Talk:Olanzapine/fluoxetine

R from related word discussion

Symbyax is a brand name used by Pfizer in marketing a combination of Fluoxetine and Olanzapine. There are a number of combination drug article in Wikipedia and if one is created for this combination, the redirect should be so retargeted. The current target is based on there being more treatment of Symbyax in the 'fluoxetine' article vs. the 'olanzapine' article. I'm not sure, but it is also likely that fluoxetine is considered the primary active in symbyax, with olanzapine added to alter the effects of fluoxetine (need pharmacologist input to verify that). --User:Ceyockey (talk to me) 17:30, 18 December 2006 (UTC)

Tis an article now

I welcome assistance.Persephone12 (talk) 21:46, 17 July 2010 (UTC)

Some thoughts

Some things I did to the article (and you might find interesting for your future article creations and expansions):

• I moved the article to the International Nonproprietary Names, as described in Wikipedia:WikiProject Pharmacology/Style guide#Standard drug combinations.
• I also included a {{drugbox}} and did some copyediting, like changing the section headers to lower-case in accordance with the Wikipedia:Manual of Style.
• Another issue (partly) resolved: In general, words should only be linked once. I removed most of the links to the olanzapine and fluoxetine pages.

Things you could do to improve the article:

• For a higher rating than Start, I'd suggest having a look at Wikipedia:WikiProject Pharmacology/Style guide, especially the part on sections that a drug article should ideally contain.
• You could also fill in some of the important fields in the drugbox (ATC code if there is one, pregnancy category, route of administration, legal status).

Hope this helps. Happy editing! ἀνυπόδητος (talk) 22:32, 17 July 2010 (UTC)

Thanks a bunch for the help, I really had no idea how to deal with some of it, especially since it was a combination of drugs. Persephone12 (talk) 22:46, 17 July 2010 (UTC)

How detailed should this article be?

I am not really sure, because I feel like adding much of the info typical to drug articles would essentially just be copying and pasting from olanzapine and fluoxetine. Thoughts? Persephone12 (talk) 22:56, 17 July 2010 (UTC)

You could refer the reader to the olanzapine and fluoxetine articles. What about something like

==Contraindications, adverse effects and interactions==

Contraindications, adverse effects and interactions are the same as for the constituent drugs.

You could add one or two of the most important items, and anything that doesn't apply to olanzapine and fluoxetine (e. g., if a side-effect has been described / is in the package insert that is not known for the ingredients). Sorry if that's a bit blurry, but we don't have the drug in Austria and I know virtually nothing about it that cannot be deduced from its parts. --ἀνυπόδητος (talk) 14:06, 18 July 2010 (UTC)

synergistic effects

Removed section on 'synergistic effects' of the combination of the two drugs, b/c the data given in the wiki entry does not appear in the associated citation. Moreover, claims along the lines of 'in a pre-clinical trial, xx% increase of [some neurotransmitter] was observed with drug X, yy% increase of [some neurotransmitter] was observed with drug y, and zz% increase of [some neurotransmitter] was observed when the two were used in combination' are woefully inadequate and misleading to appear in the wiki entry w/o further explication.

Very doubtful those numbers and claims pertain to in vivo measurements at the synaptic cleft in humans... although that is exactly what unsophisticated readers will assume. When the "catecholamine hypothesis" (or some variant thereof) is used in DTC advertising, it is highly misleading to make such statements without further additional information.

In future, please be much more forthright by providing both accurate citation and sufficient detail in the assertions themselves such that there is no ambiguity as to what experiments the measurements were derived from (in vivo/vitro, organism, method of sample collection and/or analyte detection, etc.)71.202.140.109 (talk) 10:55, 25 April 2012 (UTC)

External links modified

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