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Wiki Education Foundation-supported course assignment

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Wpongster8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:37, 16 January 2022 (UTC)[reply]

The Progranulin Project

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Hi!


The goal of this project is to present an updated review on progranulin's role in both healthy and diseased individuals. I plan on reorganizing the entire page to fit this goal while maintaining the information that is already present on this page. The primary focus of the page will be on circulating theories on progranulin function. I am wondering what the community thinks about the proposed outline. All feedback (especially constructive criticism) is welcome!


Introduction


Structure

1) Genetic

2) Protein


Expression

1) Expression Levels Across Cell Types

2) Post-Translational Modifications

3) Epigenetic


The Difference Between Progranulin and Granulin


Function

1) Trophic Factor in Development

  a. Neurite Outgrowth

2) Synaptic Pruning

3) Wound Healing

4) Inflammatory Response

  a. Peripheral Cells
  b. Central Nervous System

5) Cell Proliferation

6) Signaling Pathways

  a. SORT1

7) Maintaining Protein Homeostasis

  a. Lysosome


Disease

1) FTLD

2) Cancer

3) Metabolic Disease

4) Neuronal Ceroid Lipofuscinosis


Current Areas of Research


Current Models

1) Mice

2) In Vitro — Preceding unsigned comment added by Wpongster8 (talkcontribs) 07:28, 10 May 2018 (UTC)[reply]