Talk:Glucocorticoid remediable aldosteronism

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This article is a good contribution to Wikipedia.

I'm not familiar with this topic, and I have a few minor suggestions which may make the article easier to understand for people like me.

In the first sentence, perhaps "no longer transient" could be replaced with "not merely transient" or "not transient as in normal subjects", if those are accurate descriptions.

It would be helpful to state, and/or provide a wikilink to, a straightforward description of how these processes occur in normal subjects, perhaps in a few sentences which could be added at the beginning of the pathophysiology section. What, if anything, happens in normal subjects in response to the presence of ACTH?

Please clarify: Is it the production of aldosterone synthase which is sensitive to ACTH, or is the aldosterone synthase itself sensitive to ACTH? In other words, what happens when ACTH is present: is aldosterone synthase produced, or does aldosterone synthase which is already present become active and produce aldosterone? I think you may mean the former, but the article seems to be stating the latter: "an ACTH-sensitive aldosterone synthase".

What does "5'" mean in this context? The wikilink doesn't seem to provide enough information. Is the "5' regulatory region" a series of nucleotides, or one side of one nucleotide, or something else? Is there another wikilink that would be more helpful in explaining "5' regulatory region", or could the Directionality (molecular biology) page which is wikilinked to here be modified to be more helpful about this? From the description on this page, I don't get a clear picture of how the normal genes are arranged and how the pathological genes are arranged; for example, is an amount of genetic material approximately equal to the size of one gene missing in the pathological case?

Is this all about humans, or is it implied that it might occur in other species? I wonder if this should be mentioned; or maybe it's not necessary to mention it if the sources gloss over this point and if we have no information about whether it may or may not occur in other species.

I hope these comments are helpful. ☺Coppertwig(talk) 20:03, 3 January 2009 (UTC)[reply]