Talk:MMP3

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Removed a part of the Structure section

I removed the last part of the last paragraph in the Structure section, which read "In addition to these basic domains, the family of MMPs evolved into different subgroups by incorporating and/or deleting structural and functional domains. For example, MMP-2 and MMP-9, also known as gelatinases, incorporated the three repeats homologous to the type-II module of fibronectin into the catalytic domain that has been shown to be involved in binding to denatured collagen or gelatin. This domain, known as the gelatin binding domain or fibronectin type-II-like domain, is unique to the gelatinases, and so these enzymes are regarded as a separate subgroup among members of the MMP family. Incorporation of a hydrophobic stretch of approximately 25 amino acids, representing a putative transmembrane domain at the carboxy terminus and recognition motif (RXKR) for furin-like convertases at the end of the propeptide domain, is a characteristic of the membrane-type MMPs (MT-MMPs) except MT4-MMP (vide infra). MMP-11 also contains this furin recognition motif and, similar to the MT-MMPs, it is processed into the active form intracellularly. Additional insertion to the three basic MMP domains also includes a proline-rich 54 amino acid insertion in MMP-9 with sequence similarity to the α2 chain of collagen V. Finally, MMP-7 lacks the hemopexin-like domain and represents the smallest member of the MMP family."

I believe that this information is not very relevant to the article on MMP-3 and should instead be mentioned in an article for all MMPs. I have saved this paragraph (along with its citation) in my Sandbox if anyone believes it should be put back.

Valerieap (talk) 01:45, 1 March 2016 (UTC)Valerieap[reply]