Talk:Isoxazoline
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Safety of Isoxazoline drugs for dogs is very questionnable
[edit]Neurological side effect for Dogs is much more common than vet drug manufacturers claim in product labels.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738705/ 2020 Nov.
A veterinarian and pet owner survey (Project Jake) examined the use and safety of isoxazoline parasiticides given to dogs.
58% (1594) had been treated with some parasiticide for flea control, and of those that received a parasiticide, the majority, or 83% (1,325), received an isooxazoline. When any flea treatment was given, AE were reported for 66.6% of respondents, with no apparent AE noted for 36.1%.
Survey responders did not indicate the Recovery Status from neurological effects. However, several isolated reports (private communications with the authors of which 3 are veterinarians have indicated extended long‐term neurologic signs with InComplete amelioration).
With respect to pet age, serious AE showed death reported in about 60% of dogs older than 5 years with seizures in more than 50% of dogs older than 5 years.
The most serious AE as stated in the EMA cumulative reports were observed at 0–24 hr after the first dose, and then again after the second and third doses.
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Are there studies of safety for humans?
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FDA is not very concerned, so perhaps most side-effects go away without permanent toxid effects for brain?
"Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products"