiation MAPK cascade positive regulation of respiratory burst positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of protein oligomerization positive regulation of NF-kappaB transcription factor activity negative regulation of respiratory burst involved in inflammatory response cell-cell signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycolytic process positive regulation of nitric-oxide synthase activity positive regulation of protein autophosphorylation activation of protein kinase B activity wound healing positive regulation of mitotic nuclear division negative regulation of feeding behavior positive regulation of peptide hormone secretion negative regulation of protein catabolic process positive regulation of cell migration acute-phase response regulation of protein secretion positive regulation of glycogen biosynthetic process positive regulation of protein kinase B signaling G protein-coupled receptor signaling pathway regulation of cellular amino acid metabolic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway endoplasmic reticulum to Golgi vesicle-mediated transport negative regulation of lipid catabolic process positive regulation of cell growth negative regulation of glycogen catabolic process positive regulation of insulin receptor signaling pathway glucose metabolic process negative regulation of acute inflammatory response negative regulation of protein secretion positive regulation of peptidyl-tyrosine phosphorylation glucose homeostasis positive regulation of cell population proliferation fatty acid homeostasis positive regulation of protein metabolic process regulation of transmembrane transporter activity negative regulation of gluconeogenesis negative regulation of fatty acid metabolic process regulation of protein localization regulation of transcription, DNA-templated positive regulation of lipid biosynthetic process carbohydrate metabolic process negative regulation of proteolysis alpha-beta T cell activation positive regulation of protein localization to nucleus positive regulation of glucose import insulin receptor signaling pathway positive regulation of gene expression regulation of signaling receptor activity positive regulation of nitric oxide mediated signal transduction regulation of synaptic plasticity cognition positive regulation of long-term synaptic potentiation positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance response to L-arginine signal transduction Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 3630 16334 Ensembl ENSG00000254647 ENSMUSG00000000215 UniProt P01308 P01326 RefSeq (mRNA) NM_000207 NM_001185097 NM_001185098 NM_001291897 NM_001185083 NM_001185084 NM_008387 RefSeq (protein) NP_000198 NP_001172026 NP_001172027 NP_001278826 NP_000198.1 NP_001172026.1 NP_001172027.1 NP_001278826.1 NP_000198 NP_000198 NP_000198 NP_000198 NP_001172012 NP_001172013 NP_032413 Location (UCSC) Chr 11: 2.16 – 2.16 Mb Chr 7: 142.23 – 142.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse	INS Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SF1, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZNJ, 2AIY, 2C8Q, 2C8R, 2CEU, 2H67, 2HH4, 2HHO, 2HIU, 2JMN, 2JUM, 2JUU, 2JUV, 2JV1, 2JZQ, 2K91, 2K9R, 2KJJ, 2KJU, 2KQQ, 2KXK, 2L1Y, 2L1Z, 2LGB, 2M1D, 2M1E, 2M2M, 2M2N, 2M2O, 2M2P, 2OLY, 2OLZ, 2OM0, 2OM1, 2OMG, 2OMH, 2OMI, 2QIU, 2R34, 2R35, 2R36, 2RN5, 2VJZ, 2VK0, 2W44, 2WBY, 2WC0, 2WRU, 2WRV, 2WRW, 2WRX, 2WS0, 2WS1, 2WS4, 2WS6, 2WS7, 3AIY, 3BXQ, 3E7Y, 3E7Z, 3EXX, 3FQ9, 3I3Z, 3I40, 3ILG, 3INC, 3IR0, 3Q6E, 3ROV, 3TT8, 3U4N, 3UTQ, 3UTS, 3UTT, 3V19, 3V1G, 3W11, 3W12, 3W13, 3W7Y, 3W7Z, 3W80, 3ZI3, 3ZQR, 3ZS2, 3ZU1, 4AIY, 4AJX, 4AJZ, 4AK0, 4AKJ, 4EFX, 4EWW, 4EWX, 4EWZ, 4EX0, 4EX1, 4EXX, 4EY1, 4EY9, 4EYD, 4EYN, 4EYP, 4F0N, 4F0O, 4F1A, 4F1B, 4F1C, 4F1D, 4F1F, 4F1G, 4F4T, 4F4V, 4F51, 4F8F, 4FG3, 4FKA, 4GBC, 4GBI, 4GBK, 4GBL, 4GBN, 4IUZ, 5AIY, 2LWZ, 3JSD, 3KQ6, 3P2X, 3P33, 1JK8, 2MLI, 2MPG, 2MPI, 2MVC, 2MVD, 4CXL, 4CXN, 4CY7, 4NIB, 4OGA, 4P65, 4Q5Z, 4RXW, 4UNE, 4UNG, 4UNH, 4XC4, 4WDI, 4Z76, 4Z77, 4Z78, 2N2W, 5CO6, 5ENA, 4Y19, 5BQQ, 5BOQ, 2N2V, 5CNY, 5CO9, 5EN9, 4Y1A, 2N2X, 5BPO, 5CO2, 5BTS, 5HYJ, 5C0D,%%s1EFE, 1SJT, 1SJU, 2KQP,%%s1T0C,%%s2G54, 2G56, 3HYD, 2OMQ Identifiers Aliases INS (HUGO), IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, insulin, PNDM4 External IDs OMIM: 176730   MGI: 96573   HomoloGene: 173   GeneCards: INS   OMA: INS - orthologs Gene location (Human) Chromosome: 11 (human) Band 11p15.5 Start 2,159,779 bp End 2,161,221 bp Gene location (Mouse) Chromosome: 7 (mouse) Band 7 F5|7 88.0 cM Start 142,232,393 bp End 142,297,118 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell body of pancreas right lobe of liver right adrenal gland left adrenal gland left adrenal cortex right adrenal cortex ectocervix Descending thoracic aorta left uterine tube Top expressed in islet of Langerhans pyloric antrum choroid plexus of fourth ventricle Epithelium of choroid plexus human fetus yolk sac retinal pigment epithelium embryo secondary oocyte primordial pancreas More reference expression data BioGPS More reference expression data Gene ontology Molecular function insulin receptor binding identical protein binding protease binding insulin-like growth factor receptor binding protein binding  hormone activity Cell component endoplasmic reticulum lumen transport vesicle Golgi membrane secretory granule lumen Golgi lumen endoplasmic reticulum-Golgi intermediate compartment membrane endosome lumen extracellular region  extracellular space  Biological process negative regulation of NAD(P)H oxidase activity positive regulation of DNA replication positive regulation of MAPK cascade positive regulation of brown fat cell differentiation positive regulation of cell differentiation MAPK cascade positive regulation of respiratory burst positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of protein oligomerization positive regulation of NF-kappaB transcription factor activity negative regulation of respiratory burst involved in inflammatory response cell-cell signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycolytic process positive regulation of nitric-oxide synthase activity positive regulation of protein autophosphorylation activation of protein kinase B activity wound healing  positive regulation of mitotic nuclear division negative regulation of feeding behavior positive regulation of peptide hormone secretion negative regulation of protein catabolic process positive regulation of cell migration acute-phase response regulation of protein secretion positive regulation of glycogen biosynthetic process positive regulation of protein kinase B signaling G protein-coupled receptor signaling pathway regulation of cellular amino acid metabolic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway endoplasmic reticulum to Golgi vesicle-mediated transport negative regulation of lipid catabolic process positive regulation of cell growth negative regulation of glycogen catabolic process positive regulation of insulin receptor signaling pathway glucose metabolic process negative regulation of acute inflammatory response negative regulation of protein secretion positive regulation of peptidyl-tyrosine phosphorylation glucose homeostasis positive regulation of cell population proliferation fatty acid homeostasis positive regulation of protein metabolic process regulation of transmembrane transporter activity negative regulation of gluconeogenesis negative regulation of fatty acid metabolic process regulation of protein localization regulation of transcription, DNA-templated positive regulation of lipid biosynthetic process carbohydrate metabolic process  negative regulation of proteolysis alpha-beta T cell activation positive regulation of protein localization to nucleus positive regulation of glucose import insulin receptor signaling pathway positive regulation of gene expression regulation of signaling receptor activity positive regulation of nitric oxide mediated signal transduction regulation of synaptic plasticity cognition  positive regulation of long-term synaptic potentiation positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance response to L-arginine signal transduction  Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 3630 16334 Ensembl ENSG00000254647 ENSMUSG00000000215 UniProt P01308 P01326 RefSeq (RNAm) NM_000207 NM_001185097 NM_001185098 NM_001291897 NM_001185083 NM_001185084 NM_008387 RefSeq (protein) NP_000198 NP_001172026 NP_001172027 NP_001278826 NP_000198.1 NP_001172026.1 NP_001172027.1 NP_001278826.1 NP_000198 NP_000198 NP_000198 NP_000198 NP_001172012 NP_001172013 NP_032413 Location (UCSC) Chr 11: 2.16 – 2.16 Mb Chr 7: 142.23 – 142.3 Mb PubMed search Wikidata View/Edit Human gene View/Edit Mouse gene