Talk:Prednisone

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Used after heart valve transplants?

Is this drug used to prevent rejection following cadaveric heart valve transplants? —Preceding unsigned comment added by 124.169.242.226 (talk) 14:25, 7 August 2010 (UTC)

Correction

I'm just deleting a line within the article -

Other side effects include osteoporosis,reduced immune response,hunger,emotional efects and gassiness.

Osteoporosis is mentioned in the previous sentence, and immune suppression is discussed earlier in the article, so it's a redundant sentence.

Cheers, Dylan.

Corticosteroid misconceptions

Personally, I read a wack of things from linguistics to anatomy. I don't just read the nice happy-bunny stuff, but I enjoy controversial things too that would make most people wince. Guess I'm weird. One funny internet myth that I detect from my google searches is a dangerous confusion between corticosteroids and anabolic steroids.

While they are both types of "steroids", the name only refers to their chemical similarity, not their similarity vis-a-vis their functionality within the human body. There are many comical posts available online from people who unfortunately mistake these two very different chemicals. They honestly are mistaken in thinking that they are going to look like Arnold Schwarzennagger if they take prednisone. Yikes!

So I'm just thinking that since Wikipedia is meant to be NPOV in its information, it would be a positive move to add a section about popular myths and misconceptions like this one. (And I know, some may object to anyone taking steroids for bodybuilding because of many countries illegalizing its use for recreational purposes but again Wikipedia isn't about hasty puritanical judgement. It's just here to display facts to promote knowledge and education.) Dunno. Thoughts? --Glengordon01 04:34, 18 August 2006 (UTC)

There are generally misconceptions as to what the word "steroid" means. Plants produce steroids. Also, your talk page, and the "Arnold schwarzennagger" made me giggle. James.Spudeman 21:57, 24 February 2007 (UTC)

Topical corticosteroids

Could topical corticosteroids cause adrenal suppresion? —The preceding unsigned comment was added by Happathyapathy (talk • contribs) 03:39, 22 January 2007 (UTC).

Yes, all pharmacological, as opposed to physiological, doses of any steroid over enough time can cause adrenal suppression. In those cases subjects must be put on physiological doses of cortisone. typically a drug called Cortef or Cortenna is prescribed although any steroid could be used it has to be given at "natural" doses mimicking what the body would produce ordinarily. JasperLawrence (talk) 20:50, 6 August 2024 (UTC)

Increased sex drive

The article notes that prednisone can cause increased sex drive, which appears to be the opposite of what I find in a google search: prednisone reduces sex drive. I will edit accordingly. —The preceding unsigned comment was added by Ppe42 (talk • contribs) 02:05, 30 March 2007 (UTC).

Both can occur, it depends when one makes the observation.

Typically at the start of a course of steroids along with increased vigour one can see increased libido. But over time this diminishes and continues to diminish until libido is suppressed. JasperLawrence (talk) 20:53, 6 August 2024 (UTC)

Side Effects List

For each side effect listed, major and minor, two parameters are of interest: (a) the fraction of patients who would experience this side effect, and (b) the severity of this side effect on quality of life. A debilitating side effect that affects only a few could be as undesirable as a benign side effect that affects a majority. I wish someone could provide such additional information. —Preceding unsigned comment added by LoopTel (talk • contribs) 22:12, 10 November 2007 (UTC)

Is there a doctor in the house?

I'm a layman who requested a citation for a recently added statement in section Dependency, "For those on chronic therapy, alternate-day dosing may preserve adrenal function, thereby reducing side effects", simply because I have not heard of this approach before. The citation offered was "(see "Dosing Considerations")." I'm still somewhat uncomfortable after reading the citation, so I'm asking for a professional opinion: Does the citation support the statement? No disrespect intended to the original submitter, but I get antsy about broad statements that might induce someone to change their drug regimen, even if this is only Wikipedia. --CliffC 23:58, 8 May 2007 (UTC)

Please see the disclaimer: you should not be using WikiPedia for medical information, you MUST see a doctor! --Vlad|-> 22:01, 14 November 2007 (UTC)

Stay calm, I'm not counting on Wikipedia for accuracy in anything. As I say above, "No disrespect intended to the original submitter, but I get antsy about broad statements that might induce someone to change their drug regimen, even if this is only Wikipedia." It bothers me when I see postings where the poster repeats what he saw at some poorly-written source then can't come up with a decent citation, or worse yet, is just offering information based on personal belief. Thanks for responding. --CliffC 00:42, 15 November 2007 (UTC)

I'm calm, but you're right about a point: this is WikiPedia, the free encyclopedia that ANYONE (including you! :D) can edit. So of course I guess that if you think something is wrong, the best thing to do is to fix it! All the best! --Vlad|-> 20:36, 17 November 2007 (UTC)

What does "chronic therapy" mean? JasperLawrence (talk) 20:56, 6 August 2024 (UTC)

History

There may be a problem. My father, who died of Hodgkins Disease in 1962, was taking Prednisone (and later the generic hydrocortisone) for several years... and complaining bitterly about the high price of the former. Dick Kimball 06:18, 15 October 2007 (UTC)

new question

Perhaps someone can answer this question! I take pred for my cluster headaches! I have been on several tapers, the last one in June of this year! If I go below 10 mg. my headaches come back! If I stay at 10 mg. I have few or none! My question is, if I stay on 10Mg. is that dose enough to still effect the other bad things that come in higher doses?InsertformulahereThanks, EOD

Again, see my previous answer to a similar question: WikiPedia CAN NOT replace a real doctor! So only a doctor can give you an accurate answer to your question! --Vlad|-> 22:04, 14 November 2007 (UTC)

I agree with the above, you need to see a doctor. All I can tell you is my own experience - I have just re-started prednisone for a recurring erythema nodosum, and in my previous attempts to wean off the drug, if I ever went down below 5 or 10 mg/day, my condition sometimes would have a rebound flare-up. Even at 5 mg/day, there can be long-lasting side-effects, such as osteoporosis, and lingering Cushing's Sydrome. Talk to a doctor or a pharmacist. — Preceding unsigned comment added by Shanninsky (talk • contribs) 11:48, 25 July 2011 (UTC)

Capitalization

This article mainly uses P/prednisone at the beginnings of sentences. It's hard to tell whether it is a proper name or not ... I'll use a non-wiki source to figure it out. Boris B (talk) 23:11, 22 February 2008 (UTC)

Good point. Prednisone isn't a proper name. I'll try to reword a sentence to illustrate this fact. WDavis1911 (talk) 20:16, 24 February 2008 (UTC)

History, again

Hate to nitpick, but this sentence:

"Prednisone was invented in the early 1950s when Arthur Nobile at Schering, strep throat demonstrated that the side-effects of cortisone, such as water retention, high blood pressure and muscle weakness, could be removed by oxidisation of the drug through exposure to microbes."

...just doesn't parse. Some words are needed between "Schering" and "strep throat," otherwise it makes no sense. Thanks. --User:Myles Callum —Preceding unsigned comment added by MylesCallum (talk • contribs) 06:22, 26 October 2008 (UTC)

You're not being picky - you just found an random nonsense edit from a few weeks ago. Fixed now. -- MarcoTolo (talk) 20:22, 26 October 2008 (UTC)

Ceruloplasmin

Can anyone confirm that Prednisone can increase Ceruloplasmin levels? —Preceding unsigned comment added by Tradingbr (talk • contribs) 17:49, 16 September 2009 (UTC)

Prednisone for the eyes

My eye doctor uses Prednisone for my PIC. I thought it was just to help with my Avastin injections in my eye, but according to this article it looks like he is trying to prevent the primary problem of the PIC-- which is my white blood cells destroying my retinas. Does anyone have any actual documented information about this? Thank you. KatTrombone (talk) 16:22, 11 November 2009 (UTC)

Prednisolone Acetate (produced as a 1% ophthalmic suspension by Allergan) is also used following cataract surgery in some cases.32.97.110.56 (talk) 19

09, 30 April 2010 (UTC)Dave

Apparently it is also used to treat post-operative PRK eye surgery (e.g., brand name Pred Forte) as eye drops, to avoid scar tissue formation during healing. —Preceding unsigned comment added by 207.81.141.90 (talk) 21:56, 1 October 2010 (UTC)

prednisone side effects

Prednisone taken for long periods &/or high doses has very serious side effects not emphasized in the general article. My husband has both legs amputated above the knee [infected again], blind, impotent & internal damage such as an enlarged heart. The worse result was the masking of diabetes until it was too late. prednisone diabetes coricosteroids cvro--Buddyboy999 (talk) 16:30, 13 December 2009 (UTC)

What is considered "long term" use of prednisone? My husband has been on it for 2/12 - 3 months. This med causes brittle bones and my husband just broke a rib by cleaning the toilet. I've noticed mood swings as well as adema in his ankle. From discussing the matter with family members who are in the medical profession, a mild antidepressant is commonly prescribed with Prednisone. At what point in time is that supposed to happen?

Malia —Preceding unsigned comment added by 63.171.1.2 (talk) 17:14, 11 May 2010 (UTC)

He has been on it long enough or too long, unless there is no option. When you start taking drugs to suppress the side effects of other drugs it is time to look at different approaches.

Mood swings are a common side effect, as is oedema. JasperLawrence (talk) 21:02, 6 August 2024 (UTC)

COPD

My Mother's Doctor insist that she has COPD and prescribes Prednisone to treat it, which in turn drives her blood sugar above 400. I have not seen anything that indicates Ped as a treatment for COPD. Is it used for COPD? —Preceding unsigned comment added by 71.203.157.54 (talk) 01:24, 30 June 2010 (UTC)

Yes it is, COPD is an inflammatory disease, and steroids like Prednisone is a powerful anti-inflammatory drug.

But it cannot be used long term, and he should be using it in the inhaled form so that doses are lower than with oral formulations.

Look at PubMed for research on this subject to inform your discussions with his doctors. JasperLawrence (talk) 21:04, 6 August 2024 (UTC)

New template added

I have added the expert template with hopes of getting some more eyes on this article to help clean it up and make it a better article. I came to this article for information as a reader not an editor and found it to be of no use to me as it is, sorry. I will also notify the wiki projects listed above that may have an interest in this article. Thanks, --CrohnieGal^Talk 12:54, 11 August 2010 (UTC)

Half-life of 1 hour?

Who put that the half-life of prednisone is 1 hour? I don't think that is true, and it concerns me because 1-2 hours is the time of peak bio absorption. The half-life is 3.4 to 3.8 hours. This drug is active in humans for almost 36 hours: how could that be with a half-life of only 1 hour? Makes no sense to me. A physician or Ph.D biochemist care to comment? Jack B108 (talk) 21:03, 11 September 2010 (UTC)

OK, I should have checked more carefully before the above post, as it appears that 1 h is the biological half-life of this drug. Perhaps the confusion is in that prednisone is not the active drug: its metabolite prednisolone is the important agent, and it has a longer plasma half-life. Jack B108 (talk) 21:17, 11 September 2010 (UTC)

OK, but the article should mention that the half-life of prednisolone is more important than the half-life of prednisone. Also, the wiki page for prednisolone says the half-life is 2-3 hours, yet my doctor and http://www.globalrph.com/corticocalc.htm both report that the half-life of "prednisone" (not specifying the active drug) is 18 to 36 hours. 99.28.64.176 (talk) 02:49, 23 December 2010 (UTC)Jack Schmidt (not Jack B108) 22 December 2010

The half life is simply the time for detectable quantities of the drug in the blood to half. So none of the above you say about half lives, particularly as it is a pro drug, are inconsistent. JasperLawrence (talk) 21:06, 6 August 2024 (UTC)

References

History again

Is there a source for this?

"The patent though was stolen by Arthur Nobile and a patent war ensued, Nobile was fired from Schering Corporation, but the patenter name was never changed to Hershel Herzog and William Charney."

Pretty much everything I've found so far indicates that Nobile was the patenter and I've found no other mention of any "patent war" or other dispute. Could just be my failing at search engine navigation. Scott Stillwell, 26 May 2011 — Preceding unsigned comment added by 99.169.55.153 (talk) 06:14, 26 May 2011 (UTC)

can high dose 40mg+ cause facial hair to grow on women?

need to know considering stopping asap. thanks Vee71.11.163.246 (talk) 22:21, 29 August 2011 (UTC)

Please see our medical disclaimer: do not use Wikipedia to make medical decisions or for medical advice. -- John Broughton (♫♫) 23:32, 2 October 2012 (UTC)

Use the websites like WebMD and drugs.com to learn about side effects in detail, if that information is not on this page. JasperLawrence (talk) 07:58, 27 July 2024 (UTC)

first time

one time user should I be worried about side effects? — Preceding unsigned comment added by 76.103.52.47 (talk) 19:02, 14 October 2012 (UTC)

AS always with all drugs, and particularly yes with this one if you are on a long term prescription. Prednisone because of its side effects is typically and ideally only given for weeks or a few months. The higher the dose the truer this is. 10mg a day is a moderate dose, 50mg a day is a high one. Those are generalities and should not be used in place of a doctor's advice and management, and besides are body weight dependent. JasperLawrence (talk) 21:09, 6 August 2024 (UTC)

Micrograph context

The micrograph of a fatty liver is excellent, but is likely very difficult to interpret for those who are not used to studying histological sections of normal livers. The image would be more useful if a normal tissue section was included as a separate panel so that the reader can easily see the difference.

IUPAC name wrong?

I observe that the IUPAC name for Prednisone differs very substantially from Cortisone even though the only difference is a diene -> ene. IANAOC, and I know small changes in structure CAN lead to vastly different namings, but in this case, since the "front to back" nature of the molecule doesn't change, I am surprised by the profound difference. Can someone check this? — Preceding unsigned comment added by 71.109.148.145 (talk) 10:48, 2 February 2016 (UTC)

They are very different drugs, prednisone is, I believe, a lot stronger than cortisone. There is more to the differences than that alone. JasperLawrence (talk) 07:56, 27 July 2024 (UTC)

Important side effect (potentially fatal): Adrenal insufficiency/ failure

Include additional warnings : 1.Patients to carry steroid card/wear medical tag during treatment, and for up to 1year after cessation 2.Should not be stopped abruptly, due to risk of acute adrenal insufficiency (Addisonian crisis). 3.Should be weaned down/ off treatment only under medical supervision. 4.To seek medical attention/ advice in event of vomiting/ diarrhoea, due to risk of acute adrenal insufficiency from inadequate absorption of the tablets 5.Adrenal failure is sometimes permanent, necessitating adrenal steroid supplementation (cortisol) for life. 6.Untreated adrenal failure / acute insufficiency is fatal. 7.Prescribers should counsel patients regarding this matter. — Preceding unsigned comment added by 188.30.120.160 (talk) 08:20, 1 January 2017 (UTC)

Prednisone

What is the residual in the body after stooping prednisons? 2600:1006:A110:A1A9:657D:EB20:C03D:9F91 (talk) 16:06, 11 November 2022 (UTC)

can it help with a sore throat?

Bold 2601:582:300:62A0:D6FC:6759:3513:F8F5 (talk) 06:21, 8 April 2024 (UTC)

No one is going to give you medical advice, except that Prednisone is a prescription drug for a reason.

That taking an old pill is never a good idea and that using someone else's prescription is illegal.

That Prednisone is really strong, can cause serious side effects, including but not limited to death, and is not to be taken except under the supervision of a doctor.

And, never for a sore throat.

Maybe don't use so many medications if you want to be healthy. JasperLawrence (talk) 07:53, 27 July 2024 (UTC)

Prednisone vs Prednisolone

I am curious about what the two drugs are given separate pages.

My understanding is that Prednisone and Prednisolone are the same drug, essentially. That Prednisone is the prodrug to Prednisolone via enzymatic degradation by the liver.

I take it that this question came up a long time ago in the dawn of time?

But if they end up as the same drug via the process above, then consolidating them into one page seems to me to make more sense than having two pages. It would make comparisons of what have to be minor differences, nor not, and the discussion of the differences between the two drugs more efficient.

Having said that I also understand that isn't a hill I or anyone else wants to die on.

But, I think the subject of a comparison of the two is deserving of its own page assuming amalgamating the two pages is not a possibility.

The history of prodrugs, like Prednisone, is not always a happy one. See Phenacetin the prodrug of Paracetamol (Tylenol in the USA). Phenacetin was banned in 1984 (I think it was'84). Because if you lacked the gene/s that produced the specific enzyme required to convert Phenacetin to Paracetamol death could and did result.

There has to have been papers at the very least written on the subject, and probably news articles, for references.

Don't hit me, please.

https://www.drugs.com/medical-answers/difference-between-prednisone-prednisolone-3508888/ JasperLawrence (talk) 07:48, 27 July 2024 (UTC)