Talk:Stigmasterol/Archive 1

Archive 1

COPYVIOs by disruptive IP-hopping anonymous editor

I reverted the reintroduction of a tangential WP:COPYVIO paragraph to the "Uses" section by persistently disruptive IP-hopping anonymous editor 132.236.120.83 / 71.240.253.202
(aka 71.182.111.225 / 71.123.25.175 141.149.208.54 / 71.123.29.191 / 71.182.123.65 / 71.123.17.215 / 71.182.107.102 / 70.16.52.193 / 70.16.61.75 / 71.182.100.111 / 71.240.244.35 / 71.123.31.25 / 71.240.247.110 / 70.16.49.248 / 71.182.108.43 / 71.182.98.194):

WP:COPYVIO re-added 22:45, 25 July 2012:

After too many price hikes in the barbasco Mexican barbasco trade, the steroid industry largely went to semisynthetic modification of the phytosterols from soybeans.
There are two common sources of sterols: the production of soybean oil leaves a waste rich in stigmasterol and sitosterol; the root tubers of Mexican barbasco contain diosgenin.
Progesterone could be obtained in good yields (about 50%) from diosgenin extracted from the Mexican yam Dioscorea species (barbasco) (page 239) or stigmasterol from soybean (page 256).

from Duke, James A. (1993). "Medicinal plants and the pharmaceutical industry". in Janick, Jules.; Simon, James E. (eds.) New crops; Proceedings of the Second National Symposium New Crops—Exploration, Research, and Commercialization, Indianapolis, Indiana, October 6-9, 1991. New York: Wiley, ISBN 0471593745, pp. 664–669:

After too many price hikes in the barbasco, the steroid industry largely went to semisynthetic modification of the phytosterols from temperate soybeans.

and from Trehan, Keshav (1990). Biotechnology. New Dehli: New Age International, ISBN 8122401295, p. 24:

There are two common sources of sterols: the production of soybean oil leaves, a waste product rich in stigmasterol and sitosterol; the roots of the Mexican barbasco plant contain diosgenin.

and from Dewick, Paul M. (2002). Medicinal natural products : a biosynthetic approach, 2nd ed. Chichester: John Wiley & sons, ISBN 0471496405, p. 264:

Progesterone could be obtained in good yields (about 50%) from diosgenin extracted from Mexican yams (Dioscorea species; Dioscoreaceae) (see page 239) or stigmasterol from soya beans (Glycine max; Leguminosae/Fabaceae) (see page 256).

Note: unlike the cited 1991 conference proceedings paper by James A. Duke, which said:

After too many price hikes in the barbasco, the steroid industry largely went to semisynthetic modification of the phytosterols from temperate soybeans.

a current pharmacognosy textbook:

• Evans, William Charles (2009). Pharmacognosy, 16th ed. Edinburgh: Saunders Elsevier, ISBN 9780702029332, p. 308, says:

Until 1970 diosgenin isolated from the Mexican yam was the sole source for steroidal contraceptive manufacture. With the nationalization of the Mexican industry, however, prices were increased to such an extent that manufacturers switched to hecongenin for corticosteroids, to other sources of diosgenin and to the use of steroidal alkaloids of Solanum species. Total synthesis also became economically feasible and is now much used. More recently, the economics of steroid production have again changed in that China is now exporting large quantities of diosgenin; it is of high quality, being free of the 25β-isomer yamogenin, although this is of no commercial significance, and is reasonably priced. Three of the many Dioscorea spp. found in China and used commercially are given in Table 23.2; the tubers yield 2% diosgenin, with the average content of diosgenin for the main areas of production (Yunnan Province and south of the Yangtze River) being 1%.

Lynn4 (talk) 17:38, 27 July 2012 (UTC)

There's an article that has been faked by its writers, so the following phrase should be deleted

" It was demonstrated that it inhibits several pro-inflammatory and matrix degradation mediators typically involved in osteoarthritis-induced cartilage degradation "

If you look for the article that states this affirmation (reference 10: "Stigmasterol: a phytosterol with potential anti-osteoarthritic properties"), look carefully fig 6 of the original article. That western blot has been faked, as you can see if you zoom the image and look carefully the bands. The white line around them mean that a modified intensity image has been superposed on the original bands, so the relation between beta-actine and IkBa changes "demonstrating" the authors theory. Look that careers 4 and 5 have no white line on IkBa detection but yes on beta-actine ones. Because of this, the relation between them adjusts to a fake reduction of IkBa presence. — Preceding unsigned comment added by 80.30.92.186 (talk) 23:50, 3 June 2014 (UTC)