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Chemical compound
Temocapril AHFS /Drugs.com International Drug Names ATC code
2-[(2S )-6-[[(2S )-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) Formula C 23 H 28 N 2 O 5 S 2 Molar mass 476.61 g·mol−1 3D model (JSmol )
CCOC(=O)[C@H](CCc1ccccc1)NC2CS[C@@H](CN(C2=O)CC(=O)O)c3cccs3
InChI=1S/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18?,20-/m0/s1
Key:FIQOFIRCTOWDOW-DXCJPMOASA-N
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Temocapril (also known as temocaprilum [Latin]; brand name Acecol) is an ACE inhibitor . It was not approved for use in the US .
It is administered as inactive prodrug , then converted to its active metabolite, temocaprilat.[ 1]
It was patented in 1984 and approved for medical use in 1994.[ 2]
^ Yasunari, K., Maeda, K., Nakamura, M., Watanabe, T., Yoshikawa, J., & Asada, A. (2004). Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovascular drug reviews, 22(3), 189–198. https://doi.org/10.1111/j.1527-3466.2004.tb00140.x
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery . John Wiley & Sons. p. 469. ISBN 9783527607495 .
ACE inhibitors ("-pril")
Sulfhydryl-containing : Captopril
Rentiapril
Zofenopril (+nebivolol )
Dicarboxylate-containing : Enalapril # (+lercanidipine , +nitrendipine )
Benazepril (+amlodipine , +pimobendan )
Cilazapril
Delapril (+manidipine )
Imidapril
Lisinopril (+amlodipine , +HCT )
Moexipril
Perindopril (+amlodipine , +bisoprolol , +indapamide , +amlodipine and indapamide , +bisoprolol and amlodipine , +bisoprolol, amlodipine, and indapamide )
Quinapril (+HCT )
Ramipril (+amlodipine , +amlodipine and HCT , +bisoprolol , +felodipine )
Spirapril
Temocapril
Trandolapril (+verapamil )
Phosphonate-containing : Ceronapril
Fosinopril (+HCT )
Other/ungrouped: Alacepril
AIIRAs ("-sartan")
Azilsartan
Candesartan (+amlodipine , +amlodipine and HCT )
Eprosartan
Fimasartan
Irbesartan (+amlodipine , +amlodipine and HCT , +HCT )
Losartan (+amlodipine , +HCT )
Olmesartan (+amlodipine , +amlodipine and HCT , +HCT )
Tasosartan §
Telmisartan (+amlodipine , +amlodipine and HCT , +HCT )
Valsartan (+aliskiren , +amlodipine , +amlodipine and HCT , +HCT , +lercanidipine , +nebivolol , +sacubitril )
Renin inhibitors ("-kiren")Dual ACE /NEP inhibitors Neprilysin inhibitorsOther
ATR Tooltip Angiotensin receptor Combinations: