Talk:Reelin/GA1

GA Review

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Reviewer: Tea with toast (talk • message • contribs • count) 22:58, 1 September 2011 (UTC)[reply]

Inital comments

I am in the process of reviewing this article, and it will probably take me a few days to comb through it all since it is a long article. In the mean time, I have found one or two items in need of attention that hopefully someone can address while I'm working on the rest of the article.

The section "Mechanism of action" is in need of organization. There are a lot of stray sentences floating about so that there is a lack of flow and I find it difficult to keep track of everything that is going on. I would like to see the section broken up into subsections, if possible, to highlight the major mechanisms.
The section "Function" could also use some more organization and subsection splitting.

I would appreciate if someone could work on those while I finish reviewing the rest of the article. Thanks. --Tea with toast (話) 22:58, 1 September 2011 (UTC)[reply]

Additional comments

I appreciate the excellent changes in reorganizing the "Mechanism of action" and "Function" sections. Well done! I have found additional items in the article that I feel need to be addressed:

In regard to images:

in the "Reeler lamination" image, please specify Normal (left), reeler (right) if that is correct (Right now, it could be confused for top vs bottom). I also feel more explanation is needed in the caption. The text states that the 2 major differences are in the cerebellum and in the laminar, but I don't feel the image captures that. What is the significance of the darkened lines found in the left image but not the right?
I don't feel that the video is all that convincing that something is wrong with the mouse. I would either put up an additional video showing a normal mouse to compare, or else state in the caption what to look for in the video. (Also, if someone was interested in redoing the video, it would be best to have the camera stationary, as it appears to be handheld-shaking)
I don't understand the "Intense reelin IR/ Punctate reelin IR" image, and don't find any corresponding text to go with it. I think it might be best to remove it since there is already a wealth of good images in the article.
In "Factors effecting expression" section, the introduction of "LG=licking and grooming" could be a cause of some head scratching. I am assuming that "LG" refers to maternal care. If so, please state this in the text. Also, the Western blot is not all that convincing. It is okay to keep it, but if there is a more convincing image that could be used, I would replace it.

Other items:

What is the importance of the section "Interactions" at the end of the article. Hasn't the VLDLR and ApoER2 info been stated already in the article? I would either move the sentences to another section or get rid of it.

Done – I agree that the interactions section is redundant. I have therefore copied the citations from the interaction to into the receptor section and removed the interaction section. Boghog (talk) 11:20, 3 September 2011 (UTC)[reply]

The last sentence of the "Alzheimer's" section: "Some authors consider the reelin pathway to be a link between the Alzheimer's disease and schizophrenia." What link? I have never heard of link between the two, and the content in those respective articles do not mention any link. Being that there is no evidence presented to support the claim (and the claim comes from an obscure journal), I would remove it.

Done – Links between reelin, schizophrenia, and AD have been hypothesized (see for example PMID 20417248 that is more recent and in a less obscure journal). However this link is still only a hypothesis so I have removed it from the text. Boghog (talk) 11:20, 3 September 2011 (UTC)[reply]

I will put this article on hold until these items can be address. Thus far, I am impressed by the depth of this article! --Tea with toast (話) 22:44, 2 September 2011 (UTC)[reply]

Hi. Thanks for your GA review of this article. I am far from an expert on Reelin, but I will try to do my best to respond to your suggestions. I have alerted the primary author of this article and hopefully he can participate. Cheers. Boghog (talk) 23:34, 2 September 2011 (UTC)[reply]

What's the status of this review? No comments in a month. Wizardman _{Operation Big Bear} 17:22, 6 October 2011 (UTC)[reply]

I have been waiting for the primary editor of this article, CopperKettle, to respond to the issues that have not yet been addressed. The user appears to have taken a leave of absence, although being that they appear to be a prolific editor, I doubt they are gone for good. I have alerted them on the Russian wikipedia [1], which appears to be the user's primary account. If I do not get a response in a week's time, then I will take care of the article myself. The article is good enough to pass GA, but I'm still concerned about the images. If I get no response, I think I will remove the images and content that I find questionable in order to pass it. It's just that I'd hate to do that if the images could be made beneficial. --Tea with toast (話) 04:58, 8 October 2011 (UTC)[reply]

That may be best, as said editor is clearly editing, but there remains no progress on the article since my last cmt. Wizardman _{Operation Big Bear} 16:04, 25 October 2011 (UTC)[reply]

Final review

GA review – see WP:WIAGA for criteria

Is it reasonably well written?
A. Prose quality:

B. MoS compliance for lead, layout, words to watch, fiction, and lists:
Is it factually accurate and verifiable?
A. References to sources:

B. Citation of reliable sources where necessary:

C. No original research:
Is it broad in its coverage?
A. Major aspects:

B. Focused:
Is it neutral?
Fair representation without bias:
Is it stable?
No edit wars, etc:
Does it contain images to illustrate the topic?
A. Images are copyright tagged, and non-free images have fair use rationales:

B. Images are provided where possible and appropriate, with suitable captions:
Please see comments above about the images and the captions that are needed
Overall:
Pass or Fail:
I am sorry to have to fail this article since the majority of the article is very solid and there are only minor things that prevent me from passing it. However, I don't feel I have enough expertise to make the changes needed, so I hope someone else can do that in the future. Once the items I have listed in this review page are addressed, the article should be prepared to be submitted to GAN. Thanks to everyone who has worked on this article! --Tea with toast (話) 16:37, 5 November 2011 (UTC)[reply]