Talk:Germline mutation

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Genetics task force (assessed as High-importance).
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).

Evolutionary biology High‑importance

	Evolutionary biology portal This article is part of WikiProject Evolutionary biology, an attempt at building a useful set of articles on evolutionary biology and its associated subfields such as population genetics, quantitative genetics, molecular evolution, phylogenetics, and evolutionary developmental biology. It is distinct from the WikiProject Tree of Life in that it attempts to cover patterns, process and theory rather than systematics and taxonomy. If you would like to participate, there are some suggestions on this page (see also Wikipedia:Contributing FAQ for more information) or visit WikiProject Evolutionary biologyEvolutionary biologyWikipedia:WikiProject Evolutionary biologyTemplate:WikiProject Evolutionary biologyEvolutionary biology articles
High	This article has been rated as High-importance on the project's importance scale.

Medicine: Genetics Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.
	This article is supported by the Medical genetics task force.

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Cjp0001. Peer reviewers: Mrp0007, Jboyle0.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 21:46, 17 January 2022 (UTC)[reply]

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Kristinr.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:20, 16 January 2022 (UTC)[reply]

External links modified

Hello fellow Wikipedians,

I have just modified 2 external links on Germline mutation. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 03:24, 15 October 2017 (UTC)[reply]

Article Evaluation

The lead of this article provides an insightful understanding for the definition of a germline mutation, while also providing a brief description for each of the article's major components. Although vague in detail, the mention of it's occurrence, causes, clinical implications, and current therapies were present. This allows for viewers, like myself, to be informed of the exact content that is expected to follow. On a side note, this article can still be improved in some areas. There were a few sentences that could have been reworded for a better understanding. For example, the sentence, "This damage is rarely repaired imperfectly, but due to the high rate of germ cell division, can occur frequently." I had to go over this sentence numerous times to understand what was trying to be conveyed. It would have been easier to understand if it was written as, "Because of the high germ cell division rate, the damage occurs frequently, however, this damage is usually perfectly repaired." I would recommend adding more information about how common germline mutations occur and provide statistics to give viewers an idea of how many individuals are affected by such a mutation.

Another improvement that could be made involves creating two different sub-headings underneath the "Clinical Implications" heading. One for the role it plays in genetic diseases and another for the role it plays in different types of cancer. Not only would this help distinguish which category each of the conditions fall under, but it also allows for better organization of the article. In general, more information about how a germline mutation leads to different types of cancer would be a good improvement to this article. This section of the article did not contain enough detailed information and could be expanded upon. Nonetheless, this article possesses content that is up-to-date. While scrolling through the references, I noticed that a good portion of the cited sources were retrieved/published a few years ago. I found myself looking through these recent references that were cited, the latest one retrieved from 2018. Kaira Hosnedl (talk) 22:52, 6 September 2020 (UTC)[reply]