Talk:Solenopsin

Could mention analogs being studied for psoriasis

eg. Fire Ant Venom Toxin Analogs Improve Psoriasis in Mice ? - Rod57 (talk) 13:46, 5 October 2017 (UTC)[reply]

Stereochemistry

The current stereochemistry of solenopsin A – the name (2S,6R)-2-methyl-6-undecylpiperidine and the corresponding structure image (initial revision), seem to be wrong, according to the article about solenopsins absolute configuration. There are cis (also named isosolenopsins) and trans isomers (solenopsins) A,B,C (different long alkyls), but they “always” have R configuration on piperidine carbon with methyl (coincidentally IUPAC-numbered 2 in all three cases), so solenopsin A should be (2R,6R)-2-methyl-6-undecylpiperidine (doi:10.1016/S0040-4020(01)85567-8, please note that the abstract image shows *synthetic* isomers (2S,6R) (3), and (2S,6R) (4); there's also (dated) review doi:10.1080/00304949609458571; latest studies show that that is not always true; and the all four isomers exist in nature, but those with 2R configuration are prevalent, doi:10.21577/0103-5053.20170153.) —Mykhal (talk) 15:58, 20 October 2018 (UTC)[reply]

I agree with your analysis. I've updated the image and other data in the chembox to be consistent for the (R,R) isomer. Perhaps an explanation about the fact that the other isomers do exist in nature, but are not the most prevalent one, can be added to the article. -- Ed (Edgar181) 20:22, 20 October 2018 (UTC)[reply]