Talk:Levorphanol
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FYI, the article on Levorphanol refers to DXM being an opioid, but this is not the case. This is a common misunderstanding.
You may check the medical research and literature for more information, but basically you could describe it simply as being something of an analogue of it; the molecular structure is similar, but not identical. Even your own DXM page contains the correct information, thus this should be an easy fix :-)
-- Ville Hakomäki, EEG Embedded R&D Ltd. Senior Research Coordinator of Neurosciences
- My limited input of this is that DXM (dextromethorphan) is a r. isomer of levorphanol. The molecule
has been tweaked by the process of rotation. Brilliant pharmacology once again. The effects (and all other dynamics of DXM, such as dependency) are quite different. DXM seems to have some mild opiate effects as described by knowledgeable users, but the main actions are actual hallucinitory effects, a strange to explain sensation of 'feeling small', along with pin prick effects inward and outward. Its quite amazing how a molecule can be 'tweaked' by simple process, and the effects are markedly different. Experementing with DXM is probably ok, in my limited view, but regular use is NOT indicated or recommended. Some relief of opiate withdrawal has been seen with DXM use. Tells me in the very complex realm of psychobiology (regarding mu, kappa, sigma, & delta opiate receptors) that the metabolism of DXM seems to reach some of these possibly. **One last note, Levorphanol (Roche) has been shown to be quite a useful, safe, and long-lasting analgesic for moderate to severe pain, and should be used much more frequently implace of other less useful substances (by prescribing physicians).
Greg King Rubicon Research Nutrition Science gkingxx@yahoo.com —Preceding unsigned comment added by 69.171.161.168 (talk) 06:00, 4 October 2009 (UTC)
This article has problems-- it is internally inconsistent. Levorphanol cannot be a pure mu-agonist (first sentence) while simultaneously having activity at kappa, sigma and delta receptors (first sentence of 3rd paragraph). Furthermore, the chemical structure (text) does not reflect the chiral center that makes *levo*rphanol. I am sure there are other issues if you dig into it. I would fix it myself but don't have the time right now. —Preceding unsigned comment added by Eesnyder (talk • contribs) 13:12, 28 January 2010 (UTC)