Talk:Goodpasture syndrome

Medicine: Nephrology / Pathology / Pulmonology Mid‑importance

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Treatment

Is there any citation for this statement, which seems counterintuitive: "and these infections may result in a worsening of the primary disease". It's not clear that infections will actually exacerbate circulating anti-GBM antibodies or autoimmune response to the GBM. I have removed that clause pending some kind of citation for this. Derek Balsam 00:18, 14 May 2007 (UTC)[reply]

type 2 cytotoxic vs noncytotoxic

It is type 2 noncytotoxic, correct? Tkjazzer 20:56, 11 November 2007 (UTC)[reply]

Early treatment

PMID 11388816 - 2001 early treatment seems to be good. JFW | T@lk 19:23, 16 June 2008 (UTC)[reply]

Anti-GBM disease

Anti-GBM disease is not equal to Goodpasture's syndrome. Here is a quote from Harrison's: "Patients who develop autoantibodies directed against glomerular basement antigens frequently develop a glomerulonephritis termed antiglomerular basement membrane (anti-GBM) disease. When they present with lung hemorrhage and glomerulonephritis, they have a pulmonary-renal syndrome called Goodpasture's syndrome." Anti-GBM disease can be part of Goodpasture's syndrome but can also present on its own. This distinction should be made more clear, especially as many patients with Anti-GBM disease might get wrongfully worried about their lungs (thinking they have Goodpasture's). --Bastilleday uky (talk) 03:04, 30 September 2009 (UTC)[reply]

Other sources use the terms interchangeably, and the antigen is exactly the same in all three locations (kidney, lungs, and blood-brain barrier). WhatamIdoing (talk) 03:51, 30 September 2009 (UTC)[reply]

I agree with Bastilleday uky. The antigen might be the same, but in Goodpasture's syndrome these antigens injure the lungs too, while in Goodpasture's disease they damage only the kidneys. From Robbins: "Anti-Glomerular Basement Membrane Antibody (Type I) Crescentic Glomerulonephritis Anti-GBM antibody crescentic glomerulonephritis, or type I CrGN, is characterized by linear deposits of IgG and, in many cases, C3 on the GBM, as described above. In some of these individuals the anti-GBM antibodies also bind to pulmonary alveolar capillary basement membranes to produce the clinical picture of pulmonary hemorrhages associated with renal failure. These persons are said to have Goodpasture syndrome, to distinguish their condition from so-called idiopathic cases in which renal involvement occurs in the absence of pulmonary disease. Anti-GBM antibodies are present in the serum and are helpful in diagnosis. It is important to recognize type I CrGN because these individuals benefit from plasmapheresis, which removes pathogenic antibodies from the circulation."--B@xter⁹ 13:43, 2 June 2010 (UTC)[reply]