Talk:Miles Vaughan Williams

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Pharmacology

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Singh

There have been some recent edits related to the contribution by Singh, but these contributions have been reversed (by others) as unreferenced. In case this occurs again, I though that I'd start a discussion here about the classification system. The Singh DPhil thesis referred to, according to the Oxford library catalogue is:

Singh, B. N. (Bramah N.)(1971) A study of the pharmacological actions of certain drugs and hormones with particular reference to cardiac muscle. x, 155 leaves : illustrations ; 27 cm

Key joint papers between Singh and Vaughan Williams were published in 1970,^[1]^[2] which appear to relate to amiodarone and other Class III compounds.

There is a broader article on antidysrhymic drugs by Vaughan-Williams in 1970,^[3] and there are a flurry of 1969 articles from Vaughan-Williams and others (but not Singh) discussing antidysrthymic drugs.^[4]^[5]^[6]^[7]

Vaughan-Williams had a clear interest, and published on, cardiac arrhythmias back from his time working with Burn in 1956,^[8] and developed important experimental techniques necessary for study such arrthymias in the 1950s.^[9]

So, to my eye, its not clear that Singh had a leading role, and that contributions of many others were equally important (and earlier), with Vaughan-Williams leading the line of enquiry. Klbrain (talk) 17:07, 20 July 2017 (UTC)[reply]

References

^ Singh, BN; Vaughan Williams, EM (August 1970). "A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474". British journal of pharmacology. 39 (4): 675–87. PMID 5485144.
^ Singh, BN; Vaughan Williams, EM (August 1970). "The effect of amiodarone, a new anti-anginal drug, on cardiac muscle". British journal of pharmacology. 39 (4): 657–67. PMID 5485142.
^ Vaughan Williams, EM (1970). "The experimental basis for the choice of an anti-arrhythmic drug". Advances in cardiology. 4: 275–89. PMID 4395423.
^ Papp, JG; Vaughan Williams, EM (October 1969). "The effect of bretylium on intracellular cardiac action potentials in relation to its anti-arrhythmic and local anaesthetic activity". British journal of pharmacology. 37 (2): 380–90. PMID 5348427.
^ Dohadwalla, AN; Freedberg, AS; Vaughan Williams, EM (June 1969). "The relevance of beta-receptor blockade to ouabain-induced cardiac arrhythmias". British journal of pharmacology. 36 (2): 257–67. PMID 5787666.
^ Vaughan Williams, EM; Dohadwalla, AN (10 May 1969). "Diarrhoea and intestinal fluid accumulation in uninfected rabbits cross perfused with blood from donor rabbits intra-intestinally infected with cholera". Nature. 222 (5193): 586–7. PMID 5786503.
^ Papp, JG; Vaughan Williams, EM (May 1969). "The effect of some catecholamine beta-receptor blocking compounds on the toxicity to the heart of ouabain". British journal of pharmacology. 36 (1): 178P–179P. PMID 5768092.
^ BURN, JH; VAUGHAN WILLIAMS, EM; WALKER, JM (28 February 1956). "The formation of acetylcholine in the heart; its effect on the systemic output and its importance for auricular fibrillation caused by aconitine". The Journal of physiology. 131 (2): 317–28. PMID 13320337.
^ VAUGHAN WILLIAMS, EM (9 May 1959). "Relation of extracellular to intracellular potential records from single cardiac muscle fibres". Nature. 183 (4671): 1341–2. PMID 13657117.

"You Don't Need a Gym"

Is that book really by the same guy as the article? It doesn't seem like it. Penguinmlle (talk) 17:17, 19 May 2022 (UTC)[reply]

Odd but true; I have a copy, and have talked to him about it. Interesting what one decides to do post-retirement! Klbrain (talk) 13:52, 8 February 2024 (UTC)[reply]

[1] Singh, BN; Vaughan Williams, EM (August 1970). "A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474". British journal of pharmacology. 39 (4): 675–87. PMID 5485144.

[2] Singh, BN; Vaughan Williams, EM (August 1970). "The effect of amiodarone, a new anti-anginal drug, on cardiac muscle". British journal of pharmacology. 39 (4): 657–67. PMID 5485142.

[3] Vaughan Williams, EM (1970). "The experimental basis for the choice of an anti-arrhythmic drug". Advances in cardiology. 4: 275–89. PMID 4395423.

[4] Papp, JG; Vaughan Williams, EM (October 1969). "The effect of bretylium on intracellular cardiac action potentials in relation to its anti-arrhythmic and local anaesthetic activity". British journal of pharmacology. 37 (2): 380–90. PMID 5348427.

[5] Dohadwalla, AN; Freedberg, AS; Vaughan Williams, EM (June 1969). "The relevance of beta-receptor blockade to ouabain-induced cardiac arrhythmias". British journal of pharmacology. 36 (2): 257–67. PMID 5787666.

[6] Vaughan Williams, EM; Dohadwalla, AN (10 May 1969). "Diarrhoea and intestinal fluid accumulation in uninfected rabbits cross perfused with blood from donor rabbits intra-intestinally infected with cholera". Nature. 222 (5193): 586–7. PMID 5786503.

[7] Papp, JG; Vaughan Williams, EM (May 1969). "The effect of some catecholamine beta-receptor blocking compounds on the toxicity to the heart of ouabain". British journal of pharmacology. 36 (1): 178P–179P. PMID 5768092.

[8] BURN, JH; VAUGHAN WILLIAMS, EM; WALKER, JM (28 February 1956). "The formation of acetylcholine in the heart; its effect on the systemic output and its importance for auricular fibrillation caused by aconitine". The Journal of physiology. 131 (2): 317–28. PMID 13320337.

[9] VAUGHAN WILLIAMS, EM (9 May 1959). "Relation of extracellular to intracellular potential records from single cardiac muscle fibres". Nature. 183 (4671): 1341–2. PMID 13657117.

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