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[edit]

This article has a lot of external links which should be turned into regular references, like this one.[1] WhatamIdoing (talk) 03:04, 22 February 2008 (UTC)[reply]

References

  1. ^ http://en.wikipedia.org/Oklahoma_Medical_Research_Foundation

Conflict of Interest (CoI) notice

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My work on this page between 2 February to 31 August, 2019 is as a paid but unaffiliated consultant. I was hired as an outside, 3rd-party writer to improve this and related pages to Wikipedia encyclopedic standards, and to bring remedy to some of the prior concerns about single-source data. I have no other employment or financial relationship with the Foundation. DeknMike (talk) 02:43, 24 February 2019 (UTC)[reply]

Thank you for the transparent disclosure @DeknMike:, I have added the standardized template for this on top of this talkpage (please feel free to tweak it if necessary). Please also read the detailed information at WP:COI and WP:PAID, and suggest further changes in affected articles on article talk instead of editing these articles yourself. I'll post some additional links fyi on your user talkpage. GermanJoe (talk) 05:12, 24 February 2019 (UTC)[reply]

Contract is concluded, and I have been paid. I am no longer affiliated with OMRF, and no longer have a CoI. DeknMike (talk) 16:48, 29 January 2020 (UTC)[reply]

Some proposed changes

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Information to be changed: Change the title for the second section from 'Research' to 'Areas of Research' and add the following:

Edit request

From its beginnings, much of the research has been focused on understanding the nature of what made a person healthy, and understanding what happens when immunity malfunctions. [1] OMRF scientists continue to study how the human immune system forms — or fails to form — immune responses, and to create and test effective treatments.[2]

At one time, the Foundation operated a research hospital, where patients would come for ongoing study and experimental treatments. The 14-room hospital opened in July, 1951 and the first patient was Lillian Sims. [3] Other patients allowed researchers to study the effects of idleness and of nutrition. Many children came as a last-ditch hope in their waning days of serious illness.[4] The hospital closed in 1976 and now only does out-patient study and consults to nearby hospitals. [5]

OMRF uses a cross-disciplinary approach to medical research that has helped its scientists generate more than 700 U.S. and international patents.[6] The top areas of study are heart disease, Cancer, Diabetes, Alzheimer’s disease, and immune-response diseases such as Lupus, Sjögren's syndrome, Multiple Sclerosis and Arthritis[7] [8]

---end of edit--------

References

  1. ^ Young, W Landon (1998). Oklahoma’s Hidden Treasure. OMRF. p. 72.
  2. ^ "OMRF Awarded 14.5Million for Anthrax Studies". Global Biodefense. August 25, 2014. Retrieved May 9, 2019.
  3. ^ Young, W Landon (1998). Oklahoma’s Hidden Treasure. OMRF. p. 47.
  4. ^ Young, W Landon (1998). Oklahoma’s Hidden Treasure. OMRF. p. 50.
  5. ^ Young, W Landon (1998). Oklahoma’s Hidden Treasure. OMRF. p. 47.
  6. ^ "Federal grant brings $13.1 million to OMRF labs" (PDF). Innovate. July 2018. p. 5. Retrieved March 16, 2019.
  7. ^ "OMRF Annual Report 2017". OMRF. Retrieved 2019-03-10.
  8. ^ "Company Profile: Oklahoma Medical Research Foundation". Gerontological Society of America. Retrieved March 16, 2019. {{cite web}}: Cite has empty unknown parameter: |published= (help)

Explanation of issue: The purpose is to provide a summary of the overall goals of the OMRF. In a separate request, I will adjust some of the research paragraphs to reflect current status. DeknMike (talk) 03:23, 23 October 2019 (UTC)[reply]

 Not done The article already contains a large amount of information referenced by OMRI OMRF. I am disinclined to add more information which isn't referenced by reliable, WP:SECONDARY sources unconnected to OMRI OMRF or the healthcare industry.[a] Regards,  Spintendo  10:41, 24 October 2019 (UTC)[reply]

Notes

  1. ^ This is not predominantly information about OMRI's OMRF's history, which is innocent enough to be referenced by the company itself. When the claims have to do with areas of research in the present, I'd like reliable WP:SECONDARY sources to act as references.

Edit request

[edit]
Edit request
Revised 2d Paragraph of Lede

Request minor revision to 2d paragraph:

OMRF’s scientists (remove 'who include a member of the National Academy of Sciences,') conduct quality health research at lead to commercial products.[1] Together, they hold more than 700 U.S. and international patents and have spun off 11 biotech companies. Example discoveries at OMRF are technologies that led to Xigris (the first FDA-approved drug for the treatment of severe sepsis), Ceprotin (a therapy for people suffering from a rare and life-threatening blood disorder known as protein C deficiency) and the enzyme believed responsible for Alzheimer’s disease, which laid the groundwork for OncoVue,[2] a breast cancer risk assessment test.

DeknMike (talk) 18:25, 20 December 2019 (UTC)[reply]

Proposed Change to "In Society ' section

Recommend changing the last paragraph and renaming 'Funding'

OMRF is funded through individual contributions and foundation and government grants. Although most of the current funding is from federal grants, the bulk of the remainder comes from within Oklahoma.[2][3] In the early days, Oklahoma oil companies funded the majority of the work, although contributions also included passing donation buckets at college football games, farmers dedicating the profits from one acre of wheat, and even Foundation staff soliciting contributions on the city streets.[4] Memorial grants continue to play a meaningful role in funding, and social societies routinely make significant bequests. [5][6] All but the first of its seven buildings came from major gifts to the Foundation. [7]

Independent rating service Charity Navigator notes 91.1% of the charity's $75 Million of expenses are for the programs and services it delivers and only 6.1% on administrative expenses. Charity Navigator has a rating score that assesses financial health, accountability and transparency; for 2017, they assessed OMRF as Category 4 of 4 (the highest) with a score of 93.94.[2]

One of the more unusual contributions is a share in the royalties of the musical Oklahoma!. Lynn Riggs wrote one of the play's songs, “Green Grow the Lilacs.” When he died, he willed his 1% royalty to his 4 siblings. When his brother William Edgar Riggs died, OMRF received rights to that one-quarter share. As of the end of 2018, it has generated over $700,000 in earnings.[4]


New Leadership section

Recommending adding a new section about the President of the Foundation, titled 'Leadership'

Dr Stephen Prescott became President of OMRF in 2006. He had already established his credentials as a leader in studies of the basic mechanisms of human disease, authoring more than 250 scientific articles and training 40 research students and postdoctoral fellows. At the University of Utah, he founded the Eccles Program in Human and Molecular Biology & Genetics and was executive director of the Huntsman Cancer Institute. He has been elected to the American Association for the Advancement of Science, the Association of American Physicians, the American Society for Clinical Investigation, the Royal College of Physicians in Ireland, and the Royal Academy of Medicine in Spain. He is the founder of the biotechnology company LineaGen. [8] In addition to serving as President of a cancer research center, Dr Prescott also serves on medical and scientific advisory committees for the National Institutes of Health, the American Heart Association and the American Cancer Society. [9]

References

  1. ^ Katz, Bruce (April 25, 2017). "Converging possibilities: Oklahoma City's innovation district". The Brookings Institution. Retrieved December 20, 2019.
  2. ^ a b "Oklahoma Medical Research Foundation". Charity Navigator. August 1, 2018. Retrieved March 15, 2019.
  3. ^ Art Cotton (November 10, 2002). "Rural Oklahoma's commitment to medical research astounding". NewsOK.com. Retrieved March 10, 2019.
  4. ^ a b "'Oklahoma!' royalties: A gift that keeps on giving at OMRF". NewsOK. Retrieved January 25, 2019. Cite error: The named reference "Oklahoma! Royalties" was defined multiple times with different content (see the help page).
  5. ^ "Oklahoma Masonic Fraternity donates $1 million to OMRF". The Edmond Sun. April 20, 2009. Retrieved December 20, 2019.
  6. ^ Young, W Landon (1998). Oklahoma's Hidden Treasure. OMRF. p. 37-41.
  7. ^ Young, W Landon (1998). Oklahoma's Hidden Treasure. OMRF. p. 71.
  8. ^ "Texas A&M Science to Induct Three into Academy of Distinguished Former Students". Texas A&M University. 2016-03-21. Retrieved 2019-03-20.
  9. ^ Melissa Howell (2018-11-29). "OMRF's Stephen Prescott talks". NewsOK. Retrieved 2019-03-20.

DeknMike (talk) 21:06, 20 December 2019 (UTC)[reply]

Reply 28-JAN-2020

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  Edit request declined  

  • It was previously asked that reliable, independent, secondary sources be provided for this information. The sources provided thus far do not meet that expectation. In particular, sources from the OMRF — including one written by Art Cotton, who is the vice president of development for the OMRF — continue to be proposed to be added. These sources are unacceptable.

Regards,  Spintendo  23:54, 28 January 2020 (UTC)[reply]

Conflict of interest, sources

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Firstly, it looks as if the bulk of this article was added with this edit on 25 May 2007, and as if that edit was made by or on behalf of the institution itself ("Update from the organization"). Secondly, there are essentially no reliable, independent, secondary sources at all in the page (the few that are not to the website of the thing appear to be connected and/or press releases). I suggest we (a) remove the bulk of the self-references, other than those that verify basic facts such as where it is; and (b) remove whatever text then remains unsourced. The real question, of course, is whether there is enough solid independent coverage elsewhere for it to meet WP:NCORP – there certainly isn't here. Justlettersandnumbers (talk) 20:45, 29 January 2020 (UTC)[reply]

Improving the article's research section

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Hello,

I’d like to recommend edits to the Research section of this article. At present, this section is very out of date and some of the content in it is poorly sourced or has other problems. As an OMRF employee, I have a conflict of interest, so rather than editing myself, I am proposing them for review. I am grateful for your assistance and time. Also please note that there are a few sources which are either paywalled or not available online, so I’ve included the passages that support my proposed Wikipedia language where they appear.

Edit request 17-OCT-2024

First proposed change: In the Research section (Oklahoma Medical Research Foundation#Research), please insert the following sentences to make a new paragraph at the beginning of the section:

OMRF conducts its research across five different divisions: Aging & Metabolism,[1] Arthritis & Clinical Immunology,[2] Cardiovascular Biology,[3] Cell Cycle & Cancer Biology,[4] and Genes & Human Disease.[5]

Why it should be changed: This paragraph provides up to date information about how the foundation organizes its research clusters, and is supported by reliable sourcing.

Second proposed change: In the Oklahoma Medical Research Foundation#Alzheimer's and brain diseases subsection, please replace the existing content with the following two sentences:

In 2000, OMRF researchers created an inhibitor that, in vitro, stopped the enzyme thought to cause Alzheimer's disease.[6][7] In 2007, OMRF researchers found evidence of a molecular mechanism that links an Alzheimer’s susceptibility gene called “E4” to the onset of the disease.[8]

Why it should be changed: The present subsection is very poorly sourced, with much of the information having no source at all. Parts of it read like resumes for individual researchers, or are otherwise WP:PROMOTIONAL in tone. This new version is condensed and only contains information that can be confirmed by reliable press reports.

Third proposed change: In the Oklahoma Medical Research Foundation#Alzheimer's and brain diseases subsection, please add the following sentence to become the new third sentence, following the two sentences proposed in item 2.

In 2023, OMRF researchers began studying the connection between estrogen and Alzheimer’s in postmenopausal women.[9]

Why it should be changed: The current subsection is missing information past 2007. The suggested sentence uses a reliable source to summarize recent research at OMRF and helps to bring the subsection up to date.

Fourth proposed change:

In the Research section’s subsection, Oklahoma Medical Research Foundation#Alzheimer's and brain diseases, please change the heading from “Alzheimer's and brain diseases” to “Aging & Metabolism.”

Why it should be changed:

‘Aging & Metabolism’ is the current name of this research program at OMRF and this is how the press now refers to it. See: the Journal Record and The New York Times In this case, the name of the program is a “straightforward, descriptive statement of facts that can be verified by any educated person with access to the primary source but without further, specialized knowledge.” so can also be established with the OMRF website.

Fifth proposed change:

In the Oklahoma Medical Research Foundation#Cancer and immunobiology subsection, please replace the existing paragraph with the following version:

In 2003, OMRF researchers developed a genetic test for assessing breast cancer risk in women.[10][11] In 2006, OMRF researchers were able to reverse mitotic exit (cell division) in vertebrate cells.[12][13][14]

Why it should be changed: The existing version contains inaccurate or out of date information, is poorly sourced, and in places reads like a resume for individual researchers. This new version removes WP:TMI, provides reliable sourcing for all statements and focuses only on research findings from leading peer-reviewed journals.

Not all of the sources cited above are easily found online, so here’s the content from ones which are not readily available:

The Scotsman, 13 April 2006: 

A team led by Dr Gary Gorbsky at the Oklahoma Medical Research Foundation (OMRF) was able to interrupt and reverse cell division by manipulating a key protein.
The findings may prove important in controlling the development and spread of certain cancers. They also hold out the promise of prevention and treatment of birth defects and a wide range of other conditions.

Birmingham Mail, 13 Apr 2006: 

A team led by Dr Gary Gorbsky at the Oklahoma Medical Research Foundation (OMRF) was able to interrupt and reverse cell division by manipulating a key protein.
The scientists were even able to send duplicate chromosomes, the packages of DNA containing genes, back to the centre of the original cell that gave rise to them - an achievement previously thought to be impossible.
Dr Gorbsky, whose research appears in the journal Nature today, said: "No-one has gotten the cell cycle to go backwards before now."

Sixth proposed change:

In the Research section’s subsection, Oklahoma Medical Research Foundation#Cancer and immunobiology, please change the heading to “Cell Cycle & Cancer Biology”.

Why it should be changed: ‘Cell Cycle & Cancer Biology’ is the current name of this research program at OMRF and this is how the press now refers to it. See for example, the Journal Record. In this case, the name of the program is a “straightforward, descriptive statements of facts that can be verified by any educated person with access to the primary source but without further, specialized knowledge.” so can also be established with the OMRF website.

Seventh proposed change: In the Heart and blood diseases subsection, please replace the existing two sentences with the following:

In the 1980s, OMRF researchers conducted several studies on protein C and developed a treatment for sepsis which utilized activated protein C.[15][16][17]

Why it should be changed: This version provides information about OMRF research into protein C in the 1980s that eventually led to the development of a treatment which was later patented in 1991 and licensed to drugmaker Eli Lilly and Company in 1994. It’s an important highlight that merits inclusion in this article.

Eighth proposed change: The current version of the Oklahoma Medical Research Foundation#Lupus and autoimmune diseases subsection can be shortened into a brief paragraph comprising of the most important details, which unlike the present version, is supported by secondary sources rather than WP:PRIMARY websites:

In 1995, OMRF researchers established a national registry and data repository for studying the genetic causes of systemic lupus erythematosus.[18][19] In 2021, a study published in the International Journal of Environmental Research and Public Health found that over a 50-year period beginning in 1971, OMRF contributed the most publications on lupus in the United States.[20]

Why it should be changed: The existing paragraph is poorly sourced and contains both WP:TMI and some WP:PROMOTIONAL content. The proposed replacement rectifies those issues, and also replaces questionable WP:PRIMARY sources with a reliable press source and a relevant primary source, not to establish facts, but just for reference.

Ninth proposed change: In the Research section’s subsection, Oklahoma Medical Research Foundation#Lupus and autoimmune diseases, please change the heading to “Genes & Human Disease”.

Why it should be changed: ‘Genes & Human Disease’ is the current name of this research program at OMRF and this is how the press now refers to it. See for example, the Journal Record here. In this case, the name of the program is a “straightforward, descriptive statement of facts that can be verified by any educated person with access to the primary source but without further, specialized knowledge.” so can also be established with the OMRF website.

References

  1. ^ "OMRF adds two principal researchers". Journal Record (Oklahoma City). 12 February 2019. Retrieved 29 March 2023.
  2. ^ "Oklahoma researcher earns Lupus Foundation award". Journal Record. 3 February 2021. Retrieved 3 April 2023.
  3. ^ "OMRF receives $3.5 million to study blood clotting". Journal Record. 15 September 2020. Retrieved 4 April 2023.
  4. ^ "Presbyterian Health Foundation funds key research in OKC". Journal Record. 17 January 2023. Retrieved 3 April 2023.
  5. ^ "OMRF receives $1.2 million to study diseases of aging". Journal Record. 20 October 2020. Retrieved 3 April 2023.
  6. ^ Maugh II, Thomas H. (13 April 2000). "Researchers Identify Alzheimer's Enzyme Inhibitor". Los Angeles Times.
  7. ^ Cole, Carol (13 April 2000). "OMRF finds Alzheimer's inhibitor". The Journal Record. Retrieved 14 April 2023.
  8. ^ Archer, KIm (14 April 2007). "Oklahoman defines Alzheimer's problem: WHAT IS ALZHEIMER'S DISEASE?". Tulsa World. Retrieved 17 April 2023.
  9. ^ Breasette, Austin (30 October 2023). "OMRF scientist receives grant from Alzheimer's Association for research". KFOR. Retrieved 1 March 2024.
  10. ^ Monies, Paul (18 May 2003). "Oklahoma Business Scientist Working on Breast Cancer Tests". The Oklahoman. Retrieved 14 April 2023.
  11. ^ Jupe ER, Badgett AA, Neas BR, Craft MA, Mitchell DS, Resta R; et al. (2001). "Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility". Lancet. 357 (9268): 1588–9. doi:10.1016/s0140-6736(00)04747-4. PMID 11377649.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ^ Hardie, Alison (13 April 2006). "Hopes rise of cure for cancer as scientists reverse cell division". The Scotsman.
  13. ^ Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL | display-authors=etal (2006) The reversibility of mitotic exit in vertebrate cells. Nature 440 (7086):954-8. DOI:10.1038/nature04652 PMID: 16612388
  14. ^ "Hope in cancer battle". Birmingham Mail (Birmingham, UK). 13 April 2006.
  15. ^ Carter, Ray (22 March 2002). "Judge allows OMRF to sue drug maker". The Journal Record. Retrieved 14 April 2023.
  16. ^ Taylor FB, Carroll RC, Gerrard J, Esmon CT, Radcliffe RD (1981) Lysis of clots prepared from whole blood and plasma. Fed Proc 40 (7):2092-8. PMID: 7194803
  17. ^ Taylor FB, Chang A, Hinshaw LB, Esmon CT, Archer LT, Beller BK (1984) A model for thrombin protection against endotoxin. Thromb Res 36 (2):177-85. DOI:10.1016/0049-3848(84)90339-6 PMID: 6506035
  18. ^ "Researchers Seek Families With Lupus". The Oklahoman. 9 July 1996. Retrieved 10 April 2023.
  19. ^ Rasmussen A, Sevier S, Kelly JA, Glenn SB, Aberle T, Cooney CM | display-authors=etal (2011) The lupus family registry and repository. Rheumatology (Oxford) 50 (1):47-59. DOI:10.1093/rheumatology/keq302 PMID: 20864496
  20. ^ Koo, Malcom (18 July 2021). "Systemic Lupus Erythematosus Research: A Bibliometric Analysis over a 50-Year Period". Environmental Research and Public Heath. PMID 34281030. Retrieved 1 March 2024.

Thanks very much for looking over these ideas.Hl eikomala (talk) 18:11, 17 October 2024 (UTC) Hl eikomala (talk) 18:11, 17 October 2024 (UTC)[reply]

I agree that these changes are appropriately sourced and represent a significant improvement over the current article text. However, given the volume of changes I'd be grateful for a second opinion from another editor. Axad12 (talk) 05:09, 18 October 2024 (UTC)[reply]

Reply 21-NOV-2024

[edit]

Below you will see where proposals from your request have been quoted with reviewer decisions and feedback inserted underneath, either accepting, declining or otherwise commenting upon your proposal(s). Please read the enclosed notes within the proposal review section below for information on each request.

Edit request review 21-NOV-2024

OMRF conducts its research across five different divisions: Aging & Metabolism, Arthritis & Clinical Immunology, Cardiovascular Biology, Cell Cycle & Cancer Biology, and Genes & Human Disease
no Declined.[note 1]


In 2000, OMRF researchers created an inhibitor that, in vitro, stopped the enzyme thought to cause Alzheimer's disease. In 2007, OMRF researchers found evidence of a molecular mechanism that links an Alzheimer’s susceptibility gene called “E4” to the onset of the disease.
no Declined.[note 2]


In 2023, OMRF researchers began studying the connection between estrogen and Alzheimer’s in postmenopausal women.
no Declined.[note 3]


Please change the heading from “Alzheimer's and brain diseases” to “Aging & Metabolism.”
no Declined.[note 4]


In 2003, OMRF researchers developed a genetic test for assessing breast cancer risk in women. In 2006, OMRF researchers were able to reverse mitotic exit (cell division) in vertebrate cells.
no Declined.[note 5]


Please change the heading to “Cell Cycle & Cancer Biology”.
no Declined.[note 6]


In the 1980s, OMRF researchers conducted several studies on protein C and developed a treatment for sepsis which utilized activated protein C.
no Declined.[note 7]


In 1995, OMRF researchers established a national registry and data repository for studying the genetic causes of systemic lupus erythematosus.
 Approved.Cite error: There are <ref> tags on this page without content in them (see the help page).


In 2021, a study published in the International Journal of Environmental Research and Public Health found that over a 50-year period beginning in 1971, OMRF contributed the most publications on lupus in the United States.
no Declined.[note 8]


Please change the heading to “Genes & Human Disease”.
no Declined.[note 9]


___________

  1. ^ It's not clear what these division titles include. For example, the division titled "Aging" says nothing about what research is conducted (or what that entails) in the name of aging or aging related conditions.
  2. ^ These medical claims require peer-reviewed sourcing.
  3. ^ It's unclear what is meant by the phrase "began studying".
  4. ^ It's not clear how the new titles offer an improvement over their previous versions. Please clarify.
  5. ^ Only one peer-reviewed source was supplied with the request for these two claims, and the exact page number for that source has not been provided.
  6. ^ It's not clear how the new titles offer an improvement over their previous versions. Please clarify.
  7. ^ Two peer-reviewed sources were supplied with this claim, however, the page ranges given include content covering 16 pages.
  8. ^ The page numbers for the peer-reviewed sources were not provided.
  9. ^ It's not clear how the new titles offer an improvement over their previous versions. Please clarify.

Regards,  Spintendo  10:21, 21 November 2024 (UTC)[reply]

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