Talk:Thrombolysis

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current definition a bit too limited

Thrombolysis isn't just pharma, it can also be done though devices --e.g. Those that use HIFU. --216.9.250.104 (talk) 23:21, 29 November 2007 (UTC)[reply]

Merger proposal

I suggest merging Thrombolytic drug into Thrombolysis. There's an awful lot of overlap between the two articles at present. Both are quite short and both have been around since 2004. Comments? Qwfp (talk) 16:08, 22 April 2009 (UTC)[reply]

Both could be merged into a subheading under Fibrinolysis, a full entry that provides an extensive set of references. 68.173.53.167 (talk) 20:56, 13 January 2010 (UTC)[reply]

Both of these articles really belong under Fibrinolysis as the drugs interact with this system. —Preceding unsigned comment added by 99.149.199.86 (talk) 01:22, 26 January 2011 (UTC)[reply]

I'm not in favor, these seems distinct enough topics that we should leave them separate, even if they are currently similar. Ultrasound thrombolysis and other invasive non-drug treatments are on the horizon. Pro crast in a tor (talk) 19:28, 12 February 2011 (UTC)[reply]

Kids

doi:10.1111/j.1365-2141.2009.07914.x review on dosing and indications for thrombolysis in children. JFW | T@lk 21:05, 22 December 2009 (UTC)[reply]

unsourced

the following is unsourced; there is also no "principles" section in MEDMOS, and I am not sure what the goal of this content is

Principles

Formation of blood clots lies at the basis of a number of serious diseases (see below). By breaking down the clot, the disease process can be arrested, or the complications reduced. While other anticoagulants (such as heparin) prevent the "growth" of a clot, thrombolytic agents actively reduce the size of the clot.

Most thrombolytic agents work by activating the enzyme plasminogen, which clears the cross-linked fibrin mesh (the backbone of a clot). This makes the clot soluble and subject to further proteolysis by other enzymes, and restores blood flow over occluded blood vessels.

Principles of preventing blood clots from forming are handled by clinicians who assess the risk and if the risk of developing blood clots, the use of thrombolytic agents may be prevented. Oftentimes, thombolytic interventions are used with thrombosis prophylaxis.

-- Jytdog (talk) 01:04, 24 December 2016 (UTC)[reply]

Merge with contraindications

I think thrombolytic drug and contraindications to thrombolysis should both be merged here. JFW | T@lk 00:28, 29 December 2016 (UTC)[reply]

Merge agree these topics overlap extensively and that Thrombolysis is the right target. — soupvector (talk) 05:41, 31 December 2016 (UTC)[reply]
Done Mikael Häggström (talk) 09:09, 7 April 2017 (UTC)[reply]

Proposed merge with Thrombolytic drug

Already largely duplicated on target page where it would be better presented Iztwoz (talk) 08:24, 29 December 2016 (UTC)[reply]

Hm. We have a mess on our hands with the articles mentioned in the section above. The broadest article I have found is Reperfusion therapy which appropriately includes both drugs and devices, but unfortunately is solely focused on MI and strangely silent about ischemic stroke. I kind of think everything (including Embolectomy and should be merged to Reperfusion therapy first, and then if we need to splits from there, we can do that. I would be willing to do that mega-merge. Jytdog (talk) 08:35, 29 December 2016 (UTC)[reply]
weak support for merge as proposed by Iztwoz--Ozzie10aaaa (talk) 18:30, 30 December 2016 (UTC)[reply]

Just to note that I proposed merge, prompted by Merge needed posted by JFW. However Reperfusion therapy is new to me and perhaps Jytdog's proposal is a better alternative ? --Iztwoz (talk) 18:43, 30 December 2016 (UTC)[reply]

in that case, would support(go along w/ Jyt proposal)--Ozzie10aaaa (talk) 20:44, 30 December 2016 (UTC)[reply]

Reperfusion therapy is a very general topic, with multiple specific modalities each of which is complex and heavily documented in MEDRS - among the most active areas of biomedical publication in the past 20 years (with 4960 review articles in just the past 10 years!). I would suggest retaining Thrombolysis or Thrombolytic drug (i.e. merge them as suggested) and allow it to expand, with summary coverage of thrombolysis as a specific method for achieving reperfusion. That is, unless you also think we should also merge the following into Reperfusion therapy: (i) Angioplasty, (ii) Percutaneous coronary intervention, (iii) Coronary artery bypass surgery, (iv) Pulmonary embolectomy perhaps, ...? — soupvector (talk) 04:27, 31 December 2016 (UTC)[reply]

hmm. was thinking of consolidating them all as they are poorly knit together now but you are right that would be monumental. I would be happy with the merge of thombolytic drugs here, and making this an intervention article. Jytdog (talk) 05:30, 31 December 2016 (UTC)[reply]

Merge reasonable here. Doc James (talk · contribs · email) 06:38, 31 December 2016 (UTC)[reply]