Talk:SUMO protein

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Please, give the phonetic transcription of the word "Sumoylation". 93.81.94.22 (talk) 20:02, 10 June 2009 (UTC) AnOther Observer[reply]

I can help: soo-muh-lā-shun

Source: This is how my rotations lab members who study SUMOylation, including our PI, pronounce it. Salient.Masonry (talk) 20:01, 23 October 2024 (UTC)[reply]

deleted sentence fragments

I deleted the following from the SUMO attachment section. It should be converted to full sentences with citations if it is relevant and correct.

balance SUMO equilibrium is important for the cell. Reduced or enhanced SUMOlyation will lead to onsets of cancers, for example, prostat cancer lead to eleveated expression of SENP1 or SENP3, breast cancer increased modification of SUMO targets via, (I)induction of Ubc9 E2 ligase (II)PIAS3 E3 ligase (III)cocurrent decrease in SENP6

Biolprof (talk) 17:40, 17 August 2012 (UTC)[reply]

SUMO protease activity is not ATP-dependent. E.g. the E1 activity is, I guess that was confused. I removed the wrong parts and leave it to the author to rephrase the sentence with regards to the ATP-dependence of other processes relevant here.

--Felix Tritschler (talk) 15:49, 19 October 2012 (UTC)[reply]

Role in Regenerative Medicine

SUMOylation is an important component in many biological processes, and it has applications in developmental biology as well as regenerative medicine which I would like to personally explore in order to at least briefly mention and share new information here:

Neural stem cells
Stem cell maintenance
Skeletal development
Embryonic stem cells
DNA methylation
Cardiology

What this topic page represents is a key fundamental process in biology which may aid researchers in making patients' lives better. I will do my best to make it approachable, and I will at least attempt to improve the organization of this page in the process.

To quote a publication, "More than 53 000 unique SUMOylation sites have been identified in human proteins."

Source: Andrew Vargas Palacios, Pujan Acharya, Anthony Stephen Peidl, Moriah Rene Beck, Eduardo Blanco, Avdesh Mishra, Tasneem Bawa-Khalfe, Subash Chandra Pakhrin, SumoPred-PLM: human SUMOylation and SUMO2/3 sites Prediction using Pre-trained Protein Language Model, NAR Genomics and Bioinformatics, Volume 6, Issue 1, March 2024, lqae011, https://doi.org/10.1093/nargab/lqae011

Any advice in this regard would be most welcome!

Cheers,

SM Salient.Masonry (talk) 18:04, 1 October 2024 (UTC)[reply]

I evaluated the article per the recommended training questions as follows:

Does the lead include an introductory sentence that concisely and clearly describes the article's topic?

Yes, and it seems well executed.

Does the lead include a brief description of the article's major sections?

It does not cover all of them but it does have a decent start on introducing each.

Does the lead include information that is not present in the article? (It shouldn't.)

I do not see anything extraneous in this article.

Is the lead concise or is it overly detailed? It seems as though there may be room to be more direct about each section, and could do with some transitions.

Is the article's content relevant to the topic?

Yes, it is on-topic.

Is the content up-to-date?

I do not see anything outdated per se, but there is more to add.

Is there content that is missing or content that does not belong?

I feel that SUMO protein's implications in human disease have been largely ignored in this article.

Does the article deal with one of Wikipedia's equity gaps?

I do not think that equity has a context in this article.

Does it address topics related to historically underrepresented populations or topics?

I believe that marginalized people are not and should not be discussed in this particular article, because it seems off-topic.

Is the article neutral?

I see no controversial aspects to this article.

Are there any claims that appear heavily biased toward a particular position?

I could not detect any reading through it.

Are there viewpoints that are overrepresented, or underrepresented?

I would like to see more areas of research included where and as that is feasible.

Are minority or fringe viewpoints accurately described as such?

I saw none of these sorts of viewpoints expressed.

Does the article attempt to persuade the reader in favor of one position or away from another?

I take the article's overall tone to be more matter-of-fact, and not so much as though it is actively trying to steer the reader toward a certain way of thinking.

Are all facts in the article backed up by a reliable secondary source of information?

Most are, and I can address a place where citations are needed.

Are the sources thorough - i.e. Do they reflect the available literature on the topic?

There are 25 referenced sources, and even more for additional reading, but there can certainly be more.

Are the sources current?

The source material is from 1996 to 2015. I am not sure its worth removing old sources, but it may be worth adding in new papers and some a year or so old.

Are the sources written by a diverse spectrum of authors? Do they include historically marginalized individuals where possible?

I believe so. It seems that at minimum, both European, Hispanic, and Asian names are in the papers referenced. I can't tell very well whether historically marginalized people are included here, or even how this metric is best evaluated.

Are there better sources available, such as peer-reviewed articles in place of news coverage or random websites? (You may need to do some digging to answer this.)

I know I could find more recent publications for several points made in the article.

Check a few links. Do they work?

The links are in working order as far as I can tell.

Is the article well-written - i.e. Is it concise, clear, and easy to read?

It seems so, but I see locations in which it could be better.

Does the article have any grammatical or spelling errors?

Is the article well-organized - i.e. broken down into sections that reflect the major points of the topic?

Does the article include images that enhance understanding of the topic?

There are only two protein structure images, and they do not necessarily help illustrate concepts. As a matter of fact, I made a few images myself using Biorender and I believe they convey what is essentially the canonical pathway for SUMOylation.

Are images well-captioned?

They are, and seem to have some flow to them.

Do all images adhere to Wikipedia's copyright regulations?

I believe so, although a closer look may show me something I haven't yet seen.

Are the images laid out in a visually appealing way?

There seems to be little in the way of patterning here, but I expect I can find some areas to improve.

What kinds of conversations, if any, are going on behind the scenes about how to represent this topic?

I submitted a post to the talk page over a month ago, but I have yet to get any sort of feedback.

How is the article rated? Is it a part of any WikiProjects?

It is a B-class article, and is of interest to Molecular Biology.

How does the way Wikipedia discusses this topic differ from the way we've talked about it in class?

It is a foundational component of molecular biology, but it has not been directly addressed in our classes.

What is the article's overall status?

It has a good base established for discussing and teaching about SUMO, but it could use some attention in a few areas.

What are the article's strengths?

Good start on reference material, including papers from around the discovery of SUMO.

How can the article be improved?

More information on why SUMO is significant, especially ways it is implicated in human health.

How would you assess the article's completeness - i.e. Is the article well-developed? Is it underdeveloped or poorly developed?

The article is arguably underdeveloped, but it has good bones to which new material can be added where appropriate.

To best improve this article, I am looking to focus on listing and describing human pathologies and their link to the SUMO pathway. Which organ systems are affected, what the disease state is, and which proteins are targeted for SUMOylation or deSUMOylation in healthy vs. diseased. I hope to clarify for readers how and where SUMO is relevant.

~~~~ Salient.Masonry (talk) 05:03, 4 November 2024 (UTC)[reply]

Wiki Education assignment: Adv Molec Biol Bass-FSU-Fa24

This article is currently the subject of a Wiki Education Foundation-supported course assignment, between 27 August 2024 and 13 December 2024. Further details are available on the course page. Student editor(s): Salient.Masonry (article contribs).

— Assignment last updated by Salient.Masonry (talk) 18:01, 5 November 2024 (UTC)[reply]