Talk:Muscimol/Archive 1

Archive 1

source for ld50

here --89.138.125.236 16:24, 26 February 2007 (UTC)

Muscimol a dissociative?

Dissociation is a particular state of mind with recognizable characteristics. If muscimol produces this state, there should be at least one recorded case of it having done so. I can't find any such cases in any of the relevant literature. Even a review of somewhat unreliable "trip reports" fails to establish a single instance of dissociation produced by muscimol. Furthermore, the mode of action of muscimol would not lead one to believe that it is a dissociative drug. It shares nothing in common with known dissociative drugs. I removed the dissociative drugs template back in Dec. 2007, but it was promptly restored without any justification at all. Let's at least have this unsourced and dubious content stay off the page until someone can grace us with even a nominal rationale for its inclusion. deranged bulbasaur 01:48, 21 September 2008 (UTC)

"Lethal poisonings have occurred from A. muscaria and A. pantherina as well." Bullshit

Very annoying that people insist on reverting it back to calling it a dissociative. It is not mentioned on dissociative page and doesn't share characteristics of the classes listed (NMDA antagonists and k-opioid agonist). Nobody ever tries to claim substances with a similar pharmacology to muscimol as a dissociative. But for what ever reason psilocybin enthusiasts are set on calling it a dissociative or even a deliriantt. -Ssdfsdfldsjfh

References

• Camazine, Scott (1983). "Mushroom chemical defense: Food aversion learning induced by hallucinogenic toxin, muscimol". Journal of Chemical Ecology. 9 (11): 1473. doi:10.1007/BF00988513.
• Mitchel, D H (1980). "Amanita Mushroom Poisoning". Annual Review of Medicine. 31: 51–7. doi:10.1146/annurev.me.31.020180.000411. PMID 6772091.
• Michelot, D (2003). "Amanita muscaria: chemistry, biology, toxicology, and ethnomycology". Mycological Research. 107 (2): 131. doi:10.1017/S0953756203007305.

--Stone (talk) 14:45, 26 December 2010 (UTC)

Untitled

the molecule diagram is drawn incorrectly, pubchem and other sources draw muscimol with a double bonded oxygen not a single bonded OH group -- someone who takes care of these things should make a correction ASAP! —Preceding unsigned comment added by 24.61.45.83 (talk) 08:55, 28 November 2009 (UTC)

2-Pyridone

This is a isomere form of the molecule. If you move one hydrogen from the OH to the N, the double bond moves from the C=N to the C=O and this tautomerism is strongly depending on the solvent you use or if you have the crystalline form. The 2-Pyridone article might be a good example for it. --Stone (talk) 15:05, 26 December 2010 (UTC)

Page views

Leo1pard (talk) 17:34, 2 January 2018 (UTC)

Structure 8

Structure 8 in the synthesis is wrong, it should be a chloromethylisoxazole, not a dichloroacetylamidomethyl-isoxazole. You mixed up two different synthesis routes here. The Dichloroacetamide was an intermediate in another synthesis route by the same author. 2001:9E8:32E2:2300:DD0D:3CCA:CA9:3E59 (talk) 14:03, 26 February 2023 (UTC)

Toxicity

Article writes "Human deaths are rare, mainly occurring in young children, the elderly, or those with serious chronic illnesses."

But this is pointless since it obviously refers to mushroom poisoning, not poisoning with muscimol. The sentence implies that many people have experienced muscimol poisoning when in fact the number of people to ever have ingested pure muscimol will be quite low and no fatal case is presumably known.

Poisoning with mushrooms is complex and cannot be limited to muscimol action. In any case it should be discussed in the relevant mushroom articles, not here. 2001:9E8:32E2:2300:DD0D:3CCA:CA9:3E59 (talk) 14:15, 26 February 2023 (UTC)