Talk:Miricorilant
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Cyclohexane cis/trans isomerism
[edit]There is some confusion in the databases about whether the substituents on the cyclohexane are cis or trans. The original synthesis paper (doi:10.1016/j.bmcl.2012.10.074) discusses a bunch of related structures and notes that for the parent the trans isomer is the active one. They then disclose a synthesis that gives only that one, and discuss applying it to many analogs including miricoilant. However, in some of their data-tables, they draw the cis one instead. Some databases seem to have picked up the cis one. I updated our article to note that it is specifically trans and cited this paper. DMacks (talk) 05:58, 20 November 2024 (UTC)