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Lactulose/Mannitol Test for Gastrointestinal Permeability

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This is my first entry of any sort in Wikipedia. Hope this is done correctly.

May I suggest appending the well-known lactulose/mannitol test for gastrointestinal permeability and the L/M ratio. It is an old, but still clinically performed test. Plenty of references in Medline. I prefer to leave this task to experienced M.D. gastroenterologist.

DLW, PhD —Preceding unsigned comment added by Deewells (talk • contribs) 10:05, 18 December 2009 (UTC)[reply]

Replies at Deewells' talk page. Adrian J. Hunter(talk•contribs) 09:48, 19 December 2009 (UTC)[reply]

Mannitol in Plants

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Can someone (eg. a botanist) write something about mannitol in plants: mannitol dehydrogenase (MDH), it being produced by olives, its relevance in abiotic stress. THANKS massa 14:30, 26 February 2006 (UTC)[reply]

Permeability

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Earlier in the article it mentions being able to open the blood-brin barrier, but later on it says it is not able to cross biological membranes - is this an inconsistency, or does the blood-brain barrier not count as a membrane? --CharlesC 08:23, 13 July 2006 (UTC)[reply]

Or does it just "open" the blood-brain barrier without actually passing it? Sweetman 07:00, 8 August 2006 (UTC)[reply]


Here's what the article states and if you read it slowly and carefully, I feel you might just see what the author was stating. In the presence of all that other info, I see how the meaning is easily lost. Here:
Mannitol can also be used to open the blood-brain barrier by temporarily shrinking the tightly coupled endothelial cells that make up the barrier. This makes mannitol indispensable for delivering various drugs directly to the brain (e.g. in the treatment of Alzheimer's disease).
See? The Mannitol opens the barrier via the shrinkage allowing the other agents to passs through. Once the endothelial cells are free of the shrinking effect, they swell back to normal size. The mannitol is the agent that allows this but isn't the agent that is needed to pass thru. Hope that helps. Of course, I see now your question was back in August. Here's hoping you have this article marked on your watch page! Lisapollison 10:22, 11 December 2006 (UTC)[reply]

Scar Tissue Mention

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Mannitol is mentioned in Anthony Kiedis' book Scar Tissue. He states he use to watch his dad mix the laxitive Mannitol to cocaine to make it more profitable. -- MH 11 jan 07 —The preceding unsigned comment was added by 131.137.245.198 (talk) 13:49, 11 January 2007 (UTC).[reply]

Sugar?

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Does mannitol count as a sugar, even though it isn't a carbohydrate? Mauvila 20:02, 8 February 2007 (UTC)[reply]

Why isn't it a carbohydrate? Polyols or sugar alcohols are carbohydrates, i guess. —The preceding unsigned comment was added by 196.205.224.53 (talk) 16:16, 10 February 2007 (UTC).[reply]
I'm not sure...I define carbohydrates as how they originally were named, that is chemicals that have an empirical chemical formula of CH2O [C-(carbo-), H20 (hydr-)]. Mannitol is a reduced mannose, so it no longer adheres to the 1 C, 2 H, 1 O ratio of atoms. Mauvila 07:38, 14 April 2007 (UTC)[reply]
In the article as it stands now mannitol is referred to as a "Sugar alcohol". This is correct according to the definition of a sugar alcohol on its wikipedia page Echinoidea (talk) 15:04, 29 September 2008 (UTC)[reply]

Mannitol is both a carbohydrate and a sugar alcohol. —Preceding unsigned comment added by 124.170.66.124 (talk) 09:54, 7 April 2010 (UTC)[reply]

isolated from manna?

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so, i am confused if manna is actually a substance that exists; could someone be more specific, rather than a citation from 1880? —Preceding unsigned comment added by 68.222.197.74 (talk) 14:48, 7 October 2007 (UTC)[reply]

Ah sorry, at the time I added the reference the Manna page had a section since removed. Yes, the substance referred to does exist - the "Manna#Modern term" section used to say:
The term manna is also used in the modern context to refer to a secretion from various plants, including certain desert or semi-desert shrubs and especially the Ash Fraxinus ornus (manna or flowering ash) of Southern Europe. The material is produced by sap-sucking insects that secrete a honeydew like liquid, that when dried forms manna; it has a sweet taste. Eaten in large quantities, it is mildly laxative and has been used medicinally for that purpose.
It seems to have gone through some edit-warring since then, but I'll try and work out when and why that section was removed, and hopefully work out from that how to update the reference here to be useful. Hv 22:04, 9 October 2007 (UTC)[reply]
Ok, I've updated that paragraph - the explicit reference in Manna has moved to the section "#Later cultural references", and is no longer sufficiently clear and isolated to warrant linking directly, so I redrafted to try and ensure the relevant information is in. Hv 22:15, 9 October 2007 (UTC)[reply]

drug basics/general information

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Every drug indexed in wikipedia should contain at minimum (or be edited to have) the following information: Drug class, FDA approved indication/ also other uses, mechanism of action, contraindication, side effects/ adverse reactions, interactions with other drugs, route of administration/ and dosage, pregnancy category, percautions, brand names, how it's supplied and drug company, approximate cost.

Dr. ATL MD

There is an organized effort to do that at WP:PHARM. You're welcome to contribute. Deli nk (talk) 11:47, 20 December 2007 (UTC)[reply]

WikiProject Food and drink Tagging

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This article talk page was automatically added with {{WikiProject Food and drink}} banner as it falls under Category:Food or one of its subcategories. If you find this addition an error, Kindly undo the changes and update the inappropriate categories if needed. The bot was instructed to tagg these articles upon consenus from WikiProject Food and drink. You can find the related request for tagging here . Maximum and carefull attention was done to avoid any wrongly tagging any categories , but mistakes may happen... If you have concerns , please inform on the project talk page -- TinucherianBot (talk) 18:33, 3 July 2008 (UTC)[reply]

Toxicological info of the chemical...

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--222.64.222.67 (talk) 05:50, 31 January 2010 (UTC)[reply]

--222.64.222.67 (talk) 06:44, 31 January 2010 (UTC)[reply]

--222.64.222.67 (talk) 06:46, 31 January 2010 (UTC)[reply]

The chinese translation of the chemical is based on the following....

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--222.64.222.67 (talk) 07:37, 31 January 2010 (UTC)[reply]

Drugbox does not display all data

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Can someone familiar with the Drugbox syntax edit it so that the Drugbox displays all the information properly in Google Chrome and Microsoft Internet Explorer 8?. For example, the melting point, boiling point, water solubility, etc. are listed in the editing page but do not show in the article. THANKS 24.60.115.30 (talk) 11:27, 22 November 2010 (UTC)[reply]

What does mannitol have to do with antihypertensives?

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The bottom of the mannitol article has a table of antihypertensive (anti-high blood pressure) medications. What does that have to do with mannitol? — Preceding unsigned comment added by Mishka.medvezhonok (talk • contribs) 23:41, 2 March 2012 (UTC)[reply]

Mannitol open vs ring forms

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Hi,

I am very pleased to see that most sugars are specified to some extent in wikipedia in terms of chairs, boats and other ring structures in addition to open chain forms. This is completely absent in this article. I thought to add something myself, but have had no luck finding such information online. All structures I have encountered are open chain form, giving impression this is the only form, but no text specifying this is in fact so. Nothing is mentioned one way or other. Is there a sugar chemist in here who can contribute even a hint or reference so this can be appended?

Thanks in advance.

DLW PhD

Dear DLW PhD: Mannitol is not a sugar, its what is called a sugar alcohol. They do not spontaneously cyclize. --Smokefoot (talk) 12:47, 2 August 2013 (UTC)[reply]

Redirection of hexitol to mannitol

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Hi, To my knowledge, mannitol is not the only hexitol ! The page "hexitol" should not be redirected to this page concerning "mannitol". Here are exemples of other hexitols : iditol, sorbitol. — Preceding unsigned comment added by 84.99.26.99 (talk) 09:57, 1 March 2014 (UTC)[reply]

Laxative qualities and "baby laxative"

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The FDA gives odd, relative evidence of mannitol's laxative properties stating it causes diarrhea when consumed in 5 to 10x normal amounts eaten by adults (what's a normal level?) compared to sorbitol's 2 to 3x normal amounts even though the 1941 Mannitol and Sorbitol Study, p. 151. states sorbitol is laxative level on all test subjects is 50g and mannitol is 20g. The baby laxative seems to be a myth or comes from decades older incarnations of baby laxatives or misreading of the label. The current ones I find on the market have magnesium stearate or sodium alginate/magnesium alginate active ingredients with mannitol as an inactive ingredient. I found evidence that mannitol was used as a laxative solution for colonoscopy preparation before newer solutions were used. 24.241.69.99 (talk) 06:47, 15 October 2014 (UTC)[reply]

Can one buy Supplement Enzymes that break down Mannitol?

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And are they effective?

Mushrooms contain Mannitol and Trehalose. http://en.wikipedia.org/wiki/Trehalose ee1518 (talk) 10:30, 11 February 2015 (UTC)[reply]

Ref

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This needs a ref

"===Illicit drugs=== Mannitol is sometimes used as an adulterant or cutting agent for heroin, methamphetamines, cocaine, or other illicit drugs. In popular culture, when it is used in this manner, it is often referred to as baby laxative. An interview on the History Channel show Gangland showed a man claiming to be the chief methamphetamine "cooker" for the Pagans MC in Philadelphia, who stated that he used mannitol, a "baby laxative", as a "cut" for methamphetamine. He stated that in his hands the drug began as a purple color, and became first dark pink, then light pink, finally white as successive adulterations were done with mannitol. In the interview he stated that people snorting a line of the powder would need to go to the bathroom as a result of using it. He said that they incorrectly believed that this was the result of the potency of the drug, but it was actually caused by the added mannitol."

Doc James (talk · contribs · email) 06:01, 2 August 2016 (UTC)[reply]

Mention of ciguatera fish poisoning treatment removed

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The article about ciguatera states with citations that mannital is no longer recommended as a treatment for ciguatera poisoning. –droll [chat] 05:19, 7 August 2016 (UTC)[reply]

Drug Box to Chem Box conversion

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TerpeneOtto (talk) 23:45, 8 December 2016 (UTC) This page needs to be converted from a drug box to a chem box. Chem box provide more physical data about the substance and has space for the information provided. I am going to list the magnetic susceptibility here for future use in the properties portion. | MagSus = -111.20·10−6 cm3/mol . just insert into chem box when someone gets around to changing the formatting.[reply]

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Manicol Redirection

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Searching "Manicol" redirects to this article but manicol appears to be something else, "A eudesmane-type sesquiterpene acid with an aromatic A-ring isolated from a Guyanan tree Dulacia guianensis", or "Manicol, isolated from and for which structure was previously proposed, was shown to be the sesquiterpenoid hydroxytropolone ." Hoping for clarification. 71.80.252.179 (talk) 05:40, 8 July 2024 (UTC)[reply]

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