Talk:Strontium ranelate

Comparison?

How can I compare Protelos with other anti-osteoporotic drugs, like Fosamax and Actonel?

References

This article makes direct claims that should be supported by references. JFW | T@lk 07:42, 8 July 2007 (UTC)

Ranelic Acid

The foolowing material was removed from ranelic acid because it refers to strontium ranelate. But most of this material seems to already be here. RJFJR (talk) 02:24, 16 February 2008 (UTC)

An experimental drug made by combining strontium with ranelic acid has aided in bone growth, boosted bone density and lessened fractures. (El-Hajj, 2004) Women receiving the drug showed a 6.8% increase in bone density. Women receiving a placebo had a 1.3% decrease. (Meunier, et. al, 2004).

Oral Strontium ranelate (Protelosr, Protosr - Servier) is the first in a new class of drugs called a Dual Action Bone Agents (DABA's), and has proven efficacy in the prevention of vertebral and non-vertebral fractures (including hip fracture). Strontium Ranelate works by stimulating the proliferation of osteoblast (bone building) cells (there is some debate about this), and inhibiting the proliferation of osteoclast (bone absorbing) cells. This means that strontium Ranelate increases Bone mineral density (BMD) by forming new bone, rather than just preserving existing bone. In comparison to bisphosphonates which only act on one aspect of bone remodeling, strontium ranelate also preserves bone turnover, allowing the microarchitecture of the bone to be continuously repaired as it would in healthy bone. Strontium ranelate is taken as a 2g oral suspension daily, and is licenced for the treatment of osteoporosis to prevent vertebral and hip fracture (this may differ by country and is not approved in the USA). Strontium ranelate has show significant efficacy at reducing both vertebral, and non-vertebral fractures in patients over the age of 80, who are the most at risk where osteoporosis is concerned. Strontium ranelate has side effect benefits over the bisphosphonates, as it does not cause any form of upper GI side effect, which is the most common cause for medication withdrawal in osteoporosis.

Mode of action

This section should confirm or deny that only the strontium ions have the osteogenic effect. How soluble is it in water, plasma etc What % disassociated in the body ? What effect does the ranelate group have ? What are the advantages of the ranelate over other soluble strontium salts/compounds ? Rod57 (talk) 15:01, 3 September 2009 (UTC)

Found "Strontium ranelate is slightly soluble in purified water (3.7mg/mL at saturation point) and practically insoluble in organic solvents (eg, methanol)." in http://www.medsafe.govt.nz/Profs/datasheet/p/Protossusp.htm which may be the source of the databox values too. Rod57 (talk) 15:10, 3 September 2009 (UTC)

This section is a little bit vague, eg "stimulates calcium receptors?". Perhaps more specificity would be helpful here. --58.169.244.101 (talk) 12:30, 3 August 2014 (UTC)

Indication

Whoever wrote this part of the article on Strontium Ranelate has made a factual error in stating that this medicine is not available on the NHS in the United Kingdom, it has been available since 2004. The person had written:

Strontium ranelate is registered in more than 70 countries for the treatment of post-menopausal osteoporosis to reduce the risk of vertebral and hip fractures. In the United States, strontium ranelate is not approved by the FDA. In the United Kingdom, the British National Health Service does not use or pay for strontium ranelate as a medicine, because other drugs were determined to be more economical.[1].

The writer used NICE guidelines to substantiate their statement that Strontium Ranelate is not prescribed on the NHS in the UK but this person cannot have read NICE guidance properly. First of all NICE guidance is simply guidance, not NHS law, and secondly the NICE guidance says Strontium Ranleate should only not be first line of treatment for osteoporosis but given when other, cheaper, treatments have failed or are not tolerated. It does not prohibit the prescription of Strontium Ranelate. This 'guidance' is also currently under review and was the subject of a High Court hearing in February 2009.

I changed the paragraph to:

Strontium ranelate is registered as a prescription drug in more than 70 countries for the treatment of post-menopausal osteoporosis to reduce the risk of vertebral and hip fractures. In the United States, Strontium Ranelate is not approved by the FDA. In the United Kingdom, Strontium Ranelate is prescribed under the National Health Service as a medicine for the treatment of post menopausal osteoporosis.[1].

My link to NHS Choices which describes treatments for osteoporosis with reference to Strontium Ranelate: http://nhs.medguides.medicines.org.uk/nhs/medicine.aspx?name=Strontium%20ranelate&use=Osteoporosis

Paleogirl (talk) 18:09, 20 May 2010 (UTC)

Contraindications

This statement of fact requires clarification. It is also misleading:

Precaution is advised in patients with phenylketonuria, as strontium ranelate contains phenylalanine

Strontium ranelate in of itself does not "contain" phenylalanine as part of its structure, and to make such a claim even if it did would be inaccurately put. The formulation containing strontium ranelate that is administered may contain phenylalanine (or a chemical that liberates phenylalanine such as aspartame) but this is simply not clear from the original statement.

Upon following the sources list, the formulation is referred to as a "sugar free" preparation, supporting the idea that the formulation contains a source of phenylalanine. —Preceding unsigned comment added by 77.86.75.231 (talk) 19:27, 25 May 2010 (UTC)

withdrawing

The marketing of the drug will be halted in the months to come, at least in France and E.U. . Toxicity, cardiovascular especially , outweighs the therapeutic benefit. (https://www.vidal.fr/actualites/21036/protelos_ranelate_de_strontium_prochain_arret_de_commercialisation/)90.83.38.167 (talk) 12:40, 15 March 2017 (UTC)