Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer

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Comparison of early clinical experience with antiestrogens for advanced breast cancer
Antiestrogen	Dosage	Year(s)	Response rate	Adverse effects
Ethamoxytriphetol	500–4,500 mg/day	1960	25%	Acute psychotic episodes
Clomifene	100–300 mg/day	1964–1974	34%	Risks of cataracts
Nafoxidine	180–240 mg/day	1976	31%	Cataracts, ichthyosis, photophobia
Tamoxifen	20–40 mg/day	1971–1973	31%	Transient thrombocytopenia^a
Footnotes: ^a = "The particular advantage of this drug is the low incidence of troublesome side effects (25)." "Side effects were usually trivial (26)." Sources: ^[1]^[2]

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