Talk:Pharmacophore

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Molecular Biology: MCB

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Origin of term

According to John van Drie at http://pharmacophore.org/, the origin of the term pharmacophore should be attributed to Monty Kier, not Ehrlich: "The concept of a p,nk,nharmacophore is widely but erroneously believed to originate from Ehrlich in the early 20th century, a mistake due to Ariens, propagated by P. Gund, and further propagated by O. Guener"

Wikipedia should go by whatever is verifiable in a reliable source. So if there are journal references, for example, that support van Drie's statement, it could be incorporated into the article text. -- Ed (Edgar181) 18:36, 1 November 2008 (UTC)[reply]

All of my statements are supported by exhaustive journal references, in the IEJMD article whose link precedes the words cited above. Proving a negative (ie proving Ehrlich never coined the term pharmacophore) is always difficult. It is a trivial matter to verify the Ehrlich citation is incorrect - just walk to a nearby old chemistry library containing that journal, and you won't find the quoted text in that article. In that IEJMD article, I cite numerous references in my attempt to show that the term originates from Kier, not Ehrlich. I would like to simply totally revamp this Wikipedia page; I know more about this subject than almost anyone. Should I just do that? JHvD (talk) 18:36, 27 July 2009 (UTC)[reply]

If there are errors, this page should be rewritten. I would suggest that you retain and identify the errors so that readers can appreciate how misconceptions have crept into the literature. I would appreciate seeing all the references; it just adds to the credibility of the contribution. Nakatsuk 12:55, 22 October 2010 (UTC) —Preceding unsigned comment added by Nakatsuk (talk • contribs)

I have changed the article according to the suggestions of van Drie. I am not a native speaker und would appreciate it someone find time to proof-read the changes. I read the whole publication by Paul Ehrlich (I am German) and can confirm that they do not mention pharmacophores or any related concept. HerrMarder (talk) 12:47, 31 January 2011 (UTC)[reply]

Please read the article: "Setting the Record Straight: The Origin of the Pharmacophore Concept," J. Chem. Inf. Model. 2014, 54, 1269−1283 for a scholarly investigation of the origin of the concept. 88.230.49.104 (talk) 14:27, 16 May 2022 (UTC)[reply]