Talk:Interleukin 6

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Stub still?

Does this article still really qualify for stub status? --Selket 06:47, 22 January 2007 (UTC)[reply]

Looks like it has more info than a stub! Removed the tag for you. Ciar 17:28, 22 January 2007 (UTC)[reply]

It looks like there are many differences between the english and german wiki-website of IL-6. also in some points they do not match due to some contradictions. — Preceding unsigned comment added by 212.197.158.151 (talk) 14:47, 13 September 2016 (UTC)[reply]

Waldenstrom

people with waldenstrom have elevated il-6 and that makes elevated fibrinogen. So IL-6 must be secreted by these lymphoplasmic cells in waldenstrom. find a hematologist to confirm this. —The preceding unsigned comment was added by 207.151.255.15 (talk) 18:58, 16 February 2007 (UTC).[reply]

IL6

Inhibition of transsignaling soluble IL6R by GP130: doi:10.1182/blood-2007-07-102137 JFW | T@lk 19:19, 28 January 2008 (UTC)[reply]

Diabetes

In addition to other things IL6 is strongly associated with diabetes and its adverse effects on the macrovascular system.

Obscure text from Role in disease

This text removed : "Said et al. showed that Il-6 causes an IL-10-dependent inhibition of CD4 T-cell expansion and function by up-regulating PD-1 levels on monocytes which leads to IL-10 production by monocytes after binding of PD-1by PD-L.^[1]" as it's not clear which diseases it relates to. Suggest clarify before moving back. - Rod57 (talk) 23:09, 16 November 2011 (UTC)[reply]

References

^ Elias A. Said et al. 2009, PD-1 Induced IL10 Production by Monocytes Impairs T-cell Activation in a Reversible Fashion. Nature Medicine. 2010; 452-9.

Interleukin-6 or interleukin 6 ?

The title of the article is Interleukin 6 without the hyphen, but the first paragraph writes interleukin-6 with the hyphen. Which one is good? I tried checking online references, but both styles are used, with the hyphenated one MAYBE being more common... CielProfond (talk) 21:09, 9 March 2012 (UTC)[reply]

agree that the hyphenated form is more common and is the main form in literature database medical subject headings (e.g. PubMed/NLM). This article name - Interleukin 6 [without the hyphen] - needs amending. Am learning how this should be done now! Mangofast (talk) 09:40, 24 February 2016 (UTC)[reply]

Epigenetic modification

Added more details about how IL-6 activates epigenetic changes in order to give a greater understanding of how IL-6 is related to neurological disorders — Preceding unsigned comment added by Cbavley (talk • contribs) 19:45, 2 May 2013 (UTC)[reply]

Considering the universal role of IL-6 in neurodegeneration and neuroinflammation, might it be appropriate to discuss the broader implications before jumping into specific diseases? Perhaps under a new sub-heading? Food for thought. Serotonick (talk) 05:36, 17 May 2013 (UTC)[reply]

Role as myokine (moved from article)

This section needs correction as it is severely overpresented and is needlessly referencing many works of one and the same author. IL-6 as myokine is overpresented to the point of making the whole article imbalanced. People without knowledge in the field would think that the main role of the IL-6 is being an "anti-inflammatory myokine", while its research and importance in inflammatory and infectious diseases and therapy is manyfold greater. Furthermore, this section is evident and unneeded reference spam - all of the referenced sources in this section are (co)written by Pedersen BK. --Tkelava (talk) 08:00, 9 January 2019 (UTC)

Anti inflammatory vs Pro inflammatory?

The article contradicts itself by stating IL 6 is anti inflammatory and then later it is pro inflammatory. This needs addressing 81.78.174.220 (talk) 18:43, 25 April 2023 (UTC)[reply]

[1] Elias A. Said et al. 2009, PD-1 Induced IL10 Production by Monocytes Impairs T-cell Activation in a Reversible Fashion. Nature Medicine. 2010; 452-9.

[1]