Talk:Zonulin

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Medicine: Gastroenterology / Genetics Low‑importance

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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier Lael M. Yonker, … , David R. Walt, Alessio Fasano Published May 25, 2021 Citation Information: J Clin Invest. 2021. https://doi.org/10.1172/JCI149633.

Objective references

Article appears to have a sensational anti-gluten bias. More reputable sources are needed. — Preceding unsigned comment added by Melisaabailey (talk • contribs) 20:34, 14 July 2016 (UTC)[reply]

OK I've added a further 3 citations to peer reviewed research / reviews on this matter (end of 2nd paragraph). That's 4 in total now. There is no shortage of research from what I'm seeing - it seems perfectly firmly established that gliadin activates zonulin and impacts intestinal permeability (tight junctions). Zarkme (talk) 05:46, 1 August 2016 (UTC)[reply]

I believe the POV issue is addressed. POV tag removed. Please discuss if you have further concerns. Thanks Zarkme (talk) 04:40, 2 August 2016 (UTC)[reply]

Also implicated in rheumatoid arthritis

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis - Nature article:

"Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice and humans and can be used to predict transition from autoimmunity to inflammatory arthritis. Increased serum zonulin levels are accompanied by a leaky intestinal barrier, dysbiosis and inflammation. Restoration of the intestinal barrier in the pre-phase of arthritis using butyrate or a cannabinoid type 1 receptor agonist inhibits the development of arthritis."

Facts707 (talk) 11:06, 21 March 2022 (UTC)[reply]