Talk:Hemosiderin

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Could you upload the image to the Commons?

.. So I can use it in the Russian version of the article.--CopperKettle 11:54, 22 August 2006 (UTC)[reply]

Done! InvictaHOG 15:02, 22 August 2006 (UTC)[reply]

Composition of hemosiderin

It was my understanding that hemosiderin is composed of pieces of degraded ferritin which have aggregated into granules, plus the iron to which the ferritin was bound. This article does not mention ferritin as a component of hemosiderin. Thewookie55 02:19, 3 October 2007 (UTC)[reply]

Hemosiderin as storage iron

These informations are quoted from Kumar & Clark's Clinical Medicine, and Guyton & Hall Textbook of Medical Physiology.

Hemosiderin is an insoluble iron-protein complex found in macrophages in the bone marrow, liver and spleen. Unlike ferritin, it is visible by light microscopy in tissue sections and bone marrow films after staining by Perls' reaction.
Ferritin is more easily mobilized than hemosiderin for hemoglobin formation.
About two-thirds of the total body iron is in the circulation as hemoglobin (2.5-3 g in a normal adult man). About 500-1500 mg is stored, two-thirds as ferritin and one-third as hemosiderin in normal individual.
Smaller quantities of iron in the storage pool are in an extremely insoluble form called hemosiderin. This is especially true when the total quantity of iron in the body is more than the apoferritin storage pool can accommodate. Hemosiderin collects in cells in the form of large clusters that can be observed microscopically as large particles. In contrast, ferritin particles are so small and dispersed that they usually can be seen in the cell cytoplasm only with the electron microscope.
The iron storage pool, consisting of hemosiderin and ferritin-bound iron in the liver, spleen, bone marrow, and skeletal muscle, contains on average 15% to 20% of total body iron.<Robbins Basic Pathology, Kumar, Abbas, Aster. 9th edition./>
Hemosiderin is an insoluble product of ferritin degradation in lysosomes. Unlike ferritin, it does not circulate in serum. Appears as golden brown granules in hematoxylin-eosin stained tissue or as blue granules when stained with Prussian blue.<Rapid Review Pathology, Edward F. Goljan, 4th edition /> — Preceding unsigned comment added by Mhndsaad (talk • contribs) 10:17, 18 April 2016 (UTC)[reply]

Is Hemosiderin pathological?

This article relates to Hemosiderin as a pathological substance. I am not sure, but I think it may also exist normally in humans. See: http://www.vivo.colostate.edu/hbooks/molecules/ferritin.html Ehudzel (talk) 10:06, 5 July 2008 (UTC)[reply]

Additionally, Robbins Basic Pathology textbook states that in cases of intravascular hemolysis (as in a hemolytic anemia secondary to something like Glucose-6-Phosphate Dehydrogenase deficiency) hemosiderinemia (too much hemosiderin in the blood) may ensue. This acts as a marker of pathological damage, but I'm not sure that it is in fact a pathological substance. In the case of hemoglobinemia, we see that rapid tubulitis in the kidneys may lead to acute renal failure. In this case hemoglobin is acting as an actual pathological agent. I will look into it further to see if any primary literature supports the idea and try to give a source with the data to make a post shortly about it. Good question. I'm a second year med student in South Carolina...not that being one lends me credibility, but I'm not some rogue internet nut either. —Preceding unsigned comment added by 208.36.227.203 (talk) 15:29, 20 November 2010 (UTC)[reply]

Hemoglobinemia causes renal tubular acidosis due to the Fe contained with in the Hemoglobin molecule itself. The Fe deposits in the renal tubules causing the so called "tubulitis" you are speaking about. Hemosiderin is a complex of ferritin which binds Fe 3+ or ferric iron which is responsible for the renal tubular acidosis. —Preceding unsigned comment added by 99.160.250.48 (talk) 00:44, 3 December 2010 (UTC)[reply]

In response to hemorhage?

"in an info regarding hemosiderin, the info is that it accumulates in body in response of hemorhage. it is not true. it is increased in body in response to hemolysis. pls see the reference hematology books for confirmation. [...] the interpretation of the reference [1] is not correct bc after bleeding into tissue the red cells are broken down (hemolysed by macrophages as stated in earlier e mail) and heme and other things are liberated (as in hemolysis). then it is converted to hemosiderin. while in bleeding there is blood loss (iron as well). depletion of body iron created a deficiency state rather than an excess state (iron overload which contributes to hemosiderin accumulation in the body)." -- Mubasher R Khan, via ticket:2010083010004245. -- Jeandré, 2010-09-01t11:35z