Talk:Fibrin

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Molecular Biology: MCB

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History

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2006.02056.x seems to be about the history of fibrinogen. JFW | T@lk 19:52, 26 July 2006 (UTC)[reply]

Graphics

can we get a real picture of the makeup of fibrin? I don't really understand how the ASCII one represents fibrinogen and I can't find a real one.HolyMongoose 17:44, 28 September 2006 (UTC)[reply]

Clean up tag?

Huh? The section looks accurate to me. Ok, so I work with the stuff, but anyone with college Chemistry should be able to follow it, and the writing doesn't seem bad. People who put "clean up" tags on really should explain to the authors what they think is wrong. Utgard Loki 13:32, 29 January 2007 (UTC)[reply]

Well, there aren't any references cited for anything. It would be nice to see some references to the claimed normal levels and such. --gwax UN (say hi) 22:41, 29 October 2007 (UTC)[reply]

There are a couple things I would do. For example zymogen is just kind of thrown out there as some sort of every day word that people should just be expected to know. The concept would be easy enough to add. The section on low fibrinogen being characteristic of liver damage should be moved to the diagnostic uses section, I would also like to see some sort of mention of D-dimer in there somewhere, and perhaps a link to plasminogen, as fibrinogen and plasminogen are intricately linked. In the physiology section there's a reference to megakaryocyte wihtout a link. Actually the whole physiology section is relatively link free. I can understand most of what's trying to be said but there's still significant amounts of relatively unexplaind things that untrained individuals will just say "WTF" to, and ultimately thats what Wikipedia is for, the untrained individual. —Preceding unsigned comment added by 170.173.0.16 (talk) 18:57, 27 February 2009 (UTC)[reply]

How about this for an example of something that should be revised: "In lectins, such as mammalian ficolins and invertebrate tachylectin 5A, the fibrinogen C-terminal domain binds carbohydrates." This is clearly beyond anyone but a specialist in this area, and specialists in this area do not need an encyclopedia to explain their field to them. Encyclopedias should be written for literate lay audiences, and should be written by someone who can understand that. Franklinjefferson (talk) 11:43, 20 May 2009 (UTC)[reply]

Can you simplify it please?

I'm a biology student and needed to find out about Fibrinogen and fibrin, my book told me that they were just soluble and insoluble blood proteins respectively. It would help Wikipedia a lot if they had a section which simplifies over-complicated technological language found in articles such as this and then dumbed them down for the layman to understand, it would be greatly appreciated by many (we're not all scholars y'know)

How about examples of fibrinogen levels?

range levels reference between 207-436 and alert value >=350. The goal being <350. Give example of severity? If risk level for individual is 567; what level of risk is this and dangers involved? —Preceding unsigned comment added by 167.80.246.204 (talk) 17:23, 5 February 2010 (UTC)[reply]

Role of fibrin in capillary permeability

This should be of concern, no? Fibrin is the "binding agent" in capillary walls.--84.163.113.27 (talk) 19:45, 17 October 2008 (UTC)[reply]

Image

The section headed Image says "the image above..." I assume this means the image above the infobox since that is the only image on the page (though that isn't where I first looked). Also, the text is rather difficult to follow. How much of this is needed and can we make it clearer and simpler? RJFJR (talk) 17:29, 25 November 2008 (UTC)[reply]

I actually removed the whole section but someone restored it. I copied the image next to it (and change 'above' to 'at right' so is easier to see image while reading description, but I still don't see the section as very useful. RJFJR (talk) 19:31, 1 January 2009 (UTC)[reply]

I would have to agree, any time I see someone post a ribbion diagram of a complex protein and expect someone to understand it That person is either a savant, or a post doc. A better image would be one that shows the D-E-D configuration in a more conceptual view, and less convoluted. I dont really know copyright policy or I would be willing to post up a few images I have set aside for lecture.

Redirect from fibrinogen

If fibrin is made from fibrinogen, why does fibrinogen redirect here, instead of having its own article? --JorisvS (talk) 11:26, 15 January 2010 (UTC)[reply]

Indeed, I'll try to split it. --Lysy^talk 16:13, 16 June 2010 (UTC)[reply]

I am not at all sure that this split is a good idea. The first problem is that the split separates the fibrinogen gene from the fibrin protein and the sequence of the later is determined by the former. Furthermore any diseases as a result of mutations in the fibrinogen gene are a consequence of altered fibrin function. The second problem is that there is currently only information about how fibrinogen is converted into fibrin in the fibrinogen article. While this information could also be added to the fibrin article, but this is an unnecessary duplication of information that will be more difficult to maintain if it is split between two articles. There are a large number of Gene Wiki articles about genes, the proteins encoded by these genes, and the various splice variants and posttranslational modifications. Rarely do we have separate articles about parent proteins and their cleavage products. By analogy, while there are separate article about chickens and eggs, there are no articles specifically about chicken eggs. Hence I think it would be better to re-merge the two articles into one. Boghog (talk) 17:44, 16 June 2010 (UTC)[reply]

how about more stuff

how about a mention of defibrination syndrome and why it's a bad thing and a pointer to the article? how about a mention of defibrination when it is done deliberately while pouring blood into a container of glass beads or chips, why it's done, and so on? 108.56.212.179 (talk) 20:19, 2 September 2013 (UTC)[reply]

Rewrite of first two paragraphs

I rewrote the first two paragraphs for clarity. If you don't like it, change it.

If anyone knows how to add arrows to pictures, point one at the fibrin.

IiKkEe (talk) 01:26, 18 April 2014 (UTC)[reply]

fibrin images

Google "fibrin images" for lots of beautiful pictures.

IiKkEe (talk) 01:31, 18 April 2014 (UTC)[reply]

Serious error in image

Image:Genesis_of_Fibrin_out_of_Fibrinogen.svg

The image in this article has a very serious error: Factor VII is listed when it should be Factor XIII. The error is especially unfortunate given that the author's source shows the correct clotting factor. I see that someone has previously added a caption mentioning the error. Nevertheless, since the image is still up, has not been edited, and is the cause of widespread confusion (google "fibrin" or "clot formation," etc, and you'll find the same error re-stated ad nauseum due to this single unfortunate image), I strongly recommend deleting the image altogether. If there are no objections, I will do so.Global Cerebral Ischemia (talk) 15:05, 19 March 2019 (UTC)[reply]

I've now uploaded a new, corrected version of this image here, however the preview still shows the original; is that normal? Global Cerebral Ischemia (talk) 16:26, 19 March 2019 (UTC)[reply]

If there are no objections, I will restore the image in the article with the hope that it displays the new corrected version.Global Cerebral Ischemia (talk) 16:27, 19 March 2019 (UTC)[reply]

Is this article really necessary?

I think it would be good idea to merge this article to fibrinogen or vice versa. Currently it is redundant. There are no separate articles for prothrombin/thrombin or for all of the angiotensins for example. 5-HT2AR (talk) 23:07, 12 November 2019 (UTC)[reply]

Clotting

I wanna talk about fibrin 41.223.116.242 (talk) 19:21, 28 September 2022 (UTC)[reply]

mRNA, fibrin, reports

There is an overproduction of fibrin that overflows eventually gathering and coagulating in the lower arteries according to reports from embalmers. The inference that it is mRNA related comes from recent UK study showing significant statistical death rates between vaxxed and totally unvaccinated. 101.178.42.12 (talk) 02:58, 27 September 2023 (UTC)[reply]