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Autism

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In the wikipedia autism article, I read that

  • Maternal nutrition and inflammation during preconception and pregnancy influences fetal neurodevelopment. Intrauterine growth restriction is associated with ASD, in both term and preterm infants. Maternal inflammatory and autoimmune diseases may damage fetal tissues, aggravating a genetic problem or damaging the nervous system.

and

  • There is evidence that gut–brain axis abnormalities may be involved. A 2015 review proposed that immune dysregulation, gastrointestinal inflammation, malfunction of the autonomic nervous system, gut flora alterations, and food metabolites may cause brain neuroinflammation and dysfunction. A 2016 review concludes that enteric nervous system abnormalities might play a role in neurological disorders such as autism. Neural connections and the immune system are a pathway that may allow diseases originated in the intestine to spread to the brain.

I propose, therefore, that autism be added to the list under the "non-autoimmune" heading, to demonstrate that it at least being considered as a possible autoimmune disease. Objections? Piedmont (talk) 11:19, 2 May 2021 (UTC)[reply]

I have added this change, as proposed. Piedmont (talk) 11:14, 14 May 2021 (UTC)[reply]

List of qualifiers - updated

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My apologies for not focusing on this but I am about to spend some time, so if you are interested in this page, please post here and I will try to accommodate any comments and suggestions.

First, I would like to come up with a way to characterize these diseases better. Here are the issues:

1. We need a way to decide whether a disease is "officially" autoimmune. The Rose Bona criteria are published and the original list was part of the article on Autoimmune Disease - when the list was moved, the reference to Rose Bona was not. I will add it back as appropriate. However, the Rose Bona criteria, a modification of the Witebsky postulates (which I will also notate) are so stringent that only a handful of diseases qualify (autoimmune thyroiditis and myasthenia gravis are 2 I know of). The rest are implicated by the presence of antibodies (strong evidence of autoimmune etiology) or simply circumstantial evidence (no other etiology, predominantly affect women, follow a pattern of flare-ups and remissions). In many cases, it is a judgment call where a disease fits.

2. We need a way to characterize diseases that are caused by autoimmune processes only some of the time. A patient who has their pancreas removed due to cancer will suffer from type 1 diabetes, but not from an autoimmune process. In other cases, infections or genetics can cause disease in one individual that is caused by autoimmune processes in another. In genetics, we use the term "penetrance" to describe the rate at which people with the gene exhibit the phenotype we expect. In autoimmunity, we need a term to describe the percentage of persons suffering from a disease that have the disease due to an autoimmune process.

I would love feedback on both of these issues.

Also please advise on my Wikipedia etiquette, as I am still not well versed in it.


Second, as I had posted here earlier, I will be changing the table at least to remove the flags referring to the prior version of the table:

A "Accepted" in prior version of this table S "Suspected" in the prior version of this table N Not listed in prior version of this table Y Listed in the prior version of this table with "Accepted/Suspected" left blank

The prior version of the table is over 3 years old and if someone wants to see it they can go to the history.

I also propose to reuse "N" to indicate "New research" that changes the status of a condition. For example, Chronic Fatigue Syndrome has received some new credibility from the NIH. I propose that any disease that has a footnote pointing to research published in the past year that changes the "Level of Acceptance" should be flagged with an N and a footnote. I propose to adhere to a "no footnote, no N" rule. This will help ensure all changes are supported with references. I will review on a regular basis and remove "N" values that are a year or so old to keep the meaning accurate.


Aaron Abend (talk) 12:37, 26 December 2019 (UTC)[reply]

2602:306:35FA:B090:F9B8:34:BF0A:72E2 (talk) 03:57, 10 July 2017 (UTC) Interstitial Cystitis is listed as Kidney Disease. It is a Urinary Bladder Disease (as you'll see when you click its related link(s)). July 9, 2017 2602:306:35FA:B090:F9B8:34:BF0A:72E2 (talk) 03:57, 10 July 2017 (UTC)[reply]

Thanks for the info - I will change that! Aaron Abend (talk) 12:37, 26 December 2019 (UTC)[reply]

A further issue is the qualifiers list's "C" designation, "given to diseases that are classified by Rose and Bona as having 'circumstantial' evidence of autoimmune etiology. [These] are, therefore, actual autoimmune diseases."

Actual diseases, yes. Actually autoimmune, not necessarily, for the evidence of that is, per Messrs. Rose and Bona, merely circumstantial. Mucketymuck (talk) 04:11, 3 October 2020 (UTC) 04:09, 3 October 2020 (UTC)[reply]

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Good Bot. GangofOne (talk) 19:17, 23 June 2017 (UTC)[reply]

Stanford says "Narcolepsy is an autoimmune disease."

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(at least since the H1N1 flu vaccine triggered Narcolepsy phenomenon) Source: http://med.stanford.edu/narcolepsy.html May I change it? — Preceding unsigned comment added by 2605:A000:D020:C900:4990:F141:538A:DE59 (talk) 14:16, 6 September 2017 (UTC)[reply]

Who is Rose Bona and what are her qualifications?

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"C A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. This designation is given to diseases that are classified by Rose Bona as having "circumstantial" evidence of autoimmune etiology. Diseases in this list with a "C" are, therefore, actual autoimmune diseases, rather than comorbid symptoms, which appear after this list."

So who is Rose Bona? Her name isn't a link to the article on her. A google search on her turned up nothing.

And isn't the Wikipedia rule that evidence must have been prior published in an authoritative journal, archive, book, or periodical. That is, Wikipedia isn't supposed to publish original research.

Anyways, so who is Rose Bona? Thanks.

50.71.169.56 (talk) 09:48, 27 September 2017 (UTC)[reply]

I did some searching and found a 1993 paper by Noel R. Rose and Constantin Bona. (Link) I'm pretty confused by the table and the descriptors listed. How was this table originally compiled? Natureium (talk) 22:49, 25 December 2017 (UTC)[reply]
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Autoimmune autonomic ganglionopathy needs to be added to this list, and written by a medical professional.

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Hello everybody - Would a medical professional please add to this list and describe Autoimmune autonomic ganglionopathy (AAG)? I have added a link to its Wikipedia article under the "See also" section because I am not a medical professional and I am not qualified to write about this. You may help someone who has this rare disease. Thank you. Entertainment Buff 16:23, 10 January 2019 (UTC)

Eczema

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This edit changes the table entry for eczema to claim it is an autoimmune disease. The edit does not provide a citation. The page on eczema does not say it is or is not autoimmune. Either way, if it is autoimmune, it should not be in the table in the section Non-autoimmune. I am going to revert the linked edit. Kimen8 (talk) 00:17, 15 October 2023 (UTC)[reply]

Hi, I do not know why you revered that edit. The citations you restored are completely unrelated to if eczema is or is not an autoimmune, and the pages on Eczema do indicate that it can be an autoimmune disease (such as the Terminology section in the article you link).
I'm reverting your edit, I don't have a medical textbook handy, but I think it is better to lack citations than have incorrect citations. BenErroneous (talk) 03:46, 8 November 2023 (UTC)[reply]
Not sure what the proper acceptance level would be, it comes more down to what the person you are asking thinks is an acceptable meaning of Eczema than any dispute over the science. Also there is the question if the most technical usage of the word Eczema would be wanted rather than it common usage in medical contexts BenErroneous (talk) 04:46, 8 November 2023 (UTC)[reply]
The "Non-autoimmune table" is for diseases that at this time, there is not sufficient evidence—direct, indirect, or circumstantial—to indicate that these diseases are caused by autoimmunity. You're right that the existing sources don't say it is not autoimmune, but they don't say it isn't either, and hence why it is in the table "Non-autoimmune" with the explanation that is written above the table.
I wrote the 2 reasons for my revert already: (1) your changing from the statement "eczema may or may not be autoimmune" to "eczema is autoimmune" requires a source to back it up; (2) even if you do provide a source saying it is autoimmune, the table currently housing eczema is a table of "Non-autoimmune", and if you're able to show that it is autoimmune, then it should be moved into the "Autoimmune" table in the article. Kimen8 (talk) 10:51, 8 November 2023 (UTC)[reply]
the page on does state it can be an autoimmune disease, and did at the time of your revert BenErroneous (talk) 13:29, 8 November 2023 (UTC)[reply]
the issue with a source is that eczema isn't really a well defined thing in medical settings, but rather a lay term that is still in use. Even Atopic Dermatitis, a much more specific form, has issues of definition, with a lack of consensus of what it is.
Like here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228598/ is a source that mentions many of the issues with Eczema and Atopic Dermatitis definition. But if you look you see Eczema is not a popular term for use in medical literature, despite being a common diagnosis in large datasets BenErroneous (talk) 14:04, 8 November 2023 (UTC)[reply]

Outdated sources about narcolepsy

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All paper cited were published before 2010, with the earliest dated back to 2001, over 20 years ago. More recent research, especially those that focuses on increased cases associated with the 2009 flu pandemic and the use of Pandemrix vaccine during this period, actually supports the idea that one form of the disease, narcolepsy type 1 (NT1, also known as narcolepsy with cataplexy), may be an autoimmune disorder. There is still no evidence showing that nacrolepsy type 2 (NT2, also know as narcolepsy without cataplexy) is an autoimmune disorder. Whether this can elevate the level of acceptance to "possible" is not what me as a non-professional can determine. Meanwhile, I will add an update inline template. Conflict of interest: I am an NT1 patient.

Here are some recent papers about the possibility of NT1 as autoimmune disorder (some are paywalled):

Giannoccaro, M. P. et al. (2021) ‘Reviewing the Clinical Implications of Treating Narcolepsy as an Autoimmune Disorder’, Nature and Science of Sleep, 13, pp. 557–577. doi: 10.2147/NSS.S275931.

Kornum, B.R. (2021) ‘Narcolepsy type I as an autoimmune disorder’, The Human Hypothalamus - Neuroendocrine Disorders, pp. 161–172. doi:10.1016/b978-0-12-820683-6.00012-9.

Liblau, R.S. et al. (2023) ‘The immunopathogenesis of narcolepsy type 1’, Nature Reviews Immunology, 24(1), pp. 33–48. doi:10.1038/s41577-023-00902-9. Kaileeslight (talk) 07:43, 11 June 2024 (UTC)[reply]

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