Talk:Human iron metabolism

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Untitled

Seeking illustration[s] for the IRE-BP portion of this article Joewright 16:33, 16 November 2006 (UTC)[reply]

I hope I'll draw one when I'll have a time (not before November) ilia 14:16, 15 October 2007 (UTC)[reply]

What are the paths for excretion?

There is a lot in the article about the input of iron to the body but hardly anything about the output. Iron is an element and does not disappear into thin air! Since it does not accumulate indefinitely in the body either, there must be some excretion path.

The article mentions menstrual blood, pregnancy and lactation; but what about the adult male, or female after menopause?

The article says:"humans have no physiologic regulatory mechanism for excreting iron". I suppose that just means that there is some excretion mechanism, but that it is not regulated. What is that mechanism?

David Olivier (talk) 16:38, 14 February 2008 (UTC)[reply]

Some iron is excreted through fingernail and hair growth. 65.1.143.92 (talk) 02:32, 24 April 2008 (UTC)[reply]

How much? I'd be surprised if it was a significant path of excretion. David Olivier (talk) 16:17, 13 July 2008 (UTC)[reply]

As you imagined there's no regulated mechanism of iron excretion. Anyway, iron can be lost in many ways. As you said hair loss and fingernails account for some iron loss, but from a quantitative point of view epithelial exfoliation (skin and gut) and blood losses are far more relevant. It's really hard - if not impossible - to say how much iron is lost through hair loss and fingernail. Tleonardi (talk) 18:24, 8 May 2010 (UTC)[reply]

In the old days, parasites were much more common. They accounted for significant iron loss, which is partially why the body is so efficient at holding onto its iron. — Preceding unsigned comment added by 216.228.112.21 (talk) 19:28, 21 September 2011 (UTC)[reply]

Historical review

http://bloodjournal.hematologylibrary.org/cgi/content/full/112/2/219 - Nancy Andrews giving a historical overview of the recent developments. JFW | T@lk 21:04, 7 July 2008 (UTC)[reply]

Scheme

You can use: File:Schematic overview of the main elements considered to participate in mammalian iron metabolism.jpg --CopperKettle 03:57, 16 August 2009 (UTC)[reply]

THANK YOU!

Thank you very much to all the medical Wikipedians who contributed to this article. It is extremely helpful, well-written and informative, and I personally appreciate this much-needed information being made available on my favorite site. Keep up the great work. jengod (talk) 17:02, 22 February 2010 (UTC)[reply]

Referencing

The references list at the end of the article is in poor quality format, PMID/DOI numbers missing and without linkouts. If someone has time/pubmed access it could be fixed quickly. FruitywS (talk) 14:54, 11 March 2012 (UTC)[reply]

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Fixed Boghog (talk) 15:57, 11 March 2012 (UTC)[reply]

Iron regulation by hepcidin

JCI review JFW | T@lk 19:57, 3 June 2013 (UTC)[reply]

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Review

doi:10.1111/bjh.15403 JFW | T@lk 06:36, 15 August 2018 (UTC)[reply]

Requested move 23 May 2022

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.

The result of the move request was: Not Moved (non-admin closure) >>> Extorc.talk 12:28, 30 May 2022 (UTC)[reply]

(non-admin closure)

Human iron metabolism → Iron in biology – Please place your rationale for the proposed move here. Immanuelle 💗 (please tag me) 00:35, 23 May 2022 (UTC) I propose moving this article to Iron in biology and making it more general than humans. Focusing more on Iron-Sulfur proteins among other things Immanuelle 💗 (please tag me) 00:34, 23 May 2022 (UTC)[reply]

Oppose. Instead, I think it would be great if someone started a broad concept article at Iron in biology that could contain a summary of human content and link to it, in addition to iron-sulfur proteins, iron in microbiology, etc.. The current article is too human-centric to try to make it a broader article, what is needed is a separate article. Mdewman6 (talk) 18:17, 25 May 2022 (UTC)[reply]
Oppose This article is about iron homeostasis in humans, a very different topic which has almost nothing in common with iron homeostasis in prokaryotes. Neodop (talk) 19:37, 28 May 2022 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.