Talk:Tetrahydrocannabinolic acid

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Poor prodrug "In vivo’ Misses the Point

As the earlier statement commented on how, upon heating, and directly referred to "by smoking" or by vaporizing, it is—if not plain incorrect-misleading to then call THCA a poor pro-drug in vivo; someone without a decent understanding of pharmacology is going to be thoroughly confused by this. 108.41.203.14 (talk) 03:12, 30 October 2022 (UTC)[reply]

The study cited for it being a poor prodrug would refer to consuming it orally (such as by mouth like an edible or capsule pill) as opposed to inhalation by smoking or vaporizing. If you eat THCA only a very tiny bit is converted to THC making THCA a poor prodrug to THC. Heating it externally (smoking, vaping, heating with an oven) to convert THCA into THC wouldn't be considered a prodrug. Prodrugs would be a drug metabolized by enzymes in the body into another drug. Gettinglit (talk) 01:34, 16 December 2022 (UTC)[reply]

still confused...so thca good or bad? And does Marijuana grow with this inside it naturally or is it genetically altered? Asking for a friend! 2601:541:C102:DBD0:3D9C:355E:E4CA:1DE (talk) 19:08, 8 December 2023 (UTC)[reply]

THCA is the primary cannabinoid that psychoactive Cannabis strains produce. When you smoke or vape Cannabis flower the THCA loses its carboxy group from the heat and forms THC which gets a person high. Gettinglit (talk) 00:23, 9 December 2023 (UTC)[reply]