Talk:GI cocktail

Pharmacology High‑importance

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Medicine: Gastroenterology High‑importance

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Comment

The GI Cocktail is no more effective than plain liquid antacid: a randomized, double blind clinical trial.Berman DA, Porter RS, Graber M. Department of Emergency Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.

The "GI Cocktail" is a mixture of medications often given in the Emergency Department (ED) for dyspepsia symptoms. Several combinations are used, but the most effective has not yet been determined. This study compared three combinations commonly given for dyspepsia. The study was a prospective, randomized, double-blinded trial comparing antacid (group 1); antacid + Donnatal (group 2); antacid + Donnatal + viscous lidocaine (group 3) for acute treatment of dyspepsia in the ED. Patients were randomly assigned to receive one of the three medication combinations. Patients rated their discomfort on a Visual Analog Scale (VAS) immediately before receiving the medication and 30 min later. Change in VAS was the primary study endpoint. A 13-mm difference in VAS was considered clinically significant. VAS change in the three groups was compared using multivariable regression, controlling for pretreatment VAS, study drug, previous antacid use, and gastrointestinal (GI) history. One hundred twenty patients were enrolled between July and December 2000. One hundred thirteen subjects (113) completed the protocol: Group 1 (N = 38); Group 2 (N = 37); Group 3 (N = 38). There was no statistically significant difference between the groups in terms of age, gender, GI history, previous antacid use, or initial degree of pain. Group 1 had a 25 +/- 27 mm mean (+/- SD), decrease in pain; Group 2, 23 +/- 22 mm decrease; and Group 3, 24 +/- 26 mm decrease. There was no statistically significant difference in pain relief between the three groups on univariate analysis or multivariable regression. In conclusion, the addition of Donnatal or Donnatal + lidocaine to an antacid did not relieve dyspepsia better than plain antacid. The "GI Cocktail" concoction may not be necessary.

Wiki Education assignment: 2021-22 TCOM WikiMed Directed Studies

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 February 2022 and 25 March 2022. Further details are available on the course page. Student editor(s): Amahaja1 (article contribs). Peer reviewers: UnknownSignificanceDO.

Work Plan

My plan is to improve the article is as follows:

Lead Section: Rework the lead section to define the topic and provide a concise overview of the GI cocktail. This includes adding to the introductory sentence and including a brief description of the article’s major sections (described under “Content”).

Content: I plan to add up-to-date information regarding conditions for which the GI cocktail has been used, side effects of the GI cocktail, and addressing studies that claim the GI cocktail is no more effective than an antacid alone.

Tone and Balance: Maintain a neutral point of view while reworking the article and providing additional information regarding the GI cocktail.

Sources and References: Expand upon sources and references already provided in the article by providing ones that are more current and up-to-date. Additionally, using resources from peer-reviewed articles, medical journals, etc.

Organization and Writing Quality: Maintain a clear and professional tone throughout while keeping the article concise, clear, and easy to read.

Images and Media: If applicable, provide images and media that enhance understanding of the GI cocktail Amahaja1 (talk) 01:04, 7 March 2022 (UTC)[reply]