Talk:Glutamate decarboxylase

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Untitled

I added content about the involvement of GAD67 in schizophrenia. Specifically, I added an explanation that may account for why GAD67 levels are lower in schizophrenics and how this molecular alteration may contribute to the working memory impairments often observed in patients. — Preceding unsigned comment added by Jgalvin2015 (talk • contribs) 15:48, 7 December 2014 (UTC)[reply]

The following text on L-Glutamic acid decarboxylase was replaced with a redirect to this article:

L-Glutamic acid decarboxylase (GAD) (EC 4.1.1.15) is an enzyme necessary for the synthesis of the inhibitory neurotransmitter GABA in GABAergic nerve endings. In the presence of pyridoxal phosphate as cofactor, the enzyme decarboxylates glutamate to yield GABA and CO₂. GAD exists in two isoforms encoded by two different genes. These isoforms are GAD₆₅ and GAD₆₇ with molecular weights of 65 and 67 kDa, respectively. GAD67 is only present in GABAergic neurons and so can be used as a marker.

In experimental animals, administration of drugs to inhibit GAD invariably leads to epileptic seizures. People with diabetes mellitus type 1 often have autoantibodies against GAD65, leading to speculation about the role these antibodies play in the development of diabetes mellitus.^[1]

References

^ Kim, Seon-Kyeong (2004). "Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (39): 14204–14209. doi:10.1073/pnas.0405500101. PMID 15381770. Retrieved 2006-07-06. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)

GAD transfer gene therapy for Parkinson's

Interesting theme, could be investigated and some info added in the article. (PMID 11529246, PMID 17586305; also some media articles). CopperKettle 12:14, 5 July 2007 (UTC)[reply]

Perhaps someone could add something about Stiff Person Syndrome and high anti-GAD antibodies. — Preceding unsigned comment added by 98.127.162.136 (talk) 04:31, 22 September 2011 (UTC)[reply]

GAD Regulation

Added information about the regulation and synthesis of GAD65 and GAD67 to help show the differences between these two proteins and how differences in their regulation can highlight differences in their function. — Preceding unsigned comment added by Cbavley (talk • contribs) 19:46, 2 May 2013 (UTC)[reply]

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[diabetogenic-1] Kim, Seon-Kyeong (2004). "Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (39): 14204–14209. doi:10.1073/pnas.0405500101. PMID 15381770. Retrieved 2006-07-06. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)

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