Talk:Reye syndrome

acetaminophen

There's a statement about the possibility that acetaminophen is a larger risk factor than aspirin. Normally, I would add a "citation needed" but there is a citation -- to an article that does not make that claim in the first place. I'm not sure what the right way is to clean this up.

The article claims that 1% of cases are correlated with aspirin consumption, only 1% of aspirin sales are for pediatric use, acetaminophen is the predominant pediatric medicine, and 6% of cases correlate with acetaminophen use. Although the article doesn't say what percentage of patients use acetaminophen overall, and the implication is that it's well over 6% (thus making the correlation with acetaminophen lower than with aspirin), it simply doesn't say one way or the other. I'm not trying to debate whether there's a link between either or neither of these, but there's no citation here. The article says nothing and implies nothing about the percentage of patients with and without the syndrome who use aspirin vs acetaminophen.Hagrinas (talk) 15:51, 21 March 2012 (UTC)

Someone help me

During my recovery from the flu, I've been applying salicylic acid topically as an acne medication. Yesterday, I had nausea, and two days ago, I threw up. At first I thought that these were only symptoms of the flu, but now that I've learned the link between sal. acid and Reye's syndrome, I think I might have it. Is there a 100% certainty? I mean, if you take salicylic acid while recovering from the flu, you WILL get Reye's syndrome?

Short answer is no. If you are concerned about your health I would seek treatment from a physician. ChillyMD (talk) 20:50, 28 January 2009 (UTC)

Slightly less short answer is that this is a forum about the article's content, not a forum for medical help. I appreciate that you have a legitimate need for information, but I'm simply stating the purpose of the Talk section. Hagrinas (talk) 15:54, 21 March 2012 (UTC)

Cleanup Required

First of all, there are five stages, not two. Also, the symptoms are vague and nonspecific. I'll get this section cleaned up in a jiffity when I have time. Right now is not a good time, at least not for me. Freddie 00:00, 17 March 2006 (UTC)

I'd like to see some information on normal times to progression. The reye's foundation says "it strikes quickly" but there is no information on how long the various stages normally last before moving on to the next one. We don't really know if this is a disease that will progress in a matter of hours, days, weeks, months, years, etc.--Crossmr (talk) 12:09, 11 September 2008 (UTC)

Mitochondropathy?

When I was a student at a tertiary neuroological centre, I was taught that Reye's syndrome is one of a family of mitochondrial diseases (mitochondropathies), which explains its multi-system nature and its predominant effects on liver and brain. Unfortunately this now lies well outside my field of expertise. Anyone elucidate? Thanks. Preacherdoc 13:57, 26 July 2006 (UTC)

• Reye+Syndrome at the U.S. National Library of Medicine Medical Subject Headings (MeSH) seems to agree with you ("It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and carnitine metabolism") though it doesn't categorize Reye's under Mitochondrial+Diseases at the U.S. National Library of Medicine Medical Subject Headings (MeSH). On the other hand, emerg/399 at eMedicine hedges a bit ("The pathogenesis is unclear, but it appears to involve mitochondrial dysfunction that inhibits oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host.") At Online Mendelian Inheritance in Man (OMIM): 212140 (primary carnitine deficiency), they use the phrase "Reye-like syndrome". And recent research (PMID 16725361) also seems to point in that direction. Probably worth a mention, both at this article and at mitochondrial disease. --Arcadian 17:33, 26 July 2006 (UTC)

These links mention how a virus might be causative, but doesn't give any hypothesis regarding the possible method by which salicilates have an effect. I'd love to hear some speculation. ThVa (talk) 19:51, 16 September 2008 (UTC)

Pepto-Bismol Connection

I've noticed that bottles of Pepto and its generic versions contain a warning about possibly causing Reye's Syndrome. Shouldn't this get a mention as well? BioTube 18:27, 9 September 2006 (UTC)

Pepto Bismol (bismuth subsalicylate) contains a salicylate compound in it. Since this article already says that salicylates precipitate the syndrome, there's no need to mention Pepto here. --David Iberri (talk) 14:46, 15 February 2007 (UTC)

Although I agree that there's no need to mention Pepto Bismol specifically, the article mentions aspirin as a possible cause rather than listing salicylates as a possible cause with aspirin as an example. Mentioning Pepto Bismol doesn't seem to be the appropriate way to rectify anything, but if there's a possible link to salicylates in general, mentioning Pepto Bismol makes no less sense than mentioning fruit. Before the era of perfect looking fruit in the supermarkets, bruised, irregular, or fruit with scars was a more regular part of the human diet. Salicylates were consumed at a higher level and are still consumed to a degree by those who never take medicine because plants form salicylates naturally as a reaction to that sort of damage. I don't see any reason to mention anything with salicylates aside from aspirin unless there's a citation somebody can give showing a possible link rather than a warning label. Warning labels exist due to the correlation between lawsuits and the lack of warning labels. Hagrinas (talk) 16:11, 21 March 2012 (UTC)

Fat in Liver

Currently, this symptom has links to fat and liver. Would it not be more logical for it to have a link to fatty liver, or is the fat in the liver caused by Reye's Syndrome not the same as fatty liver? --PBurns 22:17, 9 October 2006 (UTC)

Answered on user's Talk page. Fredil Yupigo ^{What has Wikipedia become?} 22:21, 14 October 2006 (UTC)

aspirin bias?

The current wikipedia entry for Reye syndrome is biased against aspirin as a potential risk factor, and this view seems to contradict the prevailing consensus of the scientific community on the subject. As a result, the entry has poor credibility, and should be edited.

Right now it looks like the article merely states two sets of facts, one: that aspirin has a tenuous connection to Reye's according to many studies (and for that matter Reye's seems to be nebulous in nature), and two: that The official reccommendations haven't changed to reflect these studies since an initial reaction in the 80s. —Preceding unsigned comment added by 75.73.70.113 (talk) 03:42, 28 February 2010 (UTC)

Treatment

How is the disease treated? Is the coma reversible? Jack Daw 18:45, 3 December 2006 (UTC)

I'm also curious as to how this is treated. This article doesn't even address it. Can this disease be treated? If so, what is most effective in treating it? -- THL 07:56, 21 December 2006 (UTC)

Agreed - the intro paragraph states that early diagnosis is critical, and that "with support" the prognosis is good. This begs the question, what "support" or other treatment is given to so vitally impact the outcome? — Preceding unsigned comment added by 76.88.95.56 (talk) 22:17, 3 November 2012 (UTC)

Not entirely copyvio

This page is partially a copyvio, but much content is original (e.g. by myself). Would not support deletion. JFW | T@lk 14:48, 20 February 2007 (UTC)

Upon closer inspection, the URL that Katka193 was concerned about leads to a Wikipedia mirror. That does not remove my concern that much of the text of this article is unwikified and potentially copied from another source. JFW | T@lk 08:24, 21 February 2007 (UTC)

sorry not sure where to put this, just making my contribution

- Someone please use these facts (as taught to us in medical biochemistry) to update the page - See 1983 study on this subject - Marked by dicarboxylic aciduria - During viral illness, stress hormones cause release of FA. - Salicylic acid (aspirin) binds carriers for these FA's (carnitine/CoA) - Build up of FA in mitochondria due to lack of carriers can lead to the dissolution of mitochondrial membranes and can even lead to cell destruction - Hexanoyglycine is the big marker for detection of this disease - Hexanogylcine results from glycine conjugation in an amide conjugation with the free fatty acid - Any questions, please ask I will try to check this later. —Preceding unsigned comment added by 66.49.47.34 (talk) 20:22, 23 November 2009 (UTC)

Omission

Beginning in 1980, the CDC cautioned physicians and parents about the association between Reye’s syndrome and the use of salicylates in children and teenagers with chickenpox or viruslike illnesses. In 1982 the U.S. Surgeon General issued an advisory, and in 1986 the Food and Drug Administration required a Reye’s syndrome-related warning label for all aspirin-containing medications.

For those that know the history, this passage fails to mention that around 300 children died unnecessarily in the U.S. because industry lobby groups fought long and hard for years against a warning label. This needs to be added to the article. Viriditas (talk) 11:25, 13 August 2010 (UTC)

{{POV-section}} added. Viriditas (talk) 11:30, 13 August 2010 (UTC)

I'm sure I don't have to remind you, but in a project such as Wikipedia, mere omission is far more likely then an actual whitewash effort. I'll try to track down some sources—I have a 1992 NYT article at hand, but that's it. Would you consider adding this information yourself? Fvasconcellos (t·c) 14:08, 13 August 2010 (UTC)

My apologies, I've changed the heading. I haven't added the information because I've been very busy in RL. But, since I've got your attention, please review the information contained in this source for accuracy: Pendergrast, Mark (2010). Inside the Outbreaks: The Elite Medical Detectives of the Epidemic Intelligence Service. Houghton Mifflin Harcourt. ISBN 0151011206. Relevant text is on pp. 188-191:

Starko submitted her paper to Lancet. It was rejected....Her results were subsequently tacked onto an MMWR summary article in July 1980...Four months later the MMWR followed up with verification...The following month, Starko's study was finally published in Pediatrics...In June the surgeon general issued an advisory and the FDA proposed a warning label on aspirin. The aspirin industry demanded more studies and successfully delayed a warning label on medication containing salicylates until 1986. From 1981 through 1985, more than 1,000 U.S. children contracted Reye's syndrome, with 291 deaths. Up to a third of the survivors probably suffered permanent brain damage...Reye's cases in the United States fell from a peak of 555 in 1980 to 36 in 1987, and finally to just 2 cases in 1997, by which time most children's medication no longer contained aspirin.[1]

The 1992 NYT article you refer to above,("Delay on Aspirin Warning Label Cost Children's Lives Study Says"[2]) is a news article about the results found in Davis DL, Buffler P (1992). "Reduction of deaths after drug labelling for risk of Reye's syndrome". Lancet. 340 (8826): 1042. PMID 1357433. {{cite journal}}: Unknown parameter |month= ignored (help) Viriditas (talk) 20:01, 13 August 2010 (UTC)

The PubMed link above has several articles on the subject, showing that the media was responsible for helping get the warning out to the public while the Reagan/Bush administration failed to act. Viriditas (talk) 20:17, 13 August 2010 (UTC)

Expired external links

These External links are no more:

• FDA Bulletin on Reye-Johnson Syndrome
  
• Reye's Syndrome website at Brigham and Women's Hospital

I tried searching the sites for displacement addresses, but just couldn't find them. I don't know what the editors had in mind when choosing these links, but perhaps one of these sites could stand as a substitution:

• "NINDS Reye's Syndrome Information Page"
  

National Institute of Neurological Disorders and Stroke
http://www.ninds.nih.gov/disorders/reyes_syndrome/reyes_syndrome.htm

• "Reye Syndrome"
  

MedlinePlus, U.S. National Library of Medicine, National Institutes of Health
http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=reye+syndrome

• "The Diagnosis and Treatment of Reye's Syndrome"
  

NIH Consensus Development Program, U.S. Department of Health and Human Services, National Institutes of Health
http://consensus.nih.gov/1981/1981ReyesSyndrome030html.htm

Yours, Wordreader (talk) 03:40, 16 June 2012 (UTC)

The name of the condition -- the winner is....

Formally, in the USA in professional research circles, it's Reye-Johnson Syndrome.

However, the popular name has three variations across the 'Net and two can even occur within a single site. Creditable sites, too.

REYE Syndrome: FDA, PubMed Health, American Journal of Public Health article, Western Journal of Medicine article, American Liver Foundation, National Institutes of Health, Medline Plus, Centers for Disease Control, Department of Health & Human Services, American Medial Association

REYES Syndrome: Medline Plus

REYE'S Syndrome: National Reye's Syndrome Foundation, National Institute of Neurological Disorders and Stroke, Mayo Clinic, Western Journal of Medicine article, National Institutes of Health, Medline Plus, Centers for Disease Control, American Medial Association

For further information, these items give a history of the discovery and naming of the condition:

"Tale of Triumph on Every Aspirin Bottle", The New York Times http://partners.nytimes.com/library/national/science/051199sci-doctor-reyes.html

"Reye's Syndrome; Because You Need to Know" National Reye's Syndrome Foundation, Inc. http://nrsfpublishing.org/sampler/sampler_RS_BYNTK.pdf

"REYE SYNDROME: The Decline of a Disease", Department of Health and Human Services, Public Health Service, Food and Drug Administration http://www.web-pub.com/library/brochure/reye-syd.html

All the best, Wordreader (talk) 05:25, 16 June 2012 (UTC)

The ICD-10 names it as Reye syndrome, and hence as WP:MEDMOS says we should I think we should follow suite. I'm moving this article, if you have a problem with it change it, I just can't be bothered waiting years for somebody to care about the name of this enough to talk to me. Fuse809 (talk) 08:34, 14 February 2014 (UTC)

Take a pill

The page mentions treatment, but says nothing about what it is... TREKphiler ^{any time you're ready, Uhura} 20:36, 7 October 2015 (UTC)

Confusing info

The first para states it is a rapidly progressing encephalopathy - through 5 stages to death - yet only 30% prove fatal - says early diagnosis is helpful but gives no treatment - so what stops the progression? --Iztwoz (talk) 08:48, 27 January 2017 (UTC)

Supportive care improves outcomes while the disease takes it course. Like in Ebola. Treatment is supportive and supportive care improves survival.

Mannitol is mentioned as a specific treatment for a certain complication. Doc James (talk · contribs · email) 09:01, 27 January 2017 (UTC)

Not sure what this is for?

Bibliography

• Ermias D. Belay, M.D., Joseph S. Bresee, M.D., Robert C. Holman, M.S., Ali S. Khan, M.D., Abtin Shahriari, M.P.H., and Lawrence B. Schonberger, M.D. (6 May 1999). "Reye's Syndrome in the United States from 1981 through 1997". N Engl J Med. Vol. 340. pp. 1377–1382. doi:10.1056/NEJM199905063401801.{{cite news}}: CS1 maint: multiple names: authors list (link)
• Crocker JFS (ed) (1979), Reye's Syndrome II: Proceedings of the International Conference on Reye's Syndrome, 1978, Halifax, Nova Scotia, Canada, New York: Grune & Stratton {{citation}}: |author= has generic name (help)
• Jay M. Meythaler, MD; Rajiv R. Varma, MD (January 1987). "Reye's Syndrome in Adults - Diagnostic Considerations". Arch Intern Med. Vol. 147, no. 1. pp. 61–64. doi:10.1001/archinte.1987.00370010065016.

Please explain? Doc James (talk · contribs · email) 13:14, 9 May 2018 (UTC)