Talk:Shiga toxin

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Untitled

about the "one amino acid difference" between stx1 from STEC and stx from Shigella, I have noticed some sequences from Genbank in the alignment that there are cases where the two genes can be identical, thus the one AA difference is not absolute and can be a little misleading. Does anyone else have similar findings? Linlifeng (talk) 22:36, 21 September 2011 (UTC)[reply]

Controversy

is at an honour to dub a toxin under your surname?
did you ask the 1,4 million people living in Shiga Prefecture if they want an association with a toxin? also we have to ask all Japanese people, do they wish something like that? — Preceding unsigned comment added by 2A02:2149:821E:7800:F93C:28ED:282B:C51B (talk) 20:12, 14 June 2018 (UTC)[reply]

Use "stx" not the full name. Also, is the naming of the taxon Shigella a problem to you? --SCIdude (talk) 09:46, 10 December 2021 (UTC)[reply]

section: mechanism

please create a section:medical use for the potential cancer therapy use, it makes no sense in the mechanism section.

("The bacterial Shiga toxin can be used for targeted therapy of gastric cancer, because this tumor entity expresses the receptor of the Shiga toxin. For this purpose an unspecific chemotherapeutical is conjungated to the B-subunit to make it specific. In this way only the tumor cells, but not healthy cells, are destroyed during therapy").

89.134.199.32 (talk) 23:17, 5 September 2018 (UTC).[reply]

Adaptive function?

Is there any understanding of the circumstances in which production of this toxin is adaptive? (Presumably there's little benefit to the bacterial species from giving human hosts a hard time?!) What's the payoff from the metabolic investment in producing these fairly complex molecules? 2A04:B2C2:805:5600:C1C5:F597:71E4:399 (talk) 04:33, 16 June 2024 (UTC)[reply]