Talk:Neurobiological effects of physical exercise/Archive 1

This is an archive of past discussions about Neurobiological effects of physical exercise. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page.

Archive 1

Archive 2

Page feedback

Hi, page looks great but one thing i have noticed helps to clean up the page is if you organize your references by using

<ref name="arbitrary">full cite goes here</ref>, then if you want to cite the same article 
again, instead of retyping the source you can just type 
<ref name="arbitrary"></ref>

.

This way your reference section will not have several repeats of the same resource.

Other than that it looks great Psyc3330w12gp04BV (talk) 15:40, 2 March 2012 (UTC)

Merging the Runner's high article

Since every reference in the Runner's high article fails WP:MEDRS and the page contains mostly medical statements, this section is more of an FYI than a discussion about merging the article. I.e., I could justifiably (per that policy) reduce the whole article to a stub right now, but that's not a preferable solution IMO.

So, once I've completed the short-term effects subsection "Neurobiological effects of physical exercise#Effects on neurotransmitters, neuromodulators, and neuropeptides", I plan to go through with this merger; I expect to include a 1 paragraph section on the phenomenon under "Short-term effects", but I intend to keep the evidence related to its neuropharmacology contained in the section on neuro-transmitters/modulators/peptides (the previous link). Seppi333 (Insert 2¢ | Maintained) 23:08, 15 February 2015 (UTC)

GA review link

Talk:Neurobiological effects of physical exercise/GA1

– Seppi333 (Insert 2¢) 22:59, 27 July 2016 (UTC)

Mouse model of a runner's high

I've removed the following text from the article because this paper is a primary source and an animal study; biomedical statements need to be cited by references that satisfy the WP:MEDRS guideline. The other sources in the article on a runner's high/rower's high do not define the high as a state of anxiolysis, sedation, or pain relief, so this text was out of place in the anandamide section. Seppi333 (Insert 2¢) 02:09, 1 April 2016 (UTC)

In 2015, it was demonstrated in mice that certain features of a runner's high depend on cannabinoid receptors in mice. Pharmacological or genetic disruption of cannabinoid signaling prevents the analgesic and anxiolytic effect of running.^[1]

References

^ Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, and Gass P (2015). "A runner's high depends on cannabinoid receptors in mice". PNAS. 112 (42): 13105–13108. doi:10.1073/pnas.1514996112. PMID 26438875. Exercise is rewarding, and long-distance runners have described a runner's high as a sudden pleasant feeling of euphoria, anxiolysis, sedation, and analgesia. A popular belief has been that endogenous endorphins mediate these beneficial effects. However, running exercise increases blood levels of both β-endorphin (an opioid) and anandamide (an endocannabinoid). Using a combination of pharmacologic, molecular genetic, and behavioral studies in mice, we demonstrate that cannabinoid receptors mediate acute anxiolysis and analgesia after running. We show that anxiolysis depends on intact cannabinoid receptor 1 (CB1) receptors on forebrain GABAergic neurons and pain reduction on activation of peripheral CB1 and CB2 receptors. We thus demonstrate that the endocannabinoid system is crucial for two main aspects of a runner's high. Sedation, in contrast, was not influenced by cannabinoid or opioid receptor blockage, and euphoria cannot be studied in mouse models.

Feedback

@Looie496: I think I'm going to return to working on this article next week. I figured I'd seek your feedback on any general/specific topics that you think are worth adding/covering or if there's any existing content (in the Long-term effects or Short-term effects sections) that you think needs to be rewritten or expanded.

I still think both of those level 2 headers don't reflect their subsections, but I'm not sure how I'm going to reorganize that part of the article yet; MOS:MED#Sections isn't particularly helpful in unique cases like this article. So in the event you have any suggestions about the layout, I'd be happy to hear them. Seppi333 (Insert 2¢) 14:15, 4 December 2015 (UTC)

Nevermind, I think I've more or less decided on a layout now. Seppi333 (Insert 2¢) 10:08, 26 February 2016 (UTC)

I completely restructured these sections; I think the layout and topical coverage within these sections makes sense now. I'll probably resume working on this article soon since the rather awkward layout was offputting for me. Seppi333 (Insert 2¢) 20:55, 12 March 2019 (UTC)

Neurobiological effects of physical exercise#Effects on neural disorders

@Doc James: during the GA review, you mentioned that some of the content on clinical effects and the mechanisms that mediate exercise-induced effects on the brain should be covered separately. I've reorganized the article so that the effects on disorders are covered under a different section on that topic (linked in the header). The long-term effects section now only covers neurotrophic factor signaling mechanisms that affect brain structure/function as well as persistent exercise-induced effects on cognition and brain structure/function.
Is this what you had in mind? Seppi333 (Insert 2¢) 17:10, 26 February 2016 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 25 February 2020 and 2 May 2020. Further details are available on the course page. Student editor(s): Ccrabtree15.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 01:33, 18 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 14 August 2020 and 4 December 2020. Further details are available on the course page. Student editor(s): Pedro.torres26. Peer reviewers: David Torres Montalvo, Ivanaliztorresm.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 01:33, 18 January 2022 (UTC)

Potential source

Stumbled across this 2009 review which doesn't appear to be used here. There may be better sources in the article now but I figured I'd link it here in case there is anything worthwhile in it. http://www.annualreviews.org/doi/full/10.1146/annurev.psych.60.110707.163551 Sizeofint (talk) 17:20, 19 August 2016 (UTC)

On second glance it is more about the physiological effects of mental health so it may not be applicable here. Sizeofint (talk) 18:12, 19 August 2016 (UTC)

This page covers pretty much everything from the micro-scale molecular neurobiology of exercise and its impact on the brain and cognition to macro-scale exercise-induced neuroplasticity and the physiological and/or psychological effects of that neuroplasticity (e.g., the glutamate section covers research on the effect of exercise on cardiovascular disease from long-term changes in the rostral ventrolateral medulla; the short-term effects section covers the impact of exercise on the body's short-term response to psychological stress through long-term exercise-induced changes to the HPA axis). In a nutshell, this page isn't strictly confined to covering effects on the brain; it also covers effects on the body that either cause or are effects of exercise-induced effects on the brain. Anyway, I haven't read that review, but if there's something you think is worth including, feel free to quote an excerpt here and I'll look into adding it. Seppi333 (Insert 2¢) 22:48, 19 August 2016 (UTC)

Abbreviations

Why are there dotted lines under all the abbreviations in the article? Natureium (talk) 04:30, 12 December 2016 (UTC)

Place your mouse cursor over any of the abbreviated words which have a dotted line underneath. You'll see the expanded term in a tooltip. Seppi333 (Insert 2¢) 04:35, 12 December 2016 (UTC)

[runnershigh-1] Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, and Gass P (2015). "A runner's high depends on cannabinoid receptors in mice". PNAS. 112 (42): 13105–13108. doi:10.1073/pnas.1514996112. PMID 26438875. Exercise is rewarding, and long-distance runners have described a runner's high as a sudden pleasant feeling of euphoria, anxiolysis, sedation, and analgesia. A popular belief has been that endogenous endorphins mediate these beneficial effects. However, running exercise increases blood levels of both β-endorphin (an opioid) and anandamide (an endocannabinoid). Using a combination of pharmacologic, molecular genetic, and behavioral studies in mice, we demonstrate that cannabinoid receptors mediate acute anxiolysis and analgesia after running. We show that anxiolysis depends on intact cannabinoid receptor 1 (CB1) receptors on forebrain GABAergic neurons and pain reduction on activation of peripheral CB1 and CB2 receptors. We thus demonstrate that the endocannabinoid system is crucial for two main aspects of a runner's high. Sedation, in contrast, was not influenced by cannabinoid or opioid receptor blockage, and euphoria cannot be studied in mouse models.

[1]