Talk:Prp24

A fact from Prp24 appeared on Wikipedia's Main Page in the Did you know column on 13 April 2009 (check views). The text of the entry was as follows:

Did you know... that a mutation in the human homolog of the RNA splicing protein Prp24 (pictured) is believed to cause the skin condition disseminated superficial actinic porokeratosis?

A record of the entry may be seen at Wikipedia:Recent additions/2009/April.

Molecular Biology: Genetics / MCB

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abbreviation?

What is the name the abbreviation of? Circeus (talk) 15:21, 5 April 2009 (UTC)[reply]

Good question. Now answered. Sasata (talk) 17:30, 5 April 2009 (UTC)[reply]

General jargon and legibility comments

The first that comes forth is that the intro clearly ("Found in eukaryotes from yeast to E. coli, fungi, and humans [...]") says the protein is found in humans, while later pretty much the opposite is implied ("Prp24 has a human homolog, SART3. [...] The RRMs 1 and 2 in yeast are similar to RRMs in human SART3.")
"Prp24 has been shown to promote the recycling of U4 and U6 snRNPs."
- I have replaced "recycling" in this sentence because it was really confusing: one normally uses "recycling" when a product goes into a different process (at least, from the point of view of somebody not literate in the intricaly of molecular biology).
"The C-terminal motif is required for association with LSm proteins and contributes to substrate (U6) binding and not the catalytic rate of splicing"
- This is complete jargon, and how both are suposed to be opposed is non exactly evident. Most likely, it culd do without "substrate" confusing things unhelpfully.
I removed subsections in "interaction". They were not large anough that they did anything really useful.
"The LSm proteins are in a consistent configuration on the U6 RNA."
- I simply cannot make heads nor tails of this and how it is relevant.
I dropped the "p110" bit, which is basically an alternate name for SART3, but here is just unnecessary and potentially confusing (it sounds like it's a specific part of the protein).
"It has been proposed that SART3 target U6 to a Cajal body or a nuclear inclusion as the site of assembly of the U4/U6 snRNP."
- This enire sentence (bare the fact there is a link to an article that is only minimally helpful) might as well be written in Chinese-rendered Hebrew.

Circeus (talk) 21:23, 5 April 2009 (UTC)[reply]

Thanks

Thank you guys for your input!! This is the first wikipedia page that I have ever made. It was for an assignment in a class that I have and although I may know a bit about the subject, putting it onto a web page for everyone to see was a little bit nerve racking. Your edits and comments are greatly appreciated! Mandmw (talk) 19:26, 5 April 2009 (PDT)

Despite my criticism, I think you did very well for a first try on such a technical topic (writing on those is always hard!). Hopefully you'll do more ;-) Circeus (talk) 03:06, 6 April 2009 (UTC)[reply]