Talk:Thymol

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When was thymol first isolated?

In the History section it is claimed that Neumann isolated thymol in 1719. In the thyme article it is indicated that this was done in 1725. In the Caspar Neumann article it is said that he died before both these dates (in 1715). moliate (talk) 15:05, 4 May 2010 (UTC)[reply]

phenol/alcohol stub

Shouldn't this page be categorized as a Phenol stub rather than an alcohol stub? Bfesser 19:33, 30 January 2007 (UTC)[reply]

We don't have a category specifically for phenol stubs. But since the article isn't really a stub anyway, I've removed the tag. --Ed (Edgar181) 19:46, 30 January 2007 (UTC)[reply]

Preservative in anaesthetic

I've read somewhere that thymol is used as a preservative in one of the gaseous anaesthetics. 89.240.7.222 19:39, 26 May 2007 (UTC)[reply]

Yes - a small amount of thymol (0.01%) is added to halothane to make it more light-stable. link Doctorbass00 (talk) 15:42, 19 February 2018 (UTC)[reply]

Aroma

What does thymol actually smell of? Nonagonal Spider 00:44, 15 July 2007 (UTC)[reply]

It smells like thyme and oragano, which is not so strange since both contain thymol. — Preceding unsigned comment added by 81.71.184.132 (talk) 12:15, 15 February 2012 (UTC)[reply]

WikiProject Food and drink Tagging

This article talk page was automatically added with {{WikiProject Food and drink}} banner as it falls under Category:Food or one of its subcategories. If you find this addition an error, Kindly undo the changes and update the inappropriate categories if needed. The bot was instructed to tagg these articles upon consenus from WikiProject Food and drink. You can find the related request for tagging here . Maximum and careful attention was done to avoid any wrongly tagging any categories , but mistakes may happen... If you have concerns , please inform on the project talk page -- TinucherianBot (talk) 01:13, 4 July 2008 (UTC)[reply]

Relevence of propofol comparison

Given that the reference to GABA agonism states that thymol must have a unique binding site, I don't see how the MoA of thymol should be described as 'similar to' that of propofol, given that it's no more similat than that of benzos or any other GABA-A agonist. I propose that unless someone can find a paper specifically citing a similar MoA to propofol, this statement should be removed. In particular I think that the statement that propofol has abuse potential is completely irrelevant to this article. Unless someone with knowledge confirms the relevance of the propofol references I'll remove them in the next week or so. —Preceding unsigned comment added by Taslam2 (talk • contribs) 06:44, 17 August 2009 (UTC)[reply]

Also the statement that thymol may have 'abuse potential' appears to be an assumption. Just because it displays GABA agonism does not automatically make it a candidate for recreational reward seeking. Consider chamomile, for instance. I've seen no evidence for this so I'm removing it until I see a journal article documenting abuse. Speculation doesn't belong in an encylopaedia. - Taslam2 —Preceding unsigned comment added by 78.16.106.195 (talk) 01:47, 19 August 2009 (UTC)[reply]

This issue is now important to the edits, and my suggested deletion of the biological activity section which still contains the claim that Taslam2 specified above. Tlow03 (talk) 03:22, 8 October 2010 (UTC)[reply]

The antibacterial potent of the chemical.....

http://scholar.google.com.hk/scholar?as_q=thymol+antibacterial&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=title&as_sauthors=&as_publication=&as_ylo=&as_yhi=&as_sdt=1.&as_sdtp=on&as_sdts=5&hl=en

--222.64.209.200 (talk) 04:24, 29 March 2010 (UTC)[reply]

http://scholar.google.com.hk/scholar?hl=en&q=allintitle%3A+thymol+anti+bacterial&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0

--222.64.209.200 (talk) 04:26, 29 March 2010 (UTC)[reply]

Info about the chemical as a natural preservative.....

http://scholar.google.com.hk/scholar?hl=en&q=allintitle%3A+thymol+preservative&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0

--222.64.209.200 (talk) 04:33, 29 March 2010 (UTC)[reply]

Look at the mess the site has created....

Eespecially for the section of Compendial status --222.64.31.231 (talk) 03:20, 21 April 2010 (UTC)[reply]

If my memory serves me well, the edition signs that I put were dated --222.64.31.231 (talk) 03:16, 21 April 2010 (UTC)[reply]

IUPAC name?

So, the article lists it as 2-isopropyl-5-methylphenol. However, isn't the purpose of the system to give each part the lowest numbers? This could also be called a toluene derivative. In that case, the methyl group would become the first carbon, and the name would be 3-hydroxy-4-isopropyltoluene. Can anyone give me an explanation as to why we have the current name, or did someone just name it incorrectly?71.30.90.131 (talk) 03:26, 21 April 2010 (UTC)[reply]

Biological Activity Inaccuracies

The evidence reported here suggests that thymol does not share sites of action with many of the most widely investigated allosteric modulators of GABAA activity, these being benzodiazepines, β-carbolines, barbiturates, propofol, loreclezole and steroids. It is still contentious as to whether the barbiturates and propofol act as agonists and positive modulators via the same or distinct sites.

From the cited article, the claims made in the biological activity section are unsupported.

I suggest that this section be deleted until the claim can be supported. Tlow03 (talk) 03:18, 8 October 2010 (UTC)[reply]

Additional Biological Activity Edits

I've done substantial research on the biological properties of thymol, particularly with respect to antimicrobial activity, and have some additional information about toxicology and environmental breakdown that I would like to add. Several papers from scientific journals serve as background for these edits and will be cited. O.khayyam (talk) 20:32, 2 December 2010 (UTC)[reply]

Effects of Thyme oil on fungal infection of nail and skin in feet and hands

On treatment of fungal toenail infection: I have used a product as sold on Amazon.co.uk Thyme oil manufactured by Essential Oils Direct and found it stains the fungal infected nail and also skin dark brown, showing it up so I could see clearly to cut it out. I have got very good results over 1 and a half years use - I've also used Tea tree oil alternating alongside the Thyme oil - which may have helped, but the Thyme oil stains it dark brown where previously invisible in the surrounding skin, as dark dots. I do not know if it kills it though, however I would say it is over 90% beaten now. More appeared, it is not a simple thing to tackle at all. Products I used for 3 years before I tried this from chemists such as the usual file and paint on nail laquer products and tablets did nothing at all, seemed to be a fungibact instead of a fungicide, just stopping it from getting worser. Also, I had cracks around my heels - the doctors thought I should use moisturisers for dry skin. The Thyme oil stained heels and dark brown/black horseshoe shaped marks appeared in the skin - over a year I repeatedly filed this off, and now I have normal heel skin and no cracks. The Thyme oil also revealed dark brown splinters in the tips of my finger nails, and I think this was minor fungal infection, I scraped and cut it out and now there is no splinters appearing if the Thyme oil is applied. I also mixed Thyme oil with Listerine Teeth and Gums (Green) Mouthwash and sprayed onto the area as well. The alcohol content may have helped the oil dissolve and enable it to penetrate better. If the Thyme oil is applied now no dark stain appears on the heel. I just wanted to share this knowledge of my experimenting and use/testing in the talk. — Preceding unsigned comment added by 77.100.54.203 (talk) 01:59, 18 February 2015 (UTC)[reply]

Derivatives

Removed from the article for evaluation, better sources, and discussion. --Zefr (talk) 20:03, 1 January 2018 (UTC)[reply]

biclotymol.
Thymol can be brominated to bromthymol (CAS number 15062-34-7), which is a recognized anthelmintic drug.
929F, the N,N-diethylaminoethoxy ether of thymol,^[1] was an antihistamine that was studied, predating Benadryl.
Tymazoline, a vasoconstrictor. Nasal decongestant.

A thymol-derived analog of propranolol has the CAS number 5790-40-9.

Moxisylyte, also known as thymoxamine, is also made from thymol.
Iproxamine is another example.

References

^ Cheney, L. C.; Smith, Richard R.; Binkley, S. B. (1949). "Alkylaminoalkyl Ethers of the Benzylphenols". Journal of the American Chemical Society. 71 (1): 60–64. doi:10.1021/ja01169a017. ISSN 0002-7863.

pH indicator

In addition to thymolphtalein the derivative 6-bromothymol is a building block of the more common indicator bromothymol blue.150.227.15.253 (talk) 18:21, 22 March 2019 (UTC)[reply]

[CheneySmith1949-1] Cheney, L. C.; Smith, Richard R.; Binkley, S. B. (1949). "Alkylaminoalkyl Ethers of the Benzylphenols". Journal of the American Chemical Society. 71 (1): 60–64. doi:10.1021/ja01169a017. ISSN 0002-7863.

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