Talk:P300-CBP coactivator family

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Hedgehog33 04:10, 23 February 2007 (UTC)[reply]

Merger

Regarding the proposed merger of EP300 into P300/CBP, as the the two proteins P300 and EP300 are identical, I support the merger. In addition, since the P300/CBP page is essentially a superset of the of the information contained in the EP300 page, I suggest that we replace the EP300 page with a redirect to P300/CBP. Boghog2 20:42, 25 June 2007 (UTC)[reply]

I do not support the merger. I agree that P300 and EP300 are identical, but the P300/CBP article deals with common features of two distinct proteins, EP300 and CREBBP (also called CBP). I'd suggest leaving all three articles, but put the majority of the gene-specific information on the individual gene pages. AndrewGNF 03:51, 9 October 2007 (UTC)[reply]

I have now changed my mind and support keeping all three pages. Cheers. Boghog2 (talk) 07:18, 4 April 2009 (UTC)[reply]

De-merging and renaming

De-merging: As AndrewGNF pointed out above, CPB (CREBBP) and p300 (EP300) are two related but distinct proteins each encoded by a different gene. Therefore a separate article for each is justified. In addition, there is frequent reference in the literature to the p300/CBP protein family which was the reason why this article was created. I have therefore restored and expanded the CREBBP article and moved the CREBBP {{PBB}} template from this article back to the CREBBP article. This article which is about the protein family contains the more compact {{protein}} templates while the gene/protein specific articles contain the more complete {{PBB}} templates.

Renaming: The p300-CBP Transcription Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) entry is somewhat inappropriately named since neither CBP nor p300 is a transcription factor (neither directly bind to DNA and hence by definition are not transcription factors). These proteins are more properly classified as coactivators. Therefore I have renamed this article as p300-CBP coactivator family to more accurately reflect the subject matter of this article. Boghog2 (talk) 11:45, 4 April 2009 (UTC)[reply]