Talk:Recombination hotspot

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Is there exactly one crossover per homologous chromosome pair per meiosis?

The article states

"Linkage disequilibrium has identified more than 30,000 hotspots within the human genome.[3] In humans, the average number of crossover recombination events per hotspot is one crossover per 1,300 meioses, and the most extreme hotspot has a crossover frequency of one per 110 meioses.[4]"

If I try to calculate the number of crossovers over the full single genome per single meiosis event, I get (30,000 hotspots / genome) * ( 1 / 1,300 crossovers per hotspot per meiosis) = 23.0769230769 hotspot crossovers per meiosis per genome. Note how closes this is to the number of homologous chromosomes (23). Is this coincidence? More specifically if we group the 30,000 hotspots per homologous chromosome type or number, will the following be true for each of the 23 groups of hotspots: the sum of the crossover frequencies over all hotspots within the same group or homologous chromosome will sum to 1 per meiosis? If this conjecture is true it explains why the bulk 30,000 (over the whole genome) divided by 1300 equals nearly 23, (since 23 homologous pairs times exactly one crossover per pair necessarily results in 23 total).

Also note I'm not a biologist or geneticist, just a curious individual... — Preceding unsigned comment added by 212.71.7.172 (talk) 00:52, 28 February 2019 (UTC)[reply]