Talk:Lofexidine

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Lofexidine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Lofexidine Website

The website for this drug is located at http://www.lofexidine.co.uk . I may try expanding this article, but it will be my first edit aside from talk pages. I don't really know the ins and outs of wikipedia at all yet, so it'd be much better if someone else did it. The website doesn't have all that much information, but it's definitely got a lot more then wikipedia does. Tainted42 06:31, 9 October 2007 (UTC)[reply]

Link is currently dead.―Biochemistry🙴❤ 00:01, 17 May 2018 (UTC)[reply]

Clinically Equivalent?

From what I understand, lofexidine is not clinically equivalent to methadone as purported and the fact that one is commonly used at higher doses than the other is completely meaningless unless were going to discuss the pharmacological mechanism by which they both eliminate the some of the same symptoms (certain withdrawal symptoms). They're not equivalent because methadone provides a whole set of effects that lofexidine does not and they're not even clinically equivalent with regards to withdrawal symptom relief because lofex. does not allievate all the symptoms nor does it provide complete relief. I would simply say that it is a useful aid for mitigating some of the unwanted effects of opioid withdrawal due to its antagonism of alpha-2 andrenergic receptors. -Zach —Preceding unsigned comment added by 66.191.120.105 (talk) 02:36, 18 August 2008 (UTC)[reply]

Inaccuracies?

Agree with the previous post on clinical equivalence. Additionally, the note on naltrexone being used to *attenuate* withdrawal symptoms is questionable at best, and might lead one to [wrongly] conclude that naltrexone can be used to provide relief from withdrawal in one actively dependent on opioids. Naltrexone is well-known to exacerbate (and indeed, precipitate) withdrawal in such individuals. —Preceding unsigned comment added by 12.40.227.4 (talk) 15:43, 13 August 2009 (UTC)[reply]

Racemic mixture or pure enantiomer?

Is this compound a racemate [50% (R)-stereoisomer + 50% (S)-stereoisomer] or the pure (R)-stereoisomer or the pure (S)-stereoisomer? Stereoisomers regulary have a different pharmacology and different pharmacokinetics [E. J. Ariëns: Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology, European Journal of Clinical Pharmacology 26 (1984) 663-668].--Jü (talk) 20:22, 14 August 2009 (UTC)[reply]

External links modified

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