Talk:X-linked agammaglobulinemia

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note

Hello, I think the picture is partially wrong. When the father is affected (by an x-linked trait), or when the mother is a carrier, their daughters will be carriers, not affected.

I checked the picture, and from what I can tell it is correct, it shows the daughters being possible carriers if the father is affected or if the mother is a carrier, but shows how whether or not the son is afflicted with the disease is dependent on the genes passed to him by his mother. (D.c.camero (talk) 01:42, 14 September 2008 (UTC))[reply]

Autoimmunity & XLA

I do not think the statement "Unlike in other primary immunodeficiencies XLA patients are at no greater risk for developing autoimmune illnesses", is entirely correct.

There has been anecdotal evidence among immunologists that autoimmune/autoinflammatory conditions among persons with XLA is under diagnosed and under reported. As a matter of fact the United States Immune Deficiency Network (USIDNET) XLA Subcommitte headed a project examining this very issue. A comparison of data between the patient consented USIDNET clinical registry and a survey of persons with XLA indicates that persons with XLA are indeed more likely to report either a diagnosed autoimmune condition or have combinations of symptoms that would indicate an AI than is documented in current medical literature.

Link to abstract as published in the Journal of Allergy and Clinical Immunology: ^[1]

Indications of Autoimmunity and Auto-Inflammation in X-Linked Agammaglobulinemia Vivian P. Hernandez-Trujillo, MD, FAAAAI,Christopher Scalchunes, MPA,Charlotte Cunningham-Rundles, MD, PhD, FAAAAI,Hans D. Ochs, MD, Kathleen E. Sullivan, MD, PhD, FAAAAI DOI: http://dx.doi.org/10.1016/j.jaci.2012.12.917

Please consider changing this section of the article.

Thank you for your consideration. 50.198.128.97 (talk) 16:57, 3 December 2014 (UTC)[reply]

References

^ http://www.jacionline.org/article/S0091-6749%2812%2902918-1/abstract

Why is an X-linked disorder much more common in males?

Why is an X-linked disorder much more common in males? - I can guess, but in the introduction it would be better not to expect the reader to guess. This has been written for the general reader, right? (an individual with two X chromosomes would need to have the mutation in both to suffer, whereas a male with a typical X plus Y arrangement would have the disorder if there X chromosome was affected - but as a general reader I'm just guessing here!) 92.237.13.56 (talk) 10:10, 1 March 2016 (UTC)[reply]

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Other considerations - XLA susceptibility to enteroviruses

I am concerned that the information regarding XLA patients susceptibility to enteroviruses is incomplete but as I'm not particularly well-versed in this field I did not want to modify it. Chapter 13 of 'Neuropathology' (Second edition, by Ellison, Love, Chimelli, Harding, Lowe, Vinters) discusses chronic and acute viral infections of the CNS. In this chapter it discusses how patients with XLA rarely develop chronic encephalopathy or myelopathy after enteroviral exposure. I think a citation, at the very least, is needed to support the claim that XLA patients are specifically susceptible to enteroviruses, and clarification on how they can develop chronic inflammatory conditions without mature B cells. Biochembot17 (talk) 15:00, 1 March 2023 (UTC)[reply]

[1] ttp://www.jacionline.org/article/S0091-6749%2812%2902918-1/abstract

[1]