Talk:Genetics of obesity

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July 19, 2013 article

Those with a more comprehensive understanding of the topic than I have, may want to add content based on this article: "New Genes IDd in Obesity: How Much of Weight is Genetic?". It seems to express a step forward in the study of genes and obesity. RCraig09 (talk) 22:44, 19 July 2013 (UTC)[reply]

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Hello there!

While i was reading this article I feel like it was missing some of the information like the specific type of genes that causes obesity and so I added some pararaphs on the monogenic, polygenic and syndromic obesity genes and also talked about their treatments. Anwaramna15 (talk) 20:48, 2 May 2017 (UTC)[reply]

Genes

Have moved here.

MC4R

MC4r is one of the polygenic gene that mostly likely to be mutated and is found in the hypothalamus part of the brain^[1]. MC4r gene code for the protein Melanocortin receptor 4. The function of this gene is to let our brain know when we are full through the from of energy we get from food. This process happens when we consumes food which sends energy to the gene MC4r and this gene signals Melanocortin receptor 4 to signal our brain to suppressed the hunger signal. The hunger signal is accomplished by orexigenic neuron which trigger our appetite and the word “orexigenic” is derrived from the word appetite.^[2] On the other hand, when we are hungry the MC4r gene attaches to Melanocortin receptor 4 again and now it signals to be full. and when we however, the mutated Mc4r lacks enough Melanocortin recptor 4. You might be thinking that if MC4r is just binding to melanocotrin receptor 4 to trigger both hunger and full signal, so what is the different. Well “health watcher” include that there is a difference in the types of hormone and protein. Weight watcher also mentioned that the “being full” is signaled by high energy that sent leptin or insulin to release the α MSH hormone which attaches to Melanocortin receptor 4 and as a result it decreases the hormone level that make us feel full^[3]. Unlikeliness to full signal, hunger signals are triggered by low energy which sent ghrelin to trigger Agrp protein that attaches to Melanocortin receptor 4 and as a result the hormone are increased which led in the signal of hunger.^[3]

Some of the issues, the free dictionary is not a suitable source, neither is GBHealthWatch. FOr the book you provide you give no page number. Doc James (talk · contribs · email) 22:00, 2 May 2017 (UTC)[reply]

The obese gene

A number of scientific articles refer to the obese gene. What is that gene? ◅ Sebastian 03:05, 4 September 2020 (UTC) (I stopped watching this page. If you would like to continue the talk, please do so here and ping me.)[reply]

References

^ B., Reece, Jane; 1946-2004., Campbell, Neil A.,. Biology : a global approach. ISBN 9780321775658. OCLC 903099858. {{cite book}}: |last2= has numeric name (help)CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
^ "Appetite-Enhancing Drugs". TheFreeDictionary.com. Retrieved 2017-04-23.
^ ^a ^b "Obesity and the MC4R Gene". www.gbhealthwatch.com. Retrieved 2017-04-23.

[1] B., Reece, Jane; 1946-2004., Campbell, Neil A.,. Biology : a global approach. ISBN 9780321775658. OCLC 903099858. {{cite book}}: |last2= has numeric name (help)CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)

[2] "Appetite-Enhancing Drugs". TheFreeDictionary.com. Retrieved 2017-04-23.

[:1-3] "Obesity and the MC4R Gene". www.gbhealthwatch.com. Retrieved 2017-04-23.

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