Talk:SCIN

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Correction on discovery of adseverin/scinderin

Hi, I noticed that the current article states: "It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada."

However, the purification and characterization of this protein as adseverin were reported by S. Maekawa and colleagues between May 1989 and July 1990, prior to or at the same time as the first publication by Dr. Trifaro’s group in January 1990.

Here are the key references:

S. Maekawa et al., (1989) Purification and characterization of a Ca2+-dependent actin filament severing protein from bovine adrenal medulla. J Biol Chem 264(13):7458-65. https://pubmed.ncbi.nlm.nih.gov/2708371/

S. Maekawa & H. Sakai (1990) Inhibition of actin regulatory activity of the 74-kDa protein from bovine adrenal medulla (adseverin) by some phospholipids. J Biol Chem 265(19):10940-2. https://pubmed.ncbi.nlm.nih.gov/2162826/

Dr. Trifaro's group published their findings in January 1990:

A. Rodriguez Del Castillo et al., (1990) Chromaffin cell scinderin, a novel calcium-dependent actin filament-severing protein. EMBO J 9:43-52.

I believe the sentence could be revised to: "It was independently discovered as adseverin and as scinderin by the groups of S. Maekawa and Trifaro, respectively." What do others think? Mmishima (talk) 11:53, 15 October 2024 (UTC)[reply]