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When reading the Wikipedia article on Lymphoid leukemia, our group thought it did a very good job of being straight to the point. Also, when reading the article, we thought it did a good job of not being opinionated. What impressed us about the article was how it had a bunch links to other Wikipedia articles. We found this impressive because if someone is unclear about certain information, then they can always check one of the link articles for more detail. The changes that we would make to the article is add the symptoms of the cancer. Another change that we would make to the article is place Flow Cytometry under a subheading because there is not a lot of information about this. Another change that our group would make is add pictures to the article because it can give people a better understanding about Lymphoid leukemia. The changes that our group mentioned would be an improvement to the article because it would provide more overall detail about the cancer. Also, adding pictures would be an improvement for the article because it can help people who are more visual learners have a better understand about this cancer. The three most important things that our group could do to improve the article is take out information that is not cited, add pictures, and update the information on Flow Cytometry because the current information is over ten years old.   (Kuiperal (talk) 00:21, 21 November 2016 (UTC))[reply]

Here are the contributions that I plan to add to this article along with its sources.

NK (Natural Killer) Cell Leukemia

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Aggressive NK-cell leukemia (ANKL) is a lymphoid leukemia that is a deficiency NK cells. Not very much is known about this disease due to its rarity, but it is highly aggressive. Most patients will die within 2 years. [1]

Diagnosis

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The requirements for diagnosing ANKL are as follows[2]:

  1. Immature-looking NK cells
  2. Certain immunophenotypes[3]
  3. Germline configuration genes: TCR-β and IgH
  4. Restricted cytotoxicity

Treatment and Therapy

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There currently is no specific treatment that works for ANKL. Most patients will die 6 months after diagnosis. [4]

Flow Cytometry

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Flow cytometry is a diagnostic tool in order to count/visualize the amount of lymphatic cells in the body. T cells, B cells and NK cells are nearly impossible to distinguish under a microscope, therefore one must use a flow cytometer to distinguish them. [5]

Therapy

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NK Cell Therapy

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Natural killer (NK) cell therapy is used in pediatrics for children with relapsed lymphoid leukemia. These patients normally have a resistance to chemotherapy, therefore, in order to continue on, must receive some kind of therapy. In some cases, NK cell therapy is a choice. [6]

NK cells are known for their ability to eradicate tumor cells without any prior sensitization to them. [7] One problem when using NK cells in order to fight off lymphoid leukemia is the fact that it is hard to amount enough of them to be effective. [8] One can receive donations of NK cells from parents or relatives through bone marrow transplants. There are also the issues of cost, purity and safety. [9] Unfortunately,there is always the possibility of Graft vs host disease while transplanting bone marrow.

NK cell therapy is a possible treatment for many different cancers such as Malignant glioma. [10] CharlotteHayden (talk) 17:43, 11 October 2016 (UTC)[reply]

References

  1. ^ Suzuki, R., Suzumiya, J., Yamaguchi, M., Nakamura, S., Kameoka, J., Kojima, H., . . . Oshimi, K. (2009). Prognostic factors for mature natural killer (NK) cell neoplasms: Aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type. Annals of Oncology, 21(5), 1032-1040. doi:10.1093/annonc/mdp418
  2. ^ Oshimi, K. (2003). Leukemia and lymphoma of natural killer lineage cells. International Journal of Hematology, 78(1), 18-23. doi:10.1007/bf02983235
  3. ^ Landay, A. L., & Muirhead, K. A. (1989). Procedural guidelines for performing immunophenotyping by flow cytometry. Clinical Immunology and Immunopathology, 52(1), 48-60. doi:10.1016/0090-1229(89)90192-x
  4. ^ Suzuki, R., Suzumiya, J., Nakamura, S., Aoki, S., Notoya, A., Ozaki, S., . . . Oshimi, K. (2004). Aggressive natural killer-cell leukemia revisited: Large granular lymphocyte leukemia of cytotoxic NK cells. Leukemia, 18(4), 763-770. doi:10.1038/sj.leu.2403262
  5. ^ Wilkinson, M. G. (2015). Flow cytometry in microbiology: Technology and applications.
  6. ^ Rubnitz, J. E., Inaba, H., Kang, G., & Gan, K. (08/01/2015). Pediatric blood & cancer: Natural killer cell therapy in children with relapsed leukemia John Wiley & Sons Inc. doi:10.1002/pbc.25555
  7. ^ Sakamoto, N., Ishikawa, T., Kokura, S., Okayama, T., Oka, K., Ideno, M., ...Yoshikawa, T. (2015). Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer. Journal of Translational Medicine, 13, 277. Retrieved from http://ezproxy.msu.edu.proxy2.cl.msu.edu/login?url=http://go.galegroup.com.proxy2.cl.msu.edu/ps/i.do?p=HRCA&sw=w&u=msu_main&v=2.1&it=r&id=GALE%7CA426490199&sid=summon&asid=7cbddd9a08c329d9f8f4003d692477cb
  8. ^ Sakamoto, N., Ishikawa, T., Kokura, S., Okayama, T., Oka, K., Ideno, M., ...Yoshikawa, T. (2015). Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer. Journal of Translational Medicine, 13, 277. Retrieved from http://ezproxy.msu.edu.proxy2.cl.msu.edu/login?url=http://go.galegroup.com.proxy2.cl.msu.edu/ps/i.do?p=HRCA&sw=w&u=msu_main&v=2.1&it=r&id=GALE%7CA426490199&sid=summon&asid=7cbddd9a08c329d9f8f4003d692477cb
  9. ^ Bachanova, V., & Miller, J. S. (2014). Critical reviews in oncogenesis: NK cells in therapy of cancer CRC Press. doi:10.1615/CritRevOncog.2014011091
  10. ^ Henry Ogbomo, Jindrich Cinatl Jr, Christopher H. Mody, Peter A. Forsyth, Immunotherapy in gliomas: limitations and potential of natural killer (NK) cell therapy, Trends in Molecular Medicine, Volume 17, Issue 8, August 2011, Pages 433-441, ISSN 1471-4914, http://dx.doi.org/10.1016/j.molmed.2011.03.004. (http://www.sciencedirect.com/science/article/pii/S1471491411000529)

Replace "Lymphoid leukemia" by "Lymphoid Neoplasm"

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In the WHO classification (which is abundantly cited in this article), the classification in "Leukemia" has disappeared, replaced by "Lymphoid neoplasm" (and Myeloid neoplasm) Linuxo (talk) 12:30, 3 June 2018 (UTC)[reply]

Which source we looking at? Doc James (talk · contribs · email) 13:14, 8 August 2018 (UTC)[reply]
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