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CC reference 2. If the ketone moiety is reduced to an alcohol and an acetyl ester formed, & (S) isomer resolved, duration is x 212 methadone in potency & it's T½ is >48 hours so, like ORLAAM, only 3 doses a week would be required and along with an antagonist, 28 day implants (maybe upto 3 months?) would be possible. It would blockade the receptors like methadone is supposed to but in this case, it WILL work. Modern technology could include RFID to check data and work like being 'on tag'.
I'm not going to discuss the morals but I do think it's inclusion on the page would be of benefit. I cannot see it being a drug of abuse due to onset & duration. An added possibility would be that the dosage could slowly go down over the 3 months. Maybe not to 0, but to a level at which a partial agonist like thienorphine could be used for a further 3 months. 6 months is enough to make the gradual reduction much smoother & of course precludes the use of illegal opiates.
I know an Australian team developed a nalmefene implant that lasted for 6 months so after a 6-month detox, a further 6 months on blockers would give those dependent on opiates the very best chance of getting clean and remaining clean. We know that 90% of relapses occur in the first year so, if bail conditions included a DTTO, people could be on implants for a number of years.
The US system of payment seems crazy. The social harm alone must be worth the cost of the drug many times over. The crime, the loss of a family member or friend makes it seem, to me at least, like the least costly treatment. I haven't added it to the page because I want a few more experienced people to give some feedback. I did this on the Viminol page and someone kindly put up the data in a better manner than I would have. — Preceding unsigned comment added by 81.99.74.135 (talk) 21:22, 22 January 2017 (UTC)[reply]
