Talk:Liothyronine

Cytomel should redirect here or have a See also section for here. Merge perhaps though since both are substubs... Schissel | Sound the Note! 13:25, 24 September 2006 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2019 and 12 December 2019. Further details are available on the course page. Student editor(s): Hayleysmitty18. Peer reviewers: Kelleytw.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 02:38, 17 January 2022 (UTC)

Side effects

Aren't all side effects, except possible allergic reactions, caused by too high doses? Since the drug is the same to the body as its own T3, side effects shouldn't happen. Aeluwas (talk) 16:13, 8 December 2007 (UTC)

Wrong structure

The stereoisomer shown is R, while the name is presented as S. Can someone change this? — Preceding unsigned comment added by 50.193.173.17 (talk) 13:36, 19 February 2014 (UTC)

Chemical Hormones are Not the Same as Natural Hormones

Aren't all side effects, except possible allergic reactions, caused by too high doses? Since the drug is the same to the body as its own T3, side effects shouldn't happen. Aeluwas (talk) 16:13, 8 December 2007 (UTC)

I don't believe that "all side effects" are caused by "too high doses." Say a drug is developed to cure disease "A"; it may indeed do what it is designed for, curing "A" - but in the process an unintended side effect may be that the drug damages other tissues not related to the "A" disease.

Chemical thyroid hormones [this & others] are NOT the same as the hormones our bodies naturally produce. The closest to our own is a desiccated thyroid hormone; either bovine or porcine.

Whomever is listing drugs on Wikipedia used to treat Thyroid disease need to make clear in the "drug" description if it is a chemical hormone or "natural drug/hormone". While the mainstream "western" medicine continues to ignore and dismiss the use of NATURAL desiccated thyroid hormones to treat thyroid disease; natural hormones may be the only treatment some patients can tolerate and have success with. Nearly every medical and pharmaceutical industry affiliated organization - U.S.A. & some international organizations do not advise patients that there are natural hormones available. That's just one source, there are more... — Preceding unsigned comment added by 65.34.13.13 (talk) 23:41, 12 September 2014 (UTC)

References

Half-life given inconsistently in two different places.

In the Drugbox, under the heading Pharmacokinetic data, the value of the half-life is given as 2.5 days. The section Disadvantages in thyroid hormone replacement has the sentence "It also has a short half-life of 1.5 hours requiring frequent dosing throughout the day." Something is wrong here. I do not have access to the reference given for the sentence, so that I can verify it. A quick Google search provided a range values of the half-life of Liothyronine of from 0.75 days to 2.5 days. Also, the half-life seems to be different depending on what patient condition it is being used for; See https://online.epocrates.com/u/10a568/liothyronine, for example, where is gives "Excretion: urine primarily; Half-life: 1 day (euthyroid), 0.6 day (hyperthyroid), 1.4 days (hypothyroid)" Edward E Fairchild (talk) 11:43, 20 March 2015 (UTC)

Incorrect statement

This statement from the article is completely wrong: "The dose of liothyronine for hypothyroidism is a lower amount than levothyroxine due it being a higher concentrated synthetic medication.[1]".

Liothyronine has a lower dose than levothyroxine because liothyronine is T3 whereas levothyroxine is T4, and T3 is about 4 times potent as T4. It isn't that liothyronine is "more concentrated", it's a different substance. Reference [1] from the article states this correctly. Pls2000 (talk) 07:11, 22 January 2020 (UTC)