Talk:Uniparental disomy

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In

In the third paragraph, it currently states: "However, if the UPD causing event happens during meiosis I, the genotype may include identical copies of the uniparental chromosome (isodisomy), leading to the manifestation of rare recessive disorders." I'm pretty sure this is only likely to occur if the UPD causing event occurs in meiosis II, when the sister chromatids separate. I will change it. If I am wrong, comment here and then change it back.

Dwinetsk 09:12, 13 November 2007 (UTC)[reply]

When the child receives the (two) homologous chromosomes (inherited from both grandparents) from one parent, this is called an heterodisomic UPD. I'm confused. The way this is worded, it sounds like that would mean that the child would inherit all of, say, his father's chromosomes, and none of his mother's. Would that make the child, in effect, a clone of his father? Nik42 (talk) 01:32, 30 April 2008 (UTC)[reply]

Never mind. I figured it out. It's only one pair of chromosomes involved, not all 23 ... but that would mean that the child would be more closely related to one parent than the other, yes? Nik42 (talk) 01:34, 30 April 2008 (UTC)[reply]

Clarity of the lede to the layperson

Currently the lede says in its entirety:

Uniparental disomy (UPD) occurs when a person receives two copies of a chromosome, or of part of a chromosome, from one parent and no copies from the other parent.[1]. UPD can be the result of isodisomy (meiosis II error) or heterodisomy (meiosis I error)[2] .

The first sentence is great for the lay reader, but the second is not. "Isodisomy" and "heterodisomy" need to be defined in laypersons' terms, but the parenthetical comments don't do the trick. Clarification, please. Thanks. Duoduoduo (talk) 14:37, 11 October 2012 (UTC)[reply]

All chromosomes?

I vote for deleting this section. it is not clear what is meant by "all chromosomes", the reference link is broken and what is recoverable from the wayback machine is a figure illustrating the distinction between heterodisomy and isodisomy. — Preceding unsigned comment added by 81.191.194.157 (talk) 15:49, 2 October 2020 (UTC)[reply]

Should segmental UDP be contain in the definition of UPD?

I've read some articals about UPD, most of which said both copies of a whole chromosome pair have originated from one parent is UPD, like https://doi.org/10.1002/pd.5837, https://www.sciencedirect.com/topics/neuroscience/uniparental-disomy. But some didn't, like PMC8800777 said "Uniparental disomy (UPD) refers to a chromosome defect that an individual's homologous chromosome or segments are inherited from one parent." It seems that the citation used in this entry cannot proof UDP is "or of part of a chromosome". Which one is right? Heihaheihaha (talk) 14:22, 28 January 2024 (UTC)[reply]