Talk:Lythranidine

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	This article was accepted on 16 November 2012 by reviewer MatthewVanitas (talk · contribs).

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[Untitled]

Inaccurate Nitrone cycloaddition: an approach to the cyclophane alkaloid (±)-lythranidine. William Carruthers , Peter Coggins and John B. Weston J. Chem. Soc., Perkin Trans. 1, 1991, 611-616 does not synthesise natural product. They make C7 epimer.

Shortest racemic synthesis is 17 steps http://pubs.rsc.org/en/Content/ArticleLanding/1980/P1/P19800001066#!divAbstract, Shortest enantioselective is 15 Furstner et al http://onlinelibrary.wiley.com/doi/10.1002/anie.201402550/epdf.

"Lythranidine is classified as an alkaloid and it contains a piperidine group that defines the synthesis of the structure via nitrone cycloaddition." is not true see piperidine ring reductive cyclisation aza-michael type reactions as used by furstner and others for the formation of the piperidine ring.

All chemical synthesis is done in vitro.

Describing the synthesis is unnecessary as the reference is present and this section glosses over it anyway. Author misses the earlier work that describes the transformation of commercial starting material to the intermediates presented in http://pubs.rsc.org/en/Content/ArticleLanding/1980/P1/P19800001066#!divAbstract.

Bendysaur (talk) 00:48, 15 March 2015 (UTC)[reply]